Baregamian Lab News

Baregamian Laboratory team's robust publishing efforts

The research team is led by Naira Baregamian, MD, FACS, assistant professor of Surgery in the Division of Surgical Oncology and Endocrine Surgery. Other team members include Sekhar Konjeti, PhD, staff scientist and Sriram Cyr, medical student. The Baregamian research lab focuses on metastatic papillary thyroid carcinomas, more specifically the metabolic rewiring of tumor microenvironment that drives tumor aggressiveness.

Recent Publications

Metabolism of Parathyroid Organoids

Konjeti R. Sekhar, Simona G. Codreanu, Olivia C. Williams, Jeffrey C. Rathmell, W. Kimryn Rathmell, John A. McLean, Stacy D. Sherrod, Naira Baregamian

Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer.

Sekhar KR, Hanna DN, Cyr S, Baechle JJ, Kuravi S, Balusu R, Rathmell K, Baregamian N.  Sci Rep. 2022, 12(1):19396. doi: 10.1038/s41598-022-23906-2. PMID: 36371529

Ferroptosis Inducers in Thyroid Cancer.

Sekhar KR, Cyr S, Baregamian N. World J Surg. 2022.  doi: 10.1007/s00268-022-06738-z. PMID: 36195678

Engineering functional 3-dimensional patient-derived endocrine organoids for broad multiplatform applications.

Baregamian N, Sekhar KR, Krystofiak ES, Vinogradova M, Thomas G, Mannoh E, Solórzano CC, Kiernan CM, Mahadevan-Jansen A, Abumrad N, Freeman ML, Weiss VL, Rathmell JC, Rathmell WK. Surgery. 2022, 15:S0039-6060(22)00814-5. doi: 10.1016/j.surg.2022.09.027. PMID: 36400581

Evaluation of the Molecular Landscape of Pediatric Thyroid Nodules and Use of a Multigene Genomic Classifier in Children.

Gallant JN, Chen SC, Ortega CA, Rohde SL, Belcher RH, Netterville JL, Baregamian N, Wang H, Liang J, Ye F, Nikiforov YE, Nikiforova MN, Weiss VL. JAMA Oncol. 2022 Sep 1;8(9):1323-1327. doi: 10.1001/jamaoncol.2022.1655. PMID: 35679040

Multiplatform computational analysis of mast cells in adrenocortical carcinoma tumor microenvironment.

Baechle JJ, Hanna DN, Sekhar KR, Rathmell JC, Rathmell WK, Baregamian N. Surgery. 2022 Jan;171(1):111-118. doi: 10.1016/j.surg.2021.04.045. PMID: 34261605

Label-Free Enhancement of Adrenal Gland Visualization Using Near-Infrared Autofluorescence for Surgical Guidance.

Thomas G, Kiernan CM, Willmon PA, Haugen E, Luckenbaugh AN, Barocas DA, Baregamian N, Mahadevan-Jansen A, Solόrzano CC.  World J Surg. 2022,  Oct 2. doi: 10.1007/s00268-022-06755-y. PMID: 36184672

The use of an educational time-out in thyroid and parathyroid surgery to move the needle in periprocedural education.

Lillemoe HA, Hanna DN, Baregamian N, Solórzano CC, Terhune KP, Geevarghese SK, Kiernan CM. Surgery. 2022,  7:S0039-6060(22)00619-5. doi: 10.1016/j.surg.2022.07.027. PMID: 36216620