Matt Alexander, M.D., Ph.D.
Hypertension, cardiovascular disease, immunology, vascular biology
Dr. Alexander’s laboratory is focused on the role of adaptive immunity in the pathogenesis of hypertension and associated cardiovascular disease. Current projects are focused on the role of counter-regulatory immune mechanisms in hypertension, including determining the role of novel regulatory T cell subsets in the pathogenesis of hypertension and microvascular dysfunction. We perform cutting edge basic and translational research integrating vascular biology and immunology using a variety of approaches including molecular biology, physiology, highly dimensional single cell analysis, and human genetics. Our laboratory is also integrated with the translational research infrastructure in the Divisions of Clinical Pharmacology and Cardiovascular Medicine to enable novel studies on human tissues and cells. Ultimately, the goal of Alexander laboratory is to fundamentally advance our understanding of hypertension and related cardiovascular diseases to develop new therapies for the benefit of the tremendous number of individuals affected by these conditions.