Vanderbilt Institute for Infection, Immunology and Inflammation

1. A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii. Luna B, et al. in Nature Microbiology, June 8, 2020
2. SARS-CoV-2 infection protects against rechallenge in rhesus macaques. Chandrashekar A, et al. in Science, May 20, 2020
3. Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation. Sinha S, et al. in Cell Host & Microbe, April 8, 2020
4. The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Nejman D, et al. in Science, May 29, 2020
5. Bcl6 and Blimp1 Reciprocally Regulate ST2 + Treg-cell Development in the Context of Allergic Airway Inflammation. Koh B, et al. in The Journal of Allergy and Clinical Immunology, March 13, 2020

1. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sheahan T, et al. in Science Translational Medicine, April 6, 2020
2. Spatially Distinct Physiology of Bacteroides Fragilis Within the Proximal Colon of Gnotobiotic Mice. Donaldson G, et al. in Nature Microbiology, March 9, 2020
3. Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9. Harman J, et al. in eLife, April 7, 2020
4. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Jingyou Y, et al. in Science, May 20, 2020
5. ILC2s Amplify PD-1 Blockade by Activating Tissue-Specific Cancer Immunity. Moral JA, et al. in Nature, February 19, 2020

1. Sex-specific adipose tissue imprinting of regulatory T cells. Vasanthakumar A, et al. in Nature, February 26, 2020
2. Metabolites released from apoptotic cells act as tissue messengers. Medina C, et al. in Nature, March 18, 2020
3. Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. Zhu J, et al. in Cell Metabolism, November 5, 2019
4. Decoy exosomes provide protection against bacterial toxins. Keller M D, et al. in Nature, March 4, 2020
5. Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity. McGinty J, et al. in Cell Press, March 17, 2020
6. Collective Viral Spread Mediated by Virion Aggregates Promotes the Evolution of Defective Interfering Particles.. Andreu-Moreno, Sanjuan, Rafael in American Society for Microbiology Journal, January 7, 2020
7. JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor. O'Hara BA, et al. in PLOS Pathogens, March 4, 2020
8. Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides Ovatus and Are Modifiable by Gut Microbiota Manipulation. Yang C, et al. in Cell Host & Microbe, February 18, 2020
9. Long-term dietary intervention reveals resilience of the gut microbiota despite changes in diet and weight. Fragiadais G, et al. in The American Journal of Clinical Nutrition, March 18, 2020
10. Commensal Bacteria Modulate Immunoglobulin A Binding in Response to Host Nutrition. Huus K, et al. in Cell Host & Microbe, April 13, 2020

1. N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I. Lu M, et al. in Nature, April 5, 2020
2. Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. Saunders K, et al. in Science, December 6, 2019
3. Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung. Sajti E, et al. in Nature Immunology, January 20, 2020
4. B cells and tertiary lymphoid structures promote immunotherapy response. Helmink B, et al. in Nature, January 15, 2020
5. c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies. Bernink J, et al. in Nature Immunology, November 13, 2019
6. Structure‐Guided Design of a Group B Streptococcus Type III Synthetic Glycan–Conjugate Vaccine. Oldrini D, et al. in Chemistry Europe, February 14, 2020
7. Antirotavirus IgA seroconversion rates in children who receive concomitant oral poliovirus vaccine: A secondary, pooled analysis of Phase II and III trial data from 33 countries. Baker JM, et al. in PLOS Medicine, December 30, 2019
8. An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products. de Los Reyes J M, et al. in Science, April 22, 2020
9. Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. Pleguezuelos-Manzano C, et al. in Nature, February 27, 2020
10. Antibiotic Degradation by Commensal Microbes Shields Pathogens. Gjonbalaj M, et al. in American Society for Microbiology Journal, January 14, 2020

1. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Wrapp D, et al. in Science, March 13, 2020
2. MAIT cells are imprinted by the microbiota in early life and promote tissue repair. Constantinides, M, et al. in Science, October 25, 2019
3. Optogenetic manipulation of calcium signals in single T cells in vivo. Bohineust A, et al. in Nature, March 2, 2020
4. Live-animal imaging of native haematopoietic stem and progenitor cells. Christodoulou C, et al. in Nature, February 5, 2020
5. Targeting of temperate phages drives loss of type I CRISPR–Cas systems. Rollie C, et al. in Nature, January 22, 2020
6. Combinatorial selection in amoebal hosts drives the evolution of the human pathogen Legionella pneumophila. Park J, et al. in Nature, January 27, 2020
7. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Leone R, et al. in Science, Novemeber 22, 2019
8. Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells. Wang X, et al. in Immunity, February 11, 2020
9. Enhanced immunogenicity of mitochondrial-localized proteins in cancer cells. Prota G, et al. in Cancer Immunology Research, March 12, 2020
10. Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism. Duscha A, et al. in ScienceDirect, March 19, 2020

1. FPR1 is the plague receptor on host immune cells. Osei-Owusu P, et al. in Nature, September 18, 2019
2. Structure elucidation of colibactin and its DNA cross-links. Xue M, et al. in Science, September 6, 2019
3. Ketogenic diet activates protective γδ T cell responses against influenza virus infection. Goldberg EL, et al. in Science, November 11, 2019
4. Staphylococcus aureus toxin suppresses antigen-specific T cell responses. Lee B, et al. in The Journal of Clinical Investigation, December 24, 2019
5. Peripheral T cell expansion predicts tumour infiltration and clinical response. Wu TD, et al. in Nature, February 26, 2020

Bonus Recs!

1. Peritoneal GATA6+ macrophages function as a portal for Staphylococcus aureus dissemination. Jorch S, et al. in The Journal of Clinical Investigation, September 23, 2019
2. Microbial metabolites control the thymic development of mucosal-associated invariant T cells. Legoux F, et al. in Science, October 10, 2019
3. A metagenomic strategy for harnessing the chemical repertoire of the human microbiome. Sugimoto Y, et al. in Science, December 13, 2019
4. Simulation modelling for immunologists. Handel A, et al. in Nature, December 5, 2019
5. Improved protein structure prediction using potentials from deep learning. Senior A W, et al. in Nature, January 15, 2020

1. Dietary Intake Regulates the Circulation Inflammatory monocyte Pool. Jordan S, et al. in Cell, August 22, 2019
2. Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Duan Y, et al. in Nature, November 13, 2019
3. Metabolic regulation of gene expression by histone lactylation. Zhang D, et al. in Nature, October 23, 2019
4. Cyclophilin A protects HIV-1 from restriction by human TRIM5a. Kim K, et al. in Nature Microbiology, December 4, 2019
5. Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells. Hoffman D, et al. in Science, January 17, 2020

1. Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus. Kim S, et al. in Nature, August 21, 2019
2. Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis. Dai J, et al. in Journal of Experimental Medicine, September 23, 2019
3. Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche. Lewin G, et al. in Cell Press, September 24, 2019
4. Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation. Nagashima H, et al. in Science Direct, October 15, 2019
5. Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens. Carfrae L, et al. in Nature, October 28, 2019

1. Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling. Sangjin Kim, et al. in Cell Press, September 19, 2019
2. TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors. Guerin M, et al. in Nature, September 11, 2019
3. Large-scale identification of pathogen essential genes during coinfection with sympatric and allopatric microbes. Lewin G, et al. in PNAS, September 24, 2019
4. Bulk tissue cell type deconvolution with multi-subject single-cell expression reference. Wang X, et al. in Nature, January 22, 2019
5. Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate. Mani V, et al. in Science, October 11, 2019

1. Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory. Blelloch R, Poggio M, et al. in Cell Reports, April 4, 2019
2. Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ. Baldridge MT, Ingle H, et al. in Nature, April 1, 2019
3. Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade. Jacquelot N, et al. in Nature, September 3, 2019
4. Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells. Zalis E, et al. in American Society for Microbiology, September 17, 2019
5. The evolution of antibiotic resistance: Clinically relevant evolution studies are needed to help fight the spread of antibiotic resistance. Rekdal V, et al in Science, September 13, 2019