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Ebong IA, Wilson MD, Appiah D, Michos ED, Racette SB, Villablanca A, Breathett K, Lutsey PL, Wellons M, Watson KE, Chang P, Bertoni AG. Relationship Between Age at Menopause, Obesity, and Incident Heart Failure: The Atherosclerosis Risk in Communities Study. Journal of the American Heart Association. 2022 Dec 19;11(11). e024461.
Abstract
Background The mechanisms linking menopausal age and heart failure (HF) incidence are controversial. We investigated for heterogeneity by obesity on the relationship between menopausal age and HF incidence. Methods and Results Using postmenopausal women who attended the Atherosclerosis Risk in Communities Study Visit 4, we estimated hazard ratios of incident HF associated with menopausal age using Cox proportional hazards models, testing for effect modification by obesity and adjusting for HF risk factors. Women were categorized by menopausal age: