Acute lung injury and the acute respiratory distress syndrome
Dr. Ciara Shaver's laboratory is focused on understanding the mechanisms of acute lung injury and the acute respiratory distress syndrome (ARDS). Her scientific approach combines data from multiple animal models of acute lung injury with translational data from patients with ARDS. Currently, Dr. Shaver's primary focus is to understand the inflammatory consequences of extracellular hemoglobin in the airspace, particularly focusing on the role of macrophage subpopulations in regulating immune responses in the lung. Her previous graduate work investigated the interactions between bacterial exotoxins and innate immune cells during acute bacterial pneumonia. Dr. Shaver’s clinical interest is in lung transplantation with a particular focus on the early postoperative events that predict long-term outcomes. Dr. Shaver is currently funded by a K08 and a Parker B. Francis Fellowship in Pulmonary Research.