Welcome to the Laboratory for Organ Regeneration, Recovery, and Replacement (LOR3) at Vanderbilt University Medical Center.
The LOR3, directed by Matthew Bacchetta, MD, MBA, is focused on creating organ support systems that provide extended physiologic support for injured organs, bioengineering platforms for organ recovery and regeneration, and developing artificial cardiopulmonary assist systems. Our group is the first to develop a large pre-clinical cross-circulation platform for extracorporeal support of human lungs rejected for transplantation. We have also recently established a high-fidelity, titratable large pre-clinical model for pulmonary hypertension and right ventricular failure, a large pre-clinical platform that serves as a basis for developing the next-generation, durable mechanical support technology. Our work has been published in leading academic medical, scientific, and engineering journals, and also featured in major news outlets including The New York Times.
The LOR3 is an interdisciplinary team of clinicians, scientists, engineers, nurses, surgeons and the S.R. Light Research and Training Laboratory personnel. If you are interested in joining our effort, Contact Us.
Faculty and Staff of the LOR3 Lab
Projects
Transplant
- Cross circulation platform for lungs and livers
- Immune characterization of xenogeneic XC
- Dynamic storage of organs
- Preclinical and clinical evaluation of 10-degree storage in hearts and livers
- ECMO/Artificial Organs
- Durable mechanical cardiopulmonary support for pulmonary hypertension
- Smart ECMO system toward automation of cardiopulmonary support
- Improved vascular access for durable pulmonary assist system
Publications and Presentations
Pulmonary Hypertension/Right Heart Failure
Ukita, R. et al. Left Pulmonary Artery Ligation and Chronic Pulmonary Artery Banding Model for Inducing Right Ventricular - Pulmonary Hypertension in Large Pre-Clinical Model. ASAIO Journal E44–E48 (2021) doi:10.1097/MAT.0000000000001197.
Ukita, R. et al. A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Large Pre-Clinical Model. Journal of visualized experiments : JoVE (2021).
Ukita, R. et al. Progression Toward Decompensated Right Ventricular Failure in the Large Pulmonary Hypertension Model. ASAIO Journal 68, E29–E33 (2022).
Cross Circulation
Hozain, A. E. et al. Multiday maintenance of extracorporeal lungs using cross-circulation with conscious pre-clinical model. in Journal of Thoracic and Cardiovascular Surgery vol. 159 1640-1653.e18 (Mosby Inc., 2020).
Hozain, A. E. et al. Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs. Nature Medicine 26, 1102–1113 (2020).
Cross-Circulation for Extracorporeal Liver Support in a Large Pre-Clinical Model. ASAIO Journal (2021) doi:10.1097/MAT.0000000000001543.
Guenthart, B. A. et al. Regeneration of severely damaged lungs using an interventional cross-circulation platform. Nature Communications 10, (2019).
ECMO
Tipograf, Y. et al. Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation. Annals of Thoracic Surgery 107, 1456–1463 (2019).
Tipograf, Y. et al. A Dual-Lumen Bicaval Cannula for Venovenous Extracorporeal Membrane Oxygenation. Annals of Thoracic Surgery 109, 1047–1053 (2020).
Stokes, J. W. et al. Bleeding, Thromboembolism, and Clinical Outcomes in Venovenous Extracorporeal Membrane Oxygenation. Critical Care Explorations 2, e0267 (2020).
Stokes, J. W., Gannon, W. D. & Bacchetta, M. Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplant. Seminars in Respiratory and Critical Care Medicine 42, 380–391 (2021).
Gannon, W. D. et al. Association Between Availability of ECMO and Mortality in COVID-19 Patients Eligible for ECMO: A Natural Experiment. American Journal of Respiratory and Critical Care Medicine (2022) doi:10.1164/rccm.202110-2399LE.