Michael Miller, M.D., Ph.D.
Inflammation, Acute Respiratory Distress Syndrome, Superoxide Signaling, Endothelial Dysfunction
My lab’s research focuses on the effects of the redox environment, its modulators, and their functional outcome on cellular and animal models of acute respiratory distress syndrome (ARDS). His work is focused on building upon the molecular pathways associated with the inflammatory response characteristic of the development of ARDS. Specifically, he is investigating extracellular superoxide dismutase (ecSOD), an enzyme the catalyzes superoxide to hydrogen peroxide, and how ecSOD modulates pro-inflammatory signaling in the NF-kB pathway. Additionally, he is seeking to determine the functional implications of ecSOD localization, its role in endothelial dysfunction, and how its interaction with the extracellular matrix alters its signaling properties.