Clonal hematopoiesis and inherited genetic variation in sickle cell disease
Sickle cell disease (SCD) is marked by chronic hemolysis, systemic endothelial dysfunction, inflammation, and vascular occlusion, leading to severe pain, multi-organ damage, and a median lifespan of 48 years in high-income countries. Young adults with progressive heart, lung, or kidney damage are at heightened risk for premature death.