Chemokine Network and Overall Survival in Wild-Type and Mutant Ovarian Cancer.


Ovarian cancer (OC) has the highest mortality rate among gynecological malignancies. Because chemokine network is involved in OC progression, we evaluated associations between chemokine expression and survival in tumor suppressor protein p53 () wild-type (WT) and mutant (m) OC datasets. was highly mutated in OC compared to other cancer types. Among OC subtypes, CXCL14 was predominantly expressed in clear cell OC, and CCL15 and CCL20 in mucinous OC. WT endometrioid OC highly expressed CXCL14 compared to m, showing better progression-free survival but no difference in overall survival (OS). m serous OC highly expressed CCL8, CCL20, CXCL10 and CXCL11 compared to WT. CXCL12 and CCL21 were associated with poor OS in WT serous OC. CXCR2 was associated with poor OS in m serous OC, while CXCL9, CCL5, CXCR4, CXCL11, and CXCL13 were associated with better OS. Taken together, specific chemokine signatures may differentially influence OS in WT and m OC.