Thomas M. Aune, Ph.D.

Professor of Medicine
Associate Professor of Pathology, Microbiology & Immunology

T-3113 Medical Center North
1161 21st Avenue South
Nashville
Tennessee
37232-2681
615-322-4746

Functional genomic and epigenetic approaches to understand gene regulation

Research Description

Our research focuses on the use of functional genomic and epigenetic approaches to understand gene regulation.  Our interests range from detailed mechanistic studies of the interferon-gamma gene, a key cytokine produced by cells of the innate and adaptive immune system, to the use of these approaches to gain new insights into human disease.  In addition, we have begun to focus our attention on long noncoding RNAs (lncRNAs) and other species of RNAs that do not code for proteins.  We have developed computational and analytic pipelines to identify these RNA species and interrogate their functions in the immune system.  This includes the recognition that multiple lncRNA species are transcribed from key genetic loci that confer risk for developing human inflammatory disease.

Publications on PubMed.gov