Activation of β-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis. | Cooperative Human Tissue Network Western Division

Soutto M, Peng D, Katsha A, Chen Z, Piazuelo MB, Washington MK, Belkhiri A, Correa P, El-Rifai W. Activation of β-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis. Gut. 2014 Aug 8. PMID: 25107557 [PubMed]

Abstract

In this study, we investigated the role of Trefoil factor 1 (TFF1) in regulating cell proliferation and tumour development through β-catenin signalling using in vivo and in vitro models of gastric tumorigenesis.