Maria Hadjifrangiskou, Ph.D.

Our special guest-Curator for December's Recommended Reading is Maria Hadjifrangiskou, Ph.D., an Associate Director  of VI4.


1. Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut. Reese AT, David LA, et al in eLife, June 19, 2018

2. Regulated Stochasticity in a Bacterial Signaling Network Permits Tolerance to a Rapid Environmental Change. Carey JN, Goulian M, et al in Cell, March 1, 2018

3. Bacteriophages are more virulent to bacteria with human cells than they are in bacterial culture; insights from HT-29 cells. Shan J, Clokie MRJ, et al in Nature, March 23, 2018

4. Candida albicans biofilm–induced vesicles confer drug resistance through matrix biogenesis. Zarnowski R, Andes DR, et al in PLOS Biology, October 8, 2018

This paper by Zarnowski et al., demonstrates that biofilm-specific extracellular vesicles (EV) produced by Candida albicans serve the community by facilitating the distribution of common goods such as extracellular matrix components. 

Reduced EV production by interfering with the ESCRT machinery reduces exopolysaccharide abundance and induces drug hyper-sensitivity.

5. Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions. Thurley K, Wu LF, Altschuler SJ in Cell, March 28, 2018

Modelling cellular conversations! From microbial cells to complex tissue micro-environments, one thing is common: signaling networks exist to facilitate cell-to-cell communication. Here is a scalable modeling framework that tackles cellular conversation using response-time distributions.