Tina M. Iverson, Ph.D.

Associate Professor of Pharmacology
Associate Professor of Biochemistry

460 RRB; Department of Pharmacology, Vanderbilt University Medical Center
2300 Pierce Ave
Nashville
Tennessee
37232-6600
(615) 322-7817
Lab Phone
(615) 322-8721

Information encoding in proteins

Research Description

In humans, transmembrane signaling coordinates tissue and organ function. Inappropriate signaling is associated with numerous diseases, such as heart disease and cancer. All known transmembrane signaling processes require the formation of transient complexes between a membrane-spanning protein and an intracellular binding partner. These transient complexes are similar in some respects to transition states in chemical reactions, i.e. they are unstable, but essential for signaling to occur. Understanding the molecular details of these complexes is important for a complete view of biological signaling. To reveal how information is transferred across a membrane, we are performing x-ray crystallographic analysis of several model systems.

Publications on PubMed.gov