VI4 Recommended Reading

The fields of infection biology, immunobiology and inflammation research is varied and ever-expanding. Researchers the world over are making discoveries that contribute greatly to our collective understanding of health and disease. VI4 is committed to providing our members, students, and community resources to aid in knowledge-building in these core VI4 research areas. Please check out our current curated recommended reading list below from scientists across the country!

Recommended Reading - June 7th, 2019

VI4 Curation Team

  1. In Vivo Structures of the Helicobacter pylori cag Type IV Secretion System. Chang YW, Jensen G, et al in Cell Reports, April 17, 2019
  2. p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells. Ihry R, Kaykas A, et al in Nature Medicine, June 11, 2018
  3. Vesicle-Cloaked Virus Clusters Are Optimal Units for Inter-organismal Viral Transmission. Santiana M, Altan-Bonnet N, et al in Cell Host & Microbe, August 8, 2018
  4. Unique Patterns and Biogeochemical Relevance of Two-Component Sensing in Marine Bacteria. Held NA, Saito MA, et al in M Systems - ASM, February 5, 2019
  5. Neutrophils: New insights and open questions. Ley K, Catz SD, et al in Science Immunology, December 7, 2018

Recommended Reading - May 10th, 2019

VI4 Curation Team

  1. Translocation of a gut pathobiont drives autoimmunity in mice and humans. Vieira SM, Goodman AL, Kriegel MA, et al in Science, March 9, 2018
  2. Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis. Sjodt M, Rudner DZ, Kruse AC, et al in Nature, April 5, 2018
  3. Spatial determinants of quorum signaling in a Pseudomonas aeruginosa infection model. Darch S, Shear JB, Whiteley M, et al in PNAS, April 17, 2018
  4. Bacterial sensors define intracellular free energies for correct enzyme metalation. Osman D, Chivers PT, Robinson NJ, et al in Nature: Chemical Biology, January 28, 2019
  5. Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers. Gruosso T, Haibe-Kains B, Park M, et al in The Journal of Clinical Investigation, February 12, 2019

Recommended Reading - March 18th, 2019

VI4 Curation Team

Recommended Reading - February 22nd, 2019

VI4 Curation Team

Recommended Reading - January 25th, 2019

VI4 Curation Team

  1. Disruption of staphylococcal aggregation protects against lethal lung injury. Hook J, Bhattacharya J, et al in The Journal of Clinical Investigation, February 12, 2018
  2. Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles. Kayama H, Takeda K, et al in PNAS, August 14, 2018

  3. Precision editing of the gut microbiota ameliorates colitis. Zhu W, Winter SE, et al in Nature, January 11, 2018

  4. Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism. Trompette A, Marsland BJ, et al in Cell Immunity, May 15, 2018

  5. Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination. Burnett D, Goodnow CC, et al in Science, April 13, 2018

Recommended Reading - Sugar and Spice Edition

Maria Hadjifrangiskou, Ph.D.

Our special guest-Curator for December's Recommended Reading is Maria Hadjifrangiskou, Ph.D., an Associate Director  of VI4.


1. Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut. Reese AT, David LA, et al in eLife, June 19, 2018

2. Regulated Stochasticity in a Bacterial Signaling Network Permits Tolerance to a Rapid Environmental Change. Carey JN, Goulian M, et al in Cell, March 1, 2018

3. Bacteriophages are more virulent to bacteria with human cells than they are in bacterial culture; insights from HT-29 cells. Shan J, Clokie MRJ, et al in Nature, March 23, 2018

4. Candida albicans biofilm–induced vesicles confer drug resistance through matrix biogenesis. Zarnowski R, Andes DR, et al in PLOS Biology, October 8, 2018

This paper by Zarnowski et al., demonstrates that biofilm-specific extracellular vesicles (EV) produced by Candida albicans serve the community by facilitating the distribution of common goods such as extracellular matrix components. 

Reduced EV production by interfering with the ESCRT machinery reduces exopolysaccharide abundance and induces drug hyper-sensitivity.

5. Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions. Thurley K, Wu LF, Altschuler SJ in Cell, March 28, 2018

Modelling cellular conversations! From microbial cells to complex tissue micro-environments, one thing is common: signaling networks exist to facilitate cell-to-cell communication. Here is a scalable modeling framework that tackles cellular conversation using response-time distributions.