Menon R, Aronoff D, Rogers L, Osteen K, Ding T, Gnecco J, Richardson L. Fetal Membrane Organ-On-Chip: An Innovative Approach to Study Cellular Interactions. Reproductive sciences (Thousand Oaks, Calif.). 2019 Feb 21. 1933719119828084 p. PMID: 30791822 [PubMed]
Fetal membranes, a vital component that helps maintain pregnancy and contribute to parturition signaling, are often studied in segments due to its structural complexity. Transwells are traditionally used to study cell interactions; however, their usefulness is limited. To overcome these difficulties, a fetal membrane-organ-on-chip (FM-OO-C) was created to study interactive properties of amnion epithelial cells (AECs) and decidual cells compared to transwell systems.