The Aronoff Lab studies host-microbial interactions with an emphasis on bacterial infections and innate immunity. Our microbiology & immunology research centers primarily on two major organ systems:

  • FEMALE REPRODUCTIVE TRACT 
  • GASTROINTESTINAL TRACT

 

Macrophages, neutrophils, and epithelial cells are the innate immune cells we study most commonly. For macrophages (& neutrophils) our focus is on the regulation of 3 primary functions:

  • Receptor-mediated recognition & phagocytosis of bacteria. 
  • Mechanisms of intracellular killing of bacteria.
  • The production of inflammatory mediators (e.g., cytokines, chemokines, & lipids). 

 

Our microbiological studies focus on these Gram positive bacteria:

  1. The postpartum sepsis-causing bacterium Streptococcus pyogenes (Group A Streptococcus) and Streptococcus agalactiae (Group B Streptococcus).
  2. The anaerobic, spore-forming bacterium Clostridium difficile, the most common cause of antibiotic-associated diarrhea. 
  3. The spore-forming, obligate anaerobic bacterium Clostridium septicum, which can cause myonecrosis (gas gangrene).
  4. The rare, toxic shock-causing bacterium Clostridium sordellii (also an anaerobe), which can also cause peritonitis. 

 

Clinical Trials going on in Aronoff Lab:

  1. Development of a Group B Streptococcus Urinary Antigen Detection Assay (Pfizer).
  2. PROCLAIM is a clinical trial for adults aged 50 years old and older who been diagnosed with a C. difficile infection.

March for Science 2017Kirk MforS

March for Science, 2017, Nashville TN