HIV/AIDS; antiretroviral therapy; mitochondrial genomics; oxidant stress; drug abuse
As an Infectious Diseases Physician Scientist, my research has been focused on improving the lives of HIV-infected individuals by imporving long-term outcomes of infection and treatment. This work includes collaborations with the AIDS Clinical Trials Group (ACTG), the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) group, and teams of multi-disciplinary investigators, and has bridged outcomes-epidemiology research, translational research, and clinical trials. This work has led to successful NIH-funded grants on which I have served as principal investigator or co-investigator. I have a strong track record of successfully leading and contributing to collaborative clinical-translational research in inflammation, oxidative stress, and genomics that has produced peer-reviewed publications of high relevance.
Translational and outcomes research in HIV; toxicity of antiretroviral therapy, particularly metabolic complications; pharmacogenomics of antiretroviral toxicity, particularly mitochondrial genetics and oxidant stress; use of large databases to evaluate antiretroviral utilization and outcomes.