***under construction***
Accelerating COVID-19 Therapeutic Interventions and Vaccines
VBDCC units: Design & Analysis, Data Management, Tool Development
VBDCC services include: study design, coordination with external sites, dashboards and reports
There is an extensive NIH section on the full ACTIV program, including its virtual biorepository.
ACTIV-4HT
Host Tissue protocol
VBDCC unit: Design & Analysis
VBDCC services include: study design, coordination with external sites, dashboards and reports
Biostatistics faculty and staff on this project have included:
- Matthew S. Shotwell, data coordinating center PI
- Josh DeClercq
- Jonathan Schildcrout
- Li Wang
Publications include:
Press:
- How biostatistics saves lives: the Vanderbilt experience (VUMC Reporter, October 17, 2023)
- VUMC-led trial shows two investigational drugs are ineffective for treating severe COVID-19 (VUMC Reporter, April 11, 2023)
- VUMC-led COVID-19 clinical trial platform goes international (VUMC Reporter, January 5, 2023)
ACTIV-6
COVID-19 Outpatient Randomized Trial to Evaluate Efficacy of Repurposed Medications
VBDCC units: Design & Analysis, Data Management, Tool Development
VBDCC services include: study design, coordination with external sites, dashboards and reports
Study website: activ6study.org
Biostatistics faculty and staff on this project include:
- Frank Harrell, VBDCC faculty lead
- Tom Stewart
- Sam Nwosu (DCC spotlight)
- Jubilee Tan (DCC spotlight)
- James Grindstaff
- Jess Lai
- Savannah Obregon (DCC spotlight)
Publications include:
- Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19: A Randomized Clinical Trial (JAMA, 2023)
- Higher-Dose Fluvoxamine and Time to Sustained Recovery in Outpatients With COVID-19: The ACTIV-6 Randomized Clinical Trial (JAMA, 2023)
Press:
- VUMC tests drugs for COVID outpatient treatment (VUMC Reporter, November 11, 2021)