The fields of infection biology, immunobiology and inflammation research is varied and ever-expanding. Researchers the world over are making discoveries that contribute greatly to our collective understanding of health and disease. VI4 is committed to providing our members, students, and community resources to aid in knowledge-building in these core VI4 research areas. Please check out our current curated recommended reading list below from scientists across the country!
Recommended Reading - April 10, 2022
- Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement. McCallum M, et al. in Science, January 25, 2022
- TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures. Chaurio R, et al. in Immunity, January 11, 2022
- KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19. Jing L, et al. in Science, March 8, 2022
- Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells. Fabio R, et al. in Science Immunology, March 4, 2022
- Rare and localized events stabilize microbial community composition and patterns of spatial self-organization in a fluctuating environment. Ciccarese D, et al. in The ISME Journal, January 25, 2022
Recommended Reading - January 9th, 2022
- Mapping the cellular origin and early evolution of leukemia in Down syndrome. Wagenblast E, et al. in Science, July 9, 2021
- Arthritis flares mediated by tissue-resident memory T cells in the joint. Chang M, et al. in Cell Reports, October 26, 2021
- An autoimmune stem-like CD8 T cell population drives type 1 diabetes. Gearty S, et al. in Nature, November 30, 2021
- Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer. Overacre-Delgoffe A, et al. in Immunity, December 2, 2021
- Heme-Dependent Siderophore Utilization Promotes Iron-Restricted Growth of the Staphylococcus aureus hemB Small-Colony Variant. Batko I, et al. in Journal of Bacteriology, November 19, 2021
Recommended Reading - December 19, 2021
- Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy. Bentires-Alj M et al. in Nature, June 2, 2021
- Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis. Jul`e A, et al. in JCI Insight, September 22, 2021
- The lungfish cocoon is a living tissue with antimicrobial functions. Heimroth R, et al. in Science Advances, November 17, 2021
- Human gut bacterial metabolism drives Th17 activation and colitis. Alexander M, et al. in Cell Host & Microbe, November 24, 2021
- γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans. Chu T, et al. in PLOS Pathogens, December 6, 2021
Recommended Reading - November 14, 2021
- Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers. Caushi J, et al. in Nature Biotechnology, July 21, 2021
- An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer. Voabil P, et al. in Nature, July 8, 2021
- Obesity results in adipose tissue T cell exhaustion. Porshe C, et al. in Science, April 22, 2021
- Diet-regulated production of PDGFcc by macrophages controls energy storage. Cox N, et al. in Nature Ecology & Evolution, July 2, 2021
- Maturation of the matrix and viral membrane of HIV-1. Qu K, et al. in Cell Host & Microbe, August 6, 2021
Recommended Reading - October 3, 2021
- MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells. Evavold B & Jenkins M et al. in Nature Biotechnology, May 23, 2021
- Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity. Mwakingwe-Omari A, Et al. in Nature, June 30, 2021
- SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell–mediated immunity. Yue T, et al. in Science, May 14, 2021
- Obligate cross-feeding expands the metabolic niche of bacteria. Oña L. Et al. in Nature Ecology & Evolution, July 15, 2021
- Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis. Koehler H, et al. in Cell Host & Microbe, August 11, 2021
Recommended Reading - September 27, 2021
- Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade. Fukumura K et al. in Cancer Immunology Research, April 10, 2021
- A microRNA expression and regulatory element activity atlas of the mouse immune system. Brown B et al. in Nature Immunology, June 7, 2021
- Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Beziat V, et al. in Cell, July 8, 2021
- Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas. Friedrich M, et al. in Nature Cancer, May 24, 2021
- Bifidobacteria-mediated immune system imprinting early in life. Hendrick B, et al. in Cell, July 22, 2021
Recommended Reading - August 15, 2021
- SorTn-seq: a high-throughput functional genomics approach to discovering regulators of bacterial gene expression. Fineran P et al. in Nature Protocols, August 4, 2021
- Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity. Duffy P et al. in Nature, June 30, 2021
- An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer . Thommen D et al. in Nature Medicine, July 8, 2021
- Introducing the Microbes and Social Equity Working Group: Considering the Microbial Components of Social, Environmental, and Health Justice . Morar n et al. in mSystems, July 27, 2021
- Matrix-trapped viruses can prevent invasion of bacterial biofilms by colonizing cells. Nadell C et al. in eLife, July 9, 2021
Recommended Reading - July 18th, 2021
- Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients. Baruch E, et al. in Science, February 5, 2021
- Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid. Heming M, et al. in Cell Immunity, January 12, 2021
- Human NLRP1 is a sensor for double-stranded RNA. Bauernfried S, et al. in Science, January 29, 2021
- Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression. DChen S, et al. in Nature Cell Biology, January 8, 2021
- A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression. Ostuni R et al. in Cell Immunity, June 14, 2021
Recommended Reading - June 6th, 2021
- The gut microbiota is associated with immune cell dynamics in humans. Schluter J, et al. in Nature, December 1, 2020
- Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation. Becattini S, et al. in Cell Host & Microbe, March 10, 2021
- Hyperglycemic Memory of Innate Immune Cells Promotes In Vitro Proinflammatory Responses of Human Monocytes and Murine Macrophages. Thiem K, et al. in The Journal of Immunology, January 11, 2021
- Bacterial-driven inflammation and mutant BRAF expression combine to promote murine colon tumorigenesis that is sensitive to immune checkpoint therapy. DeStefano Shields C, et al. in Cancer Discovery, February 25, 2021
- Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling. Hormaechea-Agulla D, et al. in Cell Stem Cell, March 19, 2021
Recommended Reading - May 2nd, 2021
- Exhausted-like CD8 T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects. Diggins K, et al. in JCI Insight, December 22, 2020
- Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity. Montgomery T, et al. in Proceedings of the National Academy of Sciences, November 3, 2020
- Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells. Fernandez-Ruiz, et al. in Nature Communications, November 25, 2020
- Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage. Johnnidis J, et al. in Science Immunology, January 15, 2021
- Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets. Gong Y, et al. in Cell Metabolism, January 5, 2021
