DDRC Publications 2017-2021

DDRC PUBLICATIONS 2017-2021

Members' names and VDDRC Research Group affiliations are bolded. 

Gastrointestinal Infections and Inflammation (GI), Progenitor Cells, Development, Regeneration and Pre-malignant lesions (PC), and Obesity Metabolism, and Nutrition (OMN)

Pilot and Feasibility recipients in the last 10 years are bolded and in italics.

  PMC PUBLICATION
1 PMC8082271 Amy C Engevik, Evan S Krystofiak, Izumi Kaji, Anne R Meyer, Victoria G Weis, Anna Goldstein, Alexander W Coutts, Tamene Melkamu, Milena Saqui-Salces, James R Goldenring (PC). Recruitment of polarity complexes and tight junction proteins to the site of apical bulk endocytosis. Cell Mol Gastroenterol Hepatol 2021; 12(1):59-80. PMC8082271.
2 PMC8103698 Sydni Caet Smith, Jennifer Gribble, Julia R Diller, Michelle A Wiebe, Timothy W Thoner, Mark R Denison, Kristen M Ogden (GI). Reovirus RNA recombination is sequence directed and generates internally deleted defective genome segments during passage. J Virol 2021; 95(8):e02181-20. PMC8103698.
3 PMC8125609 Michael W Hess, Iris M Krainer, Przemyslaw A Filipek, Barbara Witting, Karin Gutleben, Ilja Vietor, Heinz Zoller, Denis Aldrian, Ekkehard Sturm, James R Goldenring (PC) Andreas R Janecke, Thomas Muller, Lukas Huber, Georg F Vogel. Advanced microscopy for liver and gut ultrastructural pathology in patients with MVID and PFIC caused by MYO5B mutations. J Clin Med; 2021 Apr 28:10(9):1901. doi: 10.3390/jcm1091901. PMID: 33924896. PMCID PMC8125609.
4 NIHMS1704883 Izumi Kaji, Joseph T Roland, Masahiko Watanabe, Amy C Engevik, Anna E Goldstein, Craig A Hodges, James R Goldenring (PC). Lysophosphatidic acid increases maturation of brush borders and SGLT1 activity in MYO5B-deficient mice, a model of microvillus inclusion disease. Gastroenterology 159(4):1390-1405.e20, 2020; NIHMS1704883.
5 PMC7410075 Carolina Pinzon-Guzman, Sreedhara Sangadala, Katherine M Riera, Evgenya Y Popova, Elizabeth Manning, Won Jae Huh (PC), Matthew S Alexander, Julia S Shelton, Scott D Boden, James R Goldenring (PC). Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia. J Clin Invest 130(8):4396-4410, 2020; PMC7410075.
6 PMC7518420 Mary C Macedonia, Julia L Drewes, Nicholas O Markham (GI), Alan J Simmons, Joseph T Roland, Paige N Vega, Cherie' R Scurrah, Robert J Coffey (PC), Martha J Shrubsole (OMN), Cynthia L Sears, Ken S Lau (PC). Clinically adaptable polymer enables simultaneous spatial analysis of colonic tissues and biofilms. NPJ Biofilms Microbiomes 6(1):33, 2020; PMC7518420.
7 PMC7084131 Michael J Sheedlo, David M Anderson, Audrey K Thomas, D Borden Lacy (GI). Structural elucidation of the transferase toxin reveals a single-site binding mode for the enzyme. Proc Natl Acad Sci U S A 117(11):6139-6144, 2020; PMC7084131.
8 PMC7104382 John Tam, Simoun Icho, Evelyn Utama, Kathleen E Orrell, Rodolfo F Gómez-Biagi, Casey M Theriot, Heather K Kroh, Stacey A Rutherford, D Borden Lacy (GI), Roman A Melnyk. Intestinal bile acids directly modulate the structure and function of TcdB toxin. Proc Natl Acad Sci U S A 117(12):6792-6800, 2020; PMC7104382.
9 PMC7149309 Steven J Mileto, Thierry Jardé, Kevin O Childress, Jaime L Jensen, Ashleigh P Rogers, Genevieve Kerr, Melanie L Hutton, Michael J Sheedlo, Sarah C Bloch, John A Shupe, Katja Horvay, Tracey Flores, Rebekah Engel, Simon Wilkins, Paul J McMurrick, D Borden Lacy (GI), Helen E Abud, Dena Lyras. Infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease. Proc Natl Acad Sci U S A 117(14):8064-8073, 2020; PMC7149309.
10 PMC7363140 Myoung Soo Choi, Maura J Graves, Samaneh Matoo, Zachary A Storad, Rawnag A El Sheikh Idris, Meredith L Weck, Zachary B Smith, Matthew J Tyska (PC), Scott W Crawley. The small EF-hand protein CALML4 functions as a critical myosin light chain within the intermicrovillar adhesion complex. J Biol Chem 295(28):9281-9296, 2020; PMC7363140.
11 PMC7240096 Rhonda R Caston, Johanna C Sierra, Nora J Foegeding, Mandy D Truelock, Anne M Campbell, Arwen E Frick-Cheng, Diane Bimczok, Keith T Wilson (GI), Mark S McClain (GI), Timothy L Cover (GI). Functional properties of VacA toxin m1 and m2 variants. Infect Immun 2020; 88(6):e00032-20. PMC7240096.
12 PMC7330859 Feng Du, Tianyu Cao, Huahong Xie, Ting Li, Lina Sun, Hao Liu, Hao Guo, Xin Wang, Qi Liu, Taewan Kim, Jeffrey L Franklin (PC), Ramona Graves-Deal, Weili Han, Zuhong Tian, Minghui Ge, Yongzhan Nie, Daiming Fan, Robert J Coffey (PC), Yuanyuan Lu, Xiaodi Zhao. KRAS Mutation-Responsive mir-139-5p inhibits colorectal cancer progression and is repressed by Wnt signaling. Theranostics 10(16):7335-7350, 2020; PMC7330859.
13 PMC8010636 Katherine M Riera, Bogun Jang, Jimin Min, Joseph T Roland, Qing Yang, William T Fesmire, Sophie Camilleri-Broet, Lorenzo Ferri, Woo H Kim, Eunyoung Choi (PC), James R Goldenring (PC). Trop2 is upregulated in the transition to dysplasia in the metaplastic gastric mucosa. J Pathol 251(3):336-347, 2020; PMC8010636.
14 PMC7348062 Allison S Cohen, Ling Geng, Ping Zhao, Allie Fu, Michael L Schulte, Ramona Graves-Deal, M Kay Washington (OMN), Jordan Berlin (PC), Robert J Coffey (PC), H Charles Manning (PC). Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer. Transl Oncol 13(10):100828, 2020; PMC7348062.
15 PMC7455142 Xiao Zhang, Sheila Bandyopadhyay, Leandro P Araujo, Kevin Tong, Juan Flores, Daniel Laubitz, Yanlin Zhao, George Yap, Jingren Wang, Qingze Zou, Ronaldo P Ferraris, Lanjing Zhang, Wenwei Hu, Edward M Bonder, Pawel R Kiela, Robert J Coffey (PC), Michael Verzi, Ivaylo I Ivanov, Nan Gao. Elevating EGFR-MAPK program by a non-conventional Cdc42 enhances intestinal epithelial survival and regeneration. JCI Insight 2020; PMC7455142.
16 PMC7455083 Shan Wang, Ariel Raybuck, Eileen Shiuan, Sung Hoon Cho, Qingfei Wang, Dana M Brantley-Sieders, Deanna Edwards, Margaret M Allaman, James Nathan, Keith T Wilson (GI), David DeNardo, Siyuan Zhang, Rebecca Cook, Mark Boothby, Jin Chen. Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity. JCI Insight 5(15), 2020; PMC7455083.
17 PMC7426874 Matthew E Bechard, Rana Smalling, Akimasa Hayashi, Yi Zhong, Anna E Word, Sydney L Campbell, Amanda V Tran, Vivian L Weiss, Christine Iacobuzio-Donahue, Kathryn E Wellen, Oliver G McDonald (PC). Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis. Nat Commun 11(1):4055, 2020; PMC7426874.
18 PMC7460588 Chen Shen, Anmada Nayak, Ricardo A Melendez, Daniel T Wynn, Joshua Jackson, Ethan Lee (PC), Yashi Ahmed, David J Robbins. Casein kinase 1α as a regulator of Wnt-driven cancer. Int J Mol Sci 21(16), 2020; PMC7460588.
19 PMC7441315 Yanheng Chen, Donald Sheppard, Xingchen Dong, Xiangming Hu, Meihua Chen, Ruichuan Chen, Jayati Chakrabarti, Yana Zavros, Richard M Peek (GI), Lin-Feng Chen. H. pylori infection confers resistance to apoptosis via Brd4-dependent BIRC3 eRNA synthesis. Cell Death Dis 11(8):667, 2020; PMC7441315.
20 PMC7519665 Scott A Hinger, Jessica J Abner, Jeffrey L Franklin (PC), Dennis K Jeppesen, Robert J Coffey (PC), James G Patton. Rab13 regulates sEV secretion in mutant KRAS colorectal cancer cells. Sci Rep 10(1):15804, 2020; PMC7519665.
21 PMC7542348 Peter A Kropp, Gabrielle V Rushing, Asa A Brockman, Erin N Z Yu, Rebecca A Ihrie, Maureen Gannon (PC). Unexpected effects of ivermectin and selamectin on inducible Cre activity in mice. Lab Anim Res 36:36, 2020; PMC7542348.
22 PMC7584215 Jaime L Jensen, Shavait Yamini, Arne Rietsch, Benjamin W Spiller (GI). The structure of the Type III secretion system export gate with CdsO, an ATPase lever arm. PLoS Pathog 16(10):e1008923, 2020; PMC7584215.
23 PMC7705319 Meredith L Weck, Scott W Crawley, Matthew J Tyska (PC). A heterologous in-cell assay for investigating intermicrovillar adhesion complex interactions reveals a novel protrusion length-matching mechanism. J Biol Chem 295(48):16191-16206, 2020; PMC7705319.
24 PMC7888191 Ryota Masuzaki, Kevin C Ray, Joseph Roland, Roy Zent, Youngmin A Lee (GI), Seth J Karp (PC). Integrin β1 establishes liver microstructure and modulates transforming growth factor β during liver development and regeneration. Am J Pathol 2020; 191(2):309-319. PMC7888191.
25 PMC6938649 Mariana I Capurro, Laura K Greenfield, Akriti Prashar, Sunny Xia, Majd Abdullah, Harikesh Wong, Xi Zoe Zhong, Nina Bertaux-Skeirik, Jayati Chakrabarti, Iram Siddiqui, Catherine O'Brien, Xianping Dong, Lisa Robinson, Richard M Peek (GI), Dana J Philpott, Yana Zavros, Michael Helmrath, Nicola L Jones. VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1. Nat Microbiol 2019; PMC6938649.
26 PMC6620282 Mohammed Soutto, Zheng Chen, Ajaz A Bhat, Lihong Wang, Shoumin Zhu, Ahmed Gomaa, Andreia Bates, Nadeem S Bhat, Dunfa Peng, Abbes Belkhiri (PC), M Blanca Piazuelo (GI), M Kay Washington (OMN), Xi Chen Steven, Richard Peek (GI), Wael El-Rifai (PC). Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia. Nat Commun 10(1):3039, 2019; PMC6620282.
27 PMC6765285 Lydia E Wroblewski, Eunyoung Choi (PC), Christine Petersen, Alberto G Delgado, M Blanca Piazuelo (GI), Judith Romero-Gallo, Tyler L Lantz, Yana Zavros, Robert J Coffey (PC), James R Goldenring (PC), Anne E Zemper, Richard M Peek (GI). Targeted mobilization of LRIG1 gastric epithelial stem cell populations by a carcinogenic type IV secretion system. Proc Natl Acad Sci U S A 2019; 116(39):19652-19658. PMC6765285.
28  PMC6925542 Kevin M Byrd, Natalie C Piehl, Jeet H Patel, Won Jae Huh (PC), Inês Sequeira, Kendall J Lough, Bethany L Wagner, Pauline Marangoni, Fiona M Watt, Ophir D Klein, Robert J Coffey (PC), Scott E Williams. Heterogeneity within stratified epithelial stem cell populations maintains the oral mucosa in response to physiological stress. Cell Stem Cell 25(6):814-829.e6, 2019; PMC6925542.
29 PMC7103561 Won Jae Huh (PC), Hiroaki Niitsu, Brandon Carney, Eliot T McKinley, Jacob L Houghton (PC), Robert J Coffey (PC). Identification and characterization of unique neutralizing antibodies to mouse EGF receptor. Gastroenterology 2019; 158(5):1500-1502. PMC7103561.
30 PMC6368861 Lihong Wang-Bishop, Zheng Chen, Ahmed Gomaa, Albert Craig Lockhart, Safia Salaria, Jialiang Wang, Keeli B Lewis, Jeffrey Ecsedy, Kay Washington (OMN), Robert Daniel Beauchamp (PC), Wael El-Rifai (PC). Inhibition of AURKA reduces proliferation and survival of gastrointestinal cancer cells with activated KRAS by preventing activation of RPS6KB1. Gastroenterology 156(3):662-675.e7, 2019; PMC6368861.
31 PMC6416438 Kathryn M McCulloch, Izumi Yamakawa, David A Shifrin, Russell E McConnell, Nora J Foegeding, Prashant K Singh, Suli Mao, Matthew J Tyska (PC), Tina M Iverson (PC). An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding. J Biol Chem 294(10):3454-3463, 2019; PMC6416438.
32 PMC6327430 Zhangjian Zhou, Heng Lu, Shoumin Zhu, Ahmed Gomaa, Zheng Chen, Jin Yan, Kay Washington (OMN), Wael El-Rifai (PC), Chengxue Dang, Dunfa Peng. Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage. J Exp Clin Cancer Res 38(1):13, 2019; PMC6327430.
33 PMC6941354 Sarah P Short (GI), Joshua J Thompson, Anthony J Bilotta, Xi Chen, Frank L Revetta, M Kay Washington (OMN), Christopher S Williams (GI). Serine threonine kinase 17A maintains the epithelial state in colorectal cancer cells. Mol Cancer Res 17(4):882-894, 2019; PMC6941354.
34 PMC6434121 Nora J Foegeding, Krishnan Raghunathan, Anne M Campbell, Sun Wook Kim, Ken S Lau (PC), Anne K Kenworthy, Timothy L Cover (GI), Melanie D Ohi. Intracellular degradation of Helicobacter pylori VacA toxin as a determinant of gastric epithelial cell viability. Infect Immun 87(4), 2019; PMC6434121.
35 PMC6625667 Min Su, Amanda L Erwin, Anne M Campbell, Tasia M Pyburn, Lauren E Salay, Jessica L Hanks, D Borden Lacy (GI), David L Akey, Timothy L Cover (GI), Melanie D Ohi. Cryo-EM analysis reveals structural basis of Helicobacter pylori VacA toxin oligomerization. J Mol Biol 431(10):1956-1965, 2019; PMC6625667.
36 PMC6467488 Angela M Howard, Kimberly S LaFever, Aidan M Fenix, Cherie' R Scurrah, Ken S Lau (PC), Dylan T Burnette, Gautam Bhave, Nicholas Ferrell, Andrea Page-McCaw. DSS-induced damage to basement membranes is repaired by matrix replacement and crosslinking. J Cell Sci 132(7), 2019; PMC6467488.
37 PMC6599455 Joseph M Elsakr, Jennifer C Dunn, Katherine Tennant, Sifang Kathy Zhao, Karly Kroeten, Raymond C Pasek, Diana L Takahashi, Tyler A Dean, Digna R Velez Edwards, Carrie E McCurdy, Kjersti M Aagaard, Alvin C Powers, Jacob E Friedman, Paul Kievit, Maureen Gannon (PC). Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition. Mol Metab 2019; PMC6599455.
38 PMC6639157 Shoumin Zhu, Mohammed Soutto, Zheng Chen, M Blanca Piazuelo, M Kay Washington (OMN), Abbes Belkhiri (PC), Alexander Zaika (GI), Dunfa Peng, Wael El-Rifai (PC). Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells. Oncogene 38(29):5805-5816, 2019; PMC6639157.
39 PMC6615643 Ephrem G Kassa, Efrat Zlotkin-Rivkin, Gil Friedman, Rachana P Ramachandran, Naomi Melamed-Book, Aryeh M Weiss, Michael Belenky, Dana Reichmann, William Breuer, Ritesh Ranjan Pal, Ilan Rosenshine, Lynne A Lapierre, James R Goldenring (PC), Benjamin Aroeti. Enteropathogenic Escherichia coli remodels host endosomes to promote endocytic turnover and breakdown of surface polarity. PLoS Pathog 15(6):e1007851, 2019; PMC6615643.
40 PMC6594578 J Dylan Shropshire, Seth R Bordenstein (GI). Two-by-one model of cytoplasmic incompatibility: Synthetic recapitulation by transgenic expression of cifA and cifB in Drosophila. PLoS Genet 15(6):e1008221, 2019; PMC6594578.
41 PMC6889613 Chanjuan Shi (OMN), Fong Cheng Pan, Jessica N Kim, M Kay Washington (OMN), Chandrasekhar Padmanabhan, Christian T Meyer, Janel L Kopp, Maike Sander, Maureen Gannon (PC), R Daniel Beauchamp (PC), Christopher V Wright (PC), Anna L Means (PC). Differential cell susceptibilities to Kras in the setting of obstructive chronic pancreatitis. Cell Mol Gastroenterol Hepatol 2019; 8(4):579-594. PMC6889613.
42 PMC6726537 Heng Lu, Ajaz A Bhat, Dunfa Peng, Zheng Chen, Shoumin Zhu, Jun Hong, Selma Maacha, Jin Yan, David J Robbins, M Kay Washington (OMN), Abbes Belkhiri (PC), Wael El-Rifai (PC). APE1 upregulates MMP-14 via redox-sensitive ARF6-mediated recycling to promote cell invasion of esophageal adenocarcinoma. Cancer Res 79(17):4426-4438, 2019; PMC6726537.
43 PMC6881610 Takahiro Shimizu, Yoojin Sohn, Eunyoung Choi (PC), Christine P Petersen, Nripesh Prasad, James R Goldenring (PC). Decrease in miR-148a expression during initiation of chief cell transdifferentiation. Cell Mol Gastroenterol Hepatol 2019; PMC6881610.
44 PMC6811995 Sen Wang, Zheng Chen, Shoumin Zhu, Heng Lu, Dunfa Peng, Mohammed Soutto, Huma Naz, Richard Peek (GI), Hao Xu, Alexander Zaika, Zekuan Xu, Wael El-Rifai. PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer. Redox Biol 28:101319, 2019; PMC6811995.
45 PMC6736233 Jessamyn I Perlmutter, Sarah R Bordenstein (GI), Robert L Unckless, Daniel P LePage, Jason A Metcalf, Tom Hill, Julien Martinez, Francis M Jiggins, Seth R Bordenstein (GI). The phage gene wmk is a candidate for male killing by a bacterial endosymbiont. PLoS Pathog 15(9):e1007936, 2019; PMC6736233.
46 PMC6829668 Amy C Engevik, Izumi Kaji, Meagan M Postema, James J Faust, Anne R Meyer, Janice A Williams, Gillian N Fitz, Matthew J Tyska (PC), Jean M Wilson, James R Goldenring (PC). Loss of myosin Vb promotes apical bulk endocytosis in neonatal enterocytes. J Cell Biol 218(11):3647-3662, 2019; PMC6829668.
47 PMC6798121 Julia R Diller, Helen M Parrington, John T Patton, Kristen M Ogden (GI). Rotavirus species b encodes a functional fusion-associated small transmembrane protein. J Virol 93(20), 2019; PMC6798121.
48 PMC6942998 Chen Shen, Bin Li, Luisana Astudillo, Murray P Deutscher, Melanie H Cobb, Anthony J Capobianco, Ethan Lee (PC), David J Robbins. The CK1α activator pyrvinium enhances the catalytic efficiency of CK1α. Biochemistry 2019; PMC6942998.
49 PMC6574174 Leif R Neitzel, Zachary T Spencer, Anmada Nayak, Christopher S Cselenyi, Hassina Benchabane, CheyAnne Q Youngblood, Alya Zouaoui, Victoria Ng, Leah Stephens, Trevor Hann, James G Patton, David Robbins, Yashi Ahmed, Ethan Lee  (PC).  Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway. Mech Dev. 2019 Apr;156:20-31. doi: 10.1016/j.mod.2019.03.002. Epub 2019 Mar 20. PubMed PMID: 30904594; PubMed Central PMCID: PMC6574174.
50 PMC5834672 Jonathan D Brown (OMN), Zachary B Feldman, Sean P Doherty, Jaime M Reyes, Peter B Rahl, Charles Y Lin, Quanhu Sheng, Qiong Duan, Alexander J Federation, Andrew L Kung, Saptarsi M Haldar, Richard A Young, Jorge Plutzky, James E Bradner. BET bromodomain proteins regulate enhancer function during adipogenesis. Proc Natl Acad Sci U S A 115(9):2144-2149, 2018; PMC5834672.
51 PMC6205397 Yang Zhang, Alexander J Federation, Soomin Kim, John P O'Keefe, Mingyue Lun, Dongxi Xiang, Jonathan D Brown (OMN), Matthew L Steinhauser. Targeting nuclear receptor NR4A1-dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity. J Clin Invest 2018; 128(11):4898-4911.  PMC6205397.
52 PMC5777265 Heather K Kroh, Ramyavardhanee Chandrasekaran, Zhifen Zhang, Kim Rosenthal, Rob Woods, Xiaofang Jin, Andrew C Nyborg, G Jonah Rainey, Paul Warrener, Roman A Melnyk, Benjamin W Spiller (GI), D Borden Lacy (GI). A neutralizing antibody that blocks delivery of the enzymatic cargo of toxin TcdB into host cells. J Biol Chem 293(3):941-952, 2018; PMC5777265.
53 PMC5797493 Cameron Schlegel, Victoria G Weis, Byron C Knowles, Lynne A Lapierre, Martin G Martin, Paul Dickman, James R Goldenring (PC), Mitchell D Shub. Apical membrane alterations in non-intestinal organs in microvillus inclusion disease. Dig Dis Sci 63(2):356-365, 2018; PMC5797493.
54 PMC6009015 Kevin A Bockerstett, Luciana H Osaki, Christine P Petersen, Catherine W Cai, Chun Fung Wong, Thanh-Long M Nguyen, Eric L Ford, Daniel F Hoft, Jason C Mills, James R Goldenring (PC), Richard J DiPaolo. Interleukin-17A promotes parietal cell atrophy by inducing apoptosis. Cell Mol Gastroenterol Hepatol 5(4):678-690.e1, 2018; PMC6009015.
55 PMC5808116 Mona Tafreshi, Jyeswei Guan, Rebecca J Gorrell, Nicole Chew, Yue Xin, Virginie Deswaerte, Manfred Rohde, Roger J Daly, Richard M Peek (GI), Brendan J Jenkins, Elizabeth M Davies, Terry Kwok. Type IV secretion system and its adhesin subunit, CagL, mediate potent inflammatory responses in primary human endothelial cells. Front Cell Infect Microbiol 8:22, 2018; PMC5808116.
56 PMC6005374 James E Cassat (GI), Jessica L Moore, Kevin J Wilson, Zach Stark, Boone M Prentice, Raf Van de Plas, William J Perry, Yaofang Zhang, John Virostko, Daniel C Colvin, Kristie L Rose, Audra M Judd, Michelle L Reyzer, Jeffrey M Spraggins, Caroline M Grunenwald, John C Gore, Richard M Caprioli (PC), Eric P Skaar (GI). Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions. Sci Transl Med 10(432), 2018; PMC6005374.
57 PMC5948995 J Dylan Shropshire, Jungmin On, Emily M Layton, Helen Zhou, Seth R Bordenstein (GI). One prophage WO gene rescues cytoplasmic incompatibility in Drosophila melanogaster. Proc Natl Acad Sci U S A 115(19):4987-4991, 2018; PMC5948995.
58 PMC5913846 Krishnan Raghunathan, Nora J Foegeding, Anne M Campbell, Timothy L Cover (GI), Melanie D Ohi, Anne K Kenworthy. Determinants of raft partitioning of the Helicobacter pylori pore-forming toxin VacA. Infect Immun 86(5), 2018; PMC5913846.
59 PMC5954226 Emma C Skoog, Vasilios A Morikis, Miriam E Martin, Greg A Foster, Lucy P Cai, Lori M Hansen, Beibei Li, Jennifer A Gaddy (GI), Scott I Simon, Jay V Solnick. CagY-Dependent regulation of type IV secretion in Helicobacter pylori is associated with alterations in integrin binding. mBio 9(3), 2018; PMC5954226.
60 PMC5988964 Lisa J Funkhouser-Jones, Edward J van Opstal, Ananya Sharma, Seth R Bordenstein (GI). The maternal effect gene wds controls Wolbachia titer in Nasonia. Curr Biol 28(11):1692-1702.e6, 2018; PMC5988964.
61  PMC6031333 Victoria H Ng, Brian I Hang, Leah M Sawyer, Leif R Neitzel, Emily E Crispi, Kristie L Rose, Tessa M Popay, Alison Zhong, Laura A Lee, William P Tansey, Stacey Huppert, Ethan Lee (PC). Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling. J Cell Sci 131(10), 2018; PMC6031333.
62 PMC6309034 Carolina Pinzon-Guzman, Anne R Meyer, Rachel Wise, Eunyoung Choi (PC), Sureshkumar Muthupalani, Timothy C Wang, James G Fox, James R Goldenring (PC). Evaluation of lineage changes in the gastric mucosa following infection with Helicobacter pylori and specified intestinal flora in INS-GAS mice. J Histochem Cytochem 2018; 67(1):53-63. PMC6309034.
63 PMC6078348 Leif R Neitzel, Matthew R Broadus, Nailing Zhang, Leah Sawyer, Heather A Wallace, Julie A Merkle, Jeanne N Jodoin, Poojitha Sitaram, Emily E Crispi, William Rork, Laura A Lee, Duojia Pan, Kathleen L Gould, Andrea Page-McCaw, Ethan Lee (PC). Characterization of a null allele in Drosophila melanogaster. Biol Open 7(7), 2018; PMC6078348.
64 PMC6368528 Matthew R Broadus, Ethan Lee (PC). Chemical screening using cell-free Xenopus egg extract. Cold Spring Harb Protoc 2018(8), 2018; PMC6368528.
65 PMC6095027 Ryan M Allen, Shilin Zhao, Marisol A Ramirez Solano, Wanying Zhu (OMN), Danielle L Michell, Yuhuan Wang, Yu Shyr, Praveen Sethupathy, MacRae F Linton, Gregory A Graf, Quanhu Sheng, Kasey C Vickers (GI). Bioinformatic analysis of endogenous and exogenous small RNAs on lipoproteins. J Extracell Vesicles 7(1):1506198, 2018; PMC6095027.
66 PMC6126204 Selma Maacha, Jun Hong, Ariana von Lersner, Andries Zijlstra, Abbes Belkhiri (PC). AXL mediates esophageal adenocarcinoma cell invasion through regulation of extracellular acidification and lysosome trafficking. Neoplasia 20(10):1008-1022, 2018; PMC6126204.
67 PMC5673559 Facundo M Tonucci, Anabela Ferretti, Evangelina Almada, Pamela Cribb, Rodrigo Vena, Florencia Hidalgo, Cristian Favre, Matt J Tyska, Irina Kaverina, Maria C Larocca. Microtubules regulate brush border formation. J Cell Physiol. 2018 Feb;233(2):1468-1480. doi: 10.1002/jcp.26033.  PMID: 28548701; PMCID: PMC5673559.
68 PMC6191315 Cameron Schlegel, Lynne A Lapierre, Victoria G Weis, Janice A Williams, Izumi Kaji, Carolina Pinzon-Guzman, Nripesh Prasad, Braden Boone, Angela Jones, Hernan Correa, Shawn E Levy, Xianlin Han, Miao Wang, Kelly Thomsen, Sari Acra (OMN), James R Goldenring (PC). Reversible deficits in apical transporter trafficking associated with deficiency in diacylglycerol acyltransferase. Traffic 19(11):879-892, 2018; PMC6191315.
69 PMC5453701 Eliot T McKinley, Yunxia Sui, Yousef Al-Kofahi, Bryan A Millis, Matthew J Tyska (PC), Joseph T Roland, Alberto Santamaria-Pang, Christina L Ohland, Christian Jobin, Jeffrey L Franklin (PC), Ken S Lau (PC), Michael J Gerdes, Robert J Coffey (PC). Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity. JCI Insight 2(11), 2017; PMC5453701.
70 PMC5572896 E Danielle Dean (OMN), Mingyu Li, Nripesh Prasad, Scott N Wisniewski, Alison Von Deylen, Jason Spaeth, Lisette Maddison, Anthony Botros, Leslie R Sedgeman, Nadejda Bozadjieva, Olga Ilkayeva, Anastasia Coldren, Greg Poffenberger, Alena Shostak, Michael C Semich, Kristie I Aamodt, Neil Phillips, Hai Yan, Ernesto Bernal-Mizrachi, Jackie D Corbin, Kasey C Vickers (GI), Shawn E Levy, Chunhua Dai, Christopher Newgard, Wei Gu, Roland Stein, Wenbiao Chen, Alvin C Powers. Interrupted glucagon signaling reveals hepatic α cell axis and role for L-glutamine in α cell proliferation. Cell Metab 25(6):1362-1373.e5, 2017; PMC5572896.
71 PMC5384548 Sangho Jeong, Eunyoung Choi (PC), Christine P Petersen, Joseph T Roland, Alessandro Federico, Rossana Ippolito, Francesco P D'Armiento, Gerardo Nardone, Osamu Nagano, Hideyuki Saya, Marco Romano, James R Goldenring (PC). Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis. United European Gastroenterol J 5(1):37-44, 2017; PMC5384548.
72 PMC5368030 Yufang Ma, Lihong Wang, Leif R Neitzel, Sudan N Loganathan, Nan Tang, Lili Qin, Emily E Crispi, Yan Guo, Stefan Knapp, R Daniel Beauchamp (PC), Ethan Lee (PC), Jialiang Wang. The MAPK pathway regulates intrinsic resistance to BET inhibitors in colorectal cancer. Clin Cancer Res 23(8):2027-2037, 2017; PMC5368030.
73 PMC5283902 Victoria G Weis, Christine P Petersen, Jared A Weis, Anne R Meyer, Eunyoung Choi (PC), Jason C Mills, James R Goldenring (PC). Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am J Physiol Gastrointest Liver Physiol 312(1):G67-G76, 2017; PMC5283902.
74  PMC5383218 Rebecca McRae, Lynne A Lapierre, Elizabeth H Manning, James R Goldenring (PC). Rab11-FIP1 phosphorylation by MARK2 regulates polarity in MDCK cells. Cell Logist 7(1):e1271498, 2017; PMC5383218.
75 PMC5391185 Lynne A Lapierre, Elizabeth H Manning, Kenya M Mitchell, Cathy M Caldwell, James R Goldenring (PC). Interaction of phosphorylated Rab11-FIP2 with Eps15 regulates apical junction composition. Mol Biol Cell 28(8):1088-1100, 2017; PMC5391185.
76 PMC5501754 Dana M Hardbower, Lori A Coburn (OMN), Mohammad Asim, Kshipra Singh, Johanna C Sierra, Daniel P Barry, Alain P Gobert, M Blanca Piazuelo (GI), M Kay Washington (OMN), Keith T Wilson (GI). EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis. Oncogene 36(27):3807-3819, 2017; PMC5501754.
77 PMC5426844 Alina Starchenko, Ramona Graves-Deal, Yu-Ping Yang, Cunxi Li, Roy Zent, Bhuminder Singh (PC), Robert J Coffey (PC). Clustering of integrin α5 at the lateral membrane restores epithelial polarity in invasive colorectal cancer cells. Mol Biol Cell 28(10):1288-1300, 2017; PMC5426844.
78 PMC5422809 Subhash Kulkarni, Maria-Adelaide Micci, Jenna Leser, Changsik Shin, Shiue-Cheng Tang, Ya-Yuan Fu, Liansheng Liu, Qian Li, Monalee Saha, Cuiping Li, Grigori Enikolopov, Laren Becker, Nikolai Rakhilin, Michael Anderson, Xiling Shen, Xinzhong Dong, Manish J Butte, Hongjun Song, E Michelle Southard-Smith (PC), Raj P Kapur, Milena Bogunovic, Pankaj J Pasricha. Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis. Proc Natl Acad Sci U S A 114(18):E3709-E3718, 2017; PMC5422809.
79 PMC5693299 Georg F Vogel, Andreas R Janecke, Iris M Krainer, Karin Gutleben, Barbara Witting, Sally G Mitton, Sahar Mansour, Antje Ballauff, Joseph T Roland, Amy C Engevik, Ernest Cutz, Thomas Müller, James R Goldenring (PC), Lukas A Huber, Michael W Hess. Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with microvillus inclusion disease. Traffic 18(7):453-464, 2017; PMC5693299.
80 PMC5558269 Qiang Feng, Edward M Bonder, Amy C Engevik, Lanjing Zhang, Matthew J Tyska (PC), James R Goldenring (PC), Nan Gao. Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy. J Cell Sci 130(15):2491-2505, 2017; PMC5558269.
81 PMC5582835 Heather K Kroh, Ramyavardhanee Chandrasekaran, Kim Rosenthal, Rob Woods, Xiaofang Jin, Melanie D Ohi, Andrew C Nyborg, G Jonah Rainey, Paul Warrener, Benjamin W Spiller (GI), D Borden Lacy (GI). Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface. J Biol Chem 292(35):14401-14412, 2017; PMC5582835.
82 PMC5662261 Sun Wook Kim, Jonathan Ehrman, Mok-Ryeon Ahn, Jumpei Kondo, Andrea A Mancheno Lopez, Yun Sik Oh, Xander H Kim, Scott W Crawley, James R Goldenring (PC), Matthew J Tyska (PC), Erin C Rericha, Ken S Lau (PC). Shear stress induces noncanonical autophagy in intestinal epithelial monolayers. Mol Biol Cell 28(22):3043-3056, 2017; PMC5662261.
83 PMC5674895 Begum Erdogan, Mingfang Ao, Lauren M White, Anna L Means (PC), Bryson M Brewer, Lijie Yang, M Kay Washington (OMN), Chanjuan Shi (OMN), Omar E Franco, Alissa M Weaver, Simon W Hayward, Deyu Li, Donna J Webb. Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. J Cell Biol 216(11):3799-3816, 2017; PMC5674895.
84 PMC5715757 Menghua Xiong, Yan Bao, Xin Xu, Hua Wang, Zhiyuan Han, Zhiyu Wang, Yeqing Liu, Songyin Huang, Ziyuan Song, Jinjing Chen, Richard M Peek (GI), Lichen Yin, Lin-Feng Chen, Jianjun Cheng. Selective killing of with pH-responsive helix-coil conformation transitionable antimicrobial polypeptides. Proc Natl Acad Sci U S A 114(48):12675-12680, 2017; PMC5715757.
85 PMC8020481 Yilin Deng, Oliver G McDonald (PC), Anna L Means (PC), Richard M Peek (GI), M Kay Washington (OMN), Sari A Acra (OMN), D Brent Polk, Fang Yan (GI). Exposure to p40 in early life prevents intestinal inflammation in adulthood through inducing a long-lasting epigenetic imprint on TGFβ. Cell Mol Gastroenterol Hepatol 2021; 11(5):1327-1345. PMC8020481.
86 PMC8122068 Bradley I Reinfeld, Matthew Z Madden, Melissa M Wolf, Anna Chytil, Jackie E Bader, Andrew R Patterson, Ayaka Sugiura, Allison S Cohen, Ahmed Ali, Brian T Do, Alexander Muir, Caroline A Lewis, Rachel A Hongo, Kirsten L Young, Rachel E Brown, Vera M Todd, Tessa Huffstater, Abin Abraham, Richard T O'Neil, Matthew H Wilson, Fuxue Xin, M Noor Tantawy, W David Merryman, Rachelle W Johnson, Christopher S Williams (GI), Emily F Mason, Frank M Mason, Katherine E Beckermann, Matthew G Vander Heiden, H Charles Manning (PC), Jeffrey C Rathmell (OMN), W Kimryn Rathmell. Cell-programmed nutrient partitioning in the tumour microenvironment. Nature 2021; 593(7858):282-288. PMC8122068.
87 PMC8002522 Sung Won Lee, Hyun Jung Park, Jungmin Jeon, Yun Hoo Park, Tae-Cheol Kim, Sung Ho Jeon, Luck Van Kaer (GI), Seokmann Hong. Chromatic regulator SRG3 overexpression protects against LPS/D-Ga1N-induced sepsis by increasing IL10-producing macrophages and decreasing IFNy-producing NK cells in the liver. Int J Mol Sci. 2021 Mar 16;22(6):3043. doi: 10.3390/ijms22063043. PMID 3380975/PMCID: PMC8002522.
88 PMC7768197 Valerie P O'Brien, Amanda L Koehne, Julien Dubrulle, Armando E Rodriguez, Christina K Leverich, V Paul Kong, Jean S Campbell, Robert H Pierce, James R Goldenring (PC), Eunyoung Choi (PC), Nina R Salama. Sustained infection accelerates gastric dysplasia in a mouse model. Life Sci Alliance; 2020 Dec 11;4(2):e202000967;doi: 10.26508/Isa.202000967. Print 2021 Feb. PMID: 33310760. PMCID: PMC7768197.
89 PMC7726005 Anne R Meyer, Amy C Engevik, Toni Madorsky, Erika Belmont, Matthew T Stier, Allison E Norlander, Mark A Pilkinton, Wyatt J McDonnell, Jared A Weis, Bogun Jang, Simon A Mallal, R Stokes Peebles, James R Goldenring (PC). Group 2 innate lymphoid cells coordinate damage response in the stomach. Gastroenterology 159(6):2077-2091.e8, 2020; PMC7726005.
90 PMC7878294 Aaron A May-Zhang, Eric Tycksen, Austin N Southard-Smith, Karen K Deal, Joseph T Benthal, Dennis P Buehler, Mike Adam, Alan J Simmons, James R Monaghan, Brittany K Matlock, David K Flaherty, S Steven Potter, Ken S Lau (PC), E Michelle Southard-Smith (PC). Combinatorial transcriptional profiling of mouse and human enteric neurons identifies shared and disparate subtypes in situ. Gastroenterology 2020; 160(3):755-770.e26. PMC7878294.
91 PMC7832655 Qin Zhang, Dennis K Jeppesen, James N Higginbotham, Jeffrey L Franklin (PC), James E Crowe (GI), Robert J Coffey (PC). Angiotensin-converting enzyme 2-containing small extracellular vesicles and exomeres bind the severe acute respiratory syndrome coronavirus 2 spike protein. Gastroenterology 2020; 160(3):958-961.e3. PMC7832655.
92 PMC7455120 Kathryn E Beckermann , Rachel Hongo, Xiang Ye , Kirsten Young, Katie Carbonell , Diana C Contreras Healey, Peter J Siska, Sierra Barone , Caroline E Roe, Christof C Smith, Benjamin G Vincent, Frank M Mason, Jonathan M Irish, W Kimryn Rathmell, Jeffrey C Rathmell. CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation. JCI Insight. 2020. 5(16):e138729.  PMCID: PMC7455120.
93 PMC7230007 Dulari Jayawardena, Sangeeta Tyagi, Ali Nazmi, Danyvid Olivares-Villagómez (GI), Pradeep K Dudeja. Ion transport basis of diarrhea in a mouse model of adoptive T cell transfer colitis. Dig Dis Sci 65(6):1700-1709, 2020; PMC7230007.
94 PMC7175606 Ali Nazmi, Michael J Greer, Kristen L Hoek, M Blanca Piazuelo (GI), Joern-Hendrik Weitkamp (GI), Danyvid Olivares-Villagómez (GI). Osteopontin and iCD8α cells promote intestinal intraepithelial lymphocyte homeostasis. J Immunol 204(7):1968-1981, 2020; PMC7175606.
95 PMC7382224 Amrendra Kumar, Timothy M Hill, Laura E Gordy, Naveenchandra Suryadevara, Lan Wu, Andrew I Flyak, Jelena S Bezbradica, Luc Van Kaer (GI), Sebastian Joyce. Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells. Proc Natl Acad Sci U S A 2020; 117(29):17156-17165. PMC7382224.
96 PMC7415927 Anna E Vilgelm, Kensey Bergdorf, Melissa Wolf, Vijaya Bharti, Rebecca Shattuck-Brandt, Ashlyn Blevins, Caroline Jones, Courtney Phifer, Mason Lee, Cindy Lowe, Rachel Hongo, Kelli Boyd, James Netterville, Sarah Rohde, Kamran Idrees, Joshua A Bauer, David Westover, Bradley Reinfeld, Naira Baregamian, Ann Richmond, W Kimryn Rathmell, Ethan Lee (PC), Oliver G McDonald (PC), Vivian L Weiss. Fine-needle aspiration-based patient-derived cancer organoids. iScience 23(8):101408, 2020; PMC7415927.
97 PMC7477426 Jun Hong, Fatma Abid, Sharon Phillips, Safia N Salaria, Frank L Revetta, Dunfa Peng, Mary K Washington (OMN), Wael El-Rifai (PC), Abbes Belkhiri (PC). Co-overexpression of AXL and c-ABL predicts a poor prognosis in esophageal adenocarcinoma and promotes cancer cell survival. J Cancer 11(20):5867-5879, 2020; PMC7477426.
98 PMC6903704 Chaofan Li, Bibo Zhu, Young Min Son, Zheng Wang, Li Jiang, Min Xiang, Zhenqing Ye, Kathryn E Beckermann, Yue Wu, James W Jenkins, Peter J Siska, Benjamin G Vincent, Y S Prakash, Tobias Peikert, Brian T Edelson, Reshma Taneja, Mark H Kaplan, Jeffrey C Rathmell (OMN), Haidong Dong, Taro Hitosugi, Jie Sun. The transcription factor Bhlhe40 programs mitochondrial regulation of resident CD8 T cell fitness and functionality. Immunity 51(3):491-507.e7, 2019; PMC6903704.
99 PMC6664447 Dennis K Jeppesen, Aidan M Fenix, Jeffrey L Franklin (PC), James N Higginbotham, Qin Zhang, Lisa J Zimmerman, Daniel C Liebler, Jie Ping, Qi Liu, Rachel Evans, William H Fissell, James G Patton, Leonard H Rome, Dylan T Burnette, Robert J Coffey (PC). Reassessment of exosome composition. Cell 177(2):428-445.e18, 2019; PMC6664447.
100 PMC6895174 Jimin Min, Paige N Vega, Amy C Engevik, Janice A Williams, Qing Yang, Loraine M Patterson, Alan J Simmons, R Jarrett Bliton, Joshua W Betts, Ken S Lau (PC), Scott T Magness, James R Goldenring (PC), Eunyoung Choi (PC). Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach. Nat Commun 10(1):5549, 2019; PMC6895174.
101 PMC6377304 Lori A Coburn (OMN), Kshipra Singh, Mohammad Asim, Daniel P Barry, Margaret M Allaman, Nicole T Al-Greene, Dana M Hardbower, Dina Polosukhina, Christopher S Williams (GI), Alberto G Delgado, M Blanca Piazuelo (GI), M Kay Washington (OMN), Alain P Gobert, Keith T Wilson (GI). Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis. Oncogene 38(7):1067-1079, 2019; PMC6377304.
102 PMC6282860 Cherie' R Scurrah, Alan J Simmons, Ken S Lau (PC). Single-cell mass cytometry of archived human epithelial tissue for decoding cancer signaling pathways. Methods Mol Biol 1884:215-229, 2019; PMC6282860.
103 PMC6325247 Damian Maseda, Joseph P Zackular, Bruno Trindade, Leslie Kirk, Jennifer Lising Roxas, Lisa M Rogers, Mary K Washington (OMN), Liping Du, Tatsuki Koyama, V K Viswanathan, Gayatri Vedantam, Patrick D Schloss, Leslie J Crofford, Eric P Skaar (GI), David M Aronoff (GI). Nonsteroidal anti-inflammatory drugs alter the microbiota and exacerbate Clostridium difficile colitis while dysregulating the inflammatory response. mBio 10(1), 2019; PMC6325247.
104 PMC6360258 Alex J Freemerman, Liyang Zhao, Ajeeth K Pingili, Bin Teng, Alyssa J Cozzo, Ashley M Fuller, Amy R Johnson, J Justin Milner, Maili F Lim, Joseph A Galanko, Melinda A Beck, James E Bear, Jeremy D Rotty, Lavanya Bezavada, Heather S Smallwood, Michelle A Puchowicz, Juan Liu, Jason W Locasale, Douglas P Lee, Brian J Bennett, E Dale Abel, Jeff C Rathmell (OMN), Liza Makowski. Myeloid -deficient murine model revealed macrophage activation and metabolic phenotype are fueled by GLUT1. J Immunol 202(4):1265-1286, 2019; PMC6360258.
105 PMC6486546 Shilpa Sampathi, Pankaj Acharya, Yue Zhao, Jing Wang, Kristy R Stengel, Qi Liu, Michael R Savona, Scott W Hiebert (GI). The CDK7 inhibitor THZ1 alters RNA polymerase dynamics at the 5' and 3' ends of genes. Nucleic Acids Res 47(8):3921-3936, 2019; PMC6486546.
106 PMC6448596 Erin R Aho, Jing Wang, Rocco D Gogliotti, Gregory C Howard, Jason Phan, Pankaj Acharya, Jonathan D Macdonald, Ken Cheng, Shelly L Lorey, Bin Lu, Sabine Wenzel, Audra M Foshage, Joseph Alvarado, Feng Wang, J Grace Shaw, Bin Zhao, April M Weissmiller, Lance R Thomas, Christopher R Vakoc, Matthew D Hall, Scott W Hiebert (GI), Qi Liu, Shaun R Stauffer, Stephen W Fesik, William P Tansey. Displacement of WDR5 from chromatin by a WIN site inhibitor with picomolar affinity. Cell Rep 26(11):2916-2928.e13, 2019; PMC6448596.
107 PMC6433850 Celestine N Wanjalla, Wyatt J McDonnell, Louise Barnett, Joshua D Simmons, Briana D Furch, Morgan C Lima, Beverly O Woodward, Run Fan, Ye Fei, Paxton G Baker, Ramesh Ram, Mark A Pilkinton, Mona Mashayekhi, Nancy J Brown, Simon A Mallal, Spyros A Kalams, John R Koethe (OMN). Adipose tissue in persons with HIV is enriched for CD4 T effector memory and T effector memory RA cells, which show higher CD69 expression and CD57, CX3CR1, GPR56 co-expression with increasing glucose intolerance. Front Immunol 10:408, 2019; PMC6433850.
108 PMC6497464 Linda V Sinclair, Andrew Jm Howden, Alejandro Brenes, Laura Spinelli, Jens L Hukelmann, Andrew N Macintyre, Xiaojing Liu, Sarah Thomson, Peter M Taylor, Jeffrey C Rathmell (OMN), Jason W Locasale, Angus I Lamond, Doreen A Cantrell. Antigen receptor control of methionine metabolism in T cells. Elife 8, 2019; PMC6497464.
109 PMC6892971 Hubaida Fuseini, Jacqueline-Yvonne Cephus, Pingsheng Wu, J Brooke Davis, Diana C Contreras, Vivek D Gandhi, Jeffrey C Rathmell (OMN), Dawn C Newcomb. ERα signaling increased IL-17A production in Th17 cells by upregulating IL-23R expression, mitochondrial respiration, and proliferation. Front Immunol 10:2740, 2019; PMC6892971.
110 PMC6476890 Peter A Kropp, Xiaodong Zhu, Maureen Gannon (PC). Regulation of the pancreatic exocrine differentiation program and morphogenesis by onecut 1/Hnf6. Cell Mol Gastroenterol Hepatol 2019; PMC6476890.
111 PMC6618044 Zheng Cao, Bhuminder Singh (PC), Cunxi Li, Nicholas O Markham (GI), Léolène J Carrington, Jeffrey L Franklin (PC), Ramona Graves-Deal, Eileen J Kennedy, James R Goldenring (PC), Robert J Coffey (PC). Protein kinase A-mediated phosphorylation of naked cuticle homolog 2 stimulates cell-surface delivery of transforming growth factor-α for epidermal growth factor receptor transactivation. Traffic 20(5):357-368, 2019; PMC6618044.
112 PMC6713894 Anne R Meyer, Amy C Engevik, Spencer G Willet, Janice A Williams, Yong Zou, Pierre P Massion, Jason C Mills, Eunyoung Choi (PC), James R Goldenring (PC). Cystine/glutamate antiporter (xCT) is required for chief cell plasticity after gastric injury. Cell Mol Gastroenterol Hepatol 8(3):379-405, 2019; PMC6713894.
113 PMC6613640 Carly R Cabel, Elaheh Alizadeh, David J Robbins, Yashi Ahmed, Ethan Lee (PC), Curtis A Thorne. Single-cell analyses confirm the critical role of LRP6 for Wnt signaling in APC-Deficient cells. Dev Cell 49(6):827-828, 2019; PMC6613640.
114 PMC6857048 Lina Sun, Ying Fang, Xin Wang, Yanan Han, Feng Du, Cunxi Li, Huaying Hu, Hao Liu, Qi Liu, Jing Wang, Junrong Liang, Ping Chen, Hongbin Yang, Yongzhan Nie, Kaichun Wu, Daiming Fan, Robert J Coffey (PC), Yuanyuan Lu, Xiaodi Zhao. miR-302a inhibits metastasis and cetuximab resistance in colorectal cancer by targeting NFIB and CD44. Theranostics 9(26):8409-8425, 2019; PMC6857048.
115 PMC7052570 Denitra A Breuer, Maria Cristina Pacheco, M Kay Washington (OMN), Stephanie A Montgomery, Alyssa H Hasty (OMN), Arion J Kennedy. CD8 T cells regulate liver injury in obesity-related nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol 2019; 318(2):G211-G224. PMC7052570.
116 PMC6279525 Amy C Engevik, Izumi Kaji, Melinda A Engevik, Anne R Meyer, Victoria G Weis, Anna Goldstein, Michael W Hess, Thomas Müller, Hermann Koepsell, Pradeep K Dudeja, Matthew Tyska (PC), Lukas A Huber, Mitchell D Shub, Nadia Ameen, James R Goldenring (PC). Loss of MYO5B leads to reductions in Na+ absorption with maintenance of CFTR-dependent Cl- secretion in enterocytes. Gastroenterology 155(6):1883-1897.e10, 2018; PMC6279525.
117 PMC5748848 Matthew T Stier, Jian Zhang, Kasia Goleniewska, Jacqueline Y Cephus, Mark Rusznak, Lan Wu, Luc Van Kaer (GI), Baohua Zhou, Dawn C Newcomb, R Stokes Peebles. IL-33 promotes the egress of Group 2 innate lymphoid cells from the bone marrow. J Exp Med 215(1):263-281, 2018; PMC5748848.
118 PMC5806629 Yen-Hua Chen, Radomir Kratchmarov, Wen-Hsuan W Lin, Nyanza J Rothman, Bonnie Yen, William C Adams, Simone A Nish, Jeffrey C Rathmell (OMN), Steven L Reiner. Asymmetric PI3K activity in lymphocytes organized by a PI3K-mediated polarity pathway. Cell Rep 22(4):860-868, 2018; PMC5806629.
119 PMC6138561 Andela Horvat, Jennifer M Noto, Balamurugan Ramatchandirin, Elena Zaika, Manikandan Palrasu, Jinxiong Wei, Barbara G Schneider (GI), Wael El-Rifai (PC), Richard M Peek (GI), Alexander I Zaika (GI). Helicobacter pylori pathogen regulates p14ARF tumor suppressor and autophagy in gastric epithelial cells. Oncogene 37(37):5054-5065, 2018; PMC6138561.
120 PMC6176072 Sung Won Lee, Hyun Jung Park, Jae Hee Cheon, Lan Wu, Luc Van Kaer (GI), Seokmann Hong. iNKT cells suppress pathogenic NK1.1+CD8+ T cells in DSS-induced colitis. Front Immunol 9:2168, 2018; PMC6176072.
121 PMC6248336 Scott A Hinger, Diana J Cha, Jeffrey L Franklin (PC), James N Higginbotham, Yongchao Dou, Jie Ping, Lihua Shu, Nripesh Prasad, Shawn Levy, Bing Zhang, Qi Liu, Alissa M Weaver, Robert J Coffey (PC), James G Patton. Diverse long RNAs are differentially sorted into extracellular vesicles secreted by colorectal cancer cells. Cell Rep 25(3):715-725.e4, 2018; PMC6248336.
122 PMC6275285 Jun Hong, Selma Maacha, Abbes Belkhiri (PC). Transcriptional upregulation of c-MYC by AXL confers epirubicin resistance in esophageal adenocarcinoma. Mol Oncol 12(12):2191-2208, 2018; PMC6275285.
123 PMC5681443 Christine P Petersen, Anne R Meyer, Carlo De Salvo, Eunyoung Choi (PC), Cameron Schlegel, Alec Petersen, Amy C Engevik, Nripesh Prasad, Shawn E Levy, R Stokes Peebles, Theresa T Pizarro, James R Goldenring (PC). A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach. Gut 67(5):805-817, 2018; PMC5681443.
124 PMC5671361 Johanna C Sierra, Mohammad Asim, Thomas G Verriere, M Blanca Piazuelo (GI), Giovanni Suarez, Judith Romero-Gallo, Alberto G Delgado, Lydia E Wroblewski, Daniel P Barry, Richard M Peek (GI), Alain P Gobert, Keith T Wilson (GI). Epidermal growth factor receptor inhibition downregulates Helicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis. Gut 67(7):1247-1260, 2018; PMC5671361.
125 PMC5815959 Eunyoung Choi (PC), Tyler L Lantz, Gregory Vlacich, Theresa M Keeley, Linda C Samuelson, Robert J Coffey (PC), James R Goldenring (PC), Anne E Powell. Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach. Gut 67(9):1595-1605, 2018; PMC5815959.
126 PMC5803339 Michael L Schulte, Allie Fu, Ping Zhao, Jun Li, Ling Geng, Shannon T Smith, Jumpei Kondo, Robert J Coffey (PC), Marc O Johnson, Jeffrey C Rathmell (OMN), Joe T Sharick, Melissa C Skala, Jarrod A Smith, Jordan Berlin (PC), M Kay Washington (OMN), Michael L Nickels, H Charles Manning (PC). Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat Med 24(2):194-202, 2018; PMC5803339.
127 PMC5884143 Kenyi Saito-Diaz, Hassina Benchabane, Ajit Tiwari, Ai Tian, Bin Li, Joshua J Thompson, Annastasia S Hyde, Leah M Sawyer, Jeanne N Jodoin, Eduardo Santos, Laura A Lee, Robert J Coffey (PC), R Daniel Beauchamp (PC), Christopher S Williams (GI), Anne K Kenworthy, David J Robbins, Yashi Ahmed, Ethan Lee (PC). APC inhibits ligand-independent Wnt signaling by the clathrin endocytic pathway. Dev Cell 44(5):566-581.e8, 2018; PMC5884143.
128 PMC6072585 Kshipra Singh, Lori A Coburn (OMN), Mohammad Asim, Daniel P Barry, Margaret M Allaman, Chanjuan Shi (OMN), M Kay Washington (OMN), Paula B Luis, Claus Schneider (GI), Alberto G Delgado, M Blanca Piazuelo (GI), John L Cleveland, Alain P Gobert, Keith T Wilson (GI). Ornithine decarboxylase in macrophages exacerbates colitis and promotes colitis-associated colon carcinogenesis by impairing M1 immune responses. Cancer Res 78(15):4303-4315, 2018; PMC6072585.
129 PMC6162144 Xi Shen, Liping Liu, Richard M Peek (GI), Sari A Acra (OMN), Daniel J Moore (OMN), Keith T Wilson (GI), Fang He, D Brent Polk, Fang Yan (GI). Supplementation of p40, a Lactobacillus rhamnosus GG-derived protein, in early life promotes epidermal growth factor receptor-dependent intestinal development and long-term health outcomes. Mucosal Immunol 11(5):1316-1328, 2018; PMC6162144.
130 PMC6198339 Wyatt J McDonnell, John R Koethe (OMN), Simon A Mallal, Mark A Pilkinton, Annet Kirabo, Magdalene K Ameka, Matthew A Cottam, Alyssa H Hasty (OMN), Arion J Kennedy. High CD8 T-cell receptor clonality and altered CDR3 properties are associated with elevated isolevuglandins in adipose tissue during diet-induced obesity. Diabetes 67(11):2361-2376, 2018; PMC6198339.
131 PMC6334257 Sungsook Yu, Mijeong Yang, Kyung-Min Lim, Yejin Cho, Hyunji Kim, Keunwook Lee, Sang-Ho Jeong, Robert J Coffey (PC), James R Goldenring (PC), Ki Taek Nam. Expression of LRIG1, a negative regulator of EGFR, is dynamically altered during different stages of gastric carcinogenesis. Am J Pathol 188(12):2912-2923, 2018; PMC6334257.
132  PMC5621889 Elizabeth M McDonough, Caitlyn W Barrett, Bobak Parang, Mukul K Mittal, J Joshua Smith, Amber M Bradley, Yash A Choksi (GI), Lori A Coburn (OMN), Sarah P Short (GI), Joshua J Thompson, Baolin Zhang, Shenika V Poindexter, Melissa A Fischer, Xi Chen, Jiang Li, Frank L Revetta, Rishi Naik, M Kay Washington (OMN), Michael J Rosen, Scott W Hiebert (GI), Keith T Wilson (GI), Christopher S Williams (GI). MTG16 is a tumor suppressor in colitis-associated carcinoma. JCI Insight 2(16), 2017; PMC5621889.
133 PMC5385850 Bobak Parang, Andrew M Kaz, Caitlyn W Barrett, Sarah P Short (GI), Wei Ning, Cody E Keating, Mukul K Mittal, Rishi D Naik, Mary K Washington (OMN), Frank L Revetta, J Joshua Smith, Xi Chen, Keith T Wilson (GI), Thomas Brand, David M Bader, William P Tansey, Ru Chen, Teresa A Brentnall, William M Grady, Christopher S Williams (GI). BVES regulates c-MYC stability via PP2A and suppresses colitis-induced tumourigenesis. Gut 66(5):852-862, 2017; PMC5385850.
134 PMC5517093 Yu-Ping Yang, Haiting Ma, Alina Starchenko, Won Jae Huh (PC), Wei Li, F Edward Hickman, Qin Zhang, Jeffrey L Franklin (PC), Douglas P Mortlock, Sabine Fuhrmann, Bruce D Carter, Rebecca A Ihrie, Robert J Coffey (PC). A chimeric EGFR protein reporter mouse reveals EGFR localization and trafficking in vivo. Cell Rep 19(6):1257-1267, 2017; PMC5517093.
135 PMC5961502 Yuanyuan Lu, Xiaodi Zhao, Qi Liu, Cunxi Li, Ramona Graves-Deal, Zheng Cao, Bhuminder Singh (PC), Jeffrey L Franklin (PC), Jing Wang, Huaying Hu, Tianying Wei, Mingli Yang, Timothy J Yeatman, Ethan Lee (PC), Kenyi Saito-Diaz, Scott Hinger, James G Patton, Christine H Chung, Stephan Emmrich, Jan-Henning Klusmann, Daiming Fan, Robert J Coffey (PC). lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling. Nat Med 23(11):1331-1341, 2017; PMC5961502.
136 PMC5707165 Sarah P Short (GI), Jumpei Kondo, Whitney G Smalley-Freed, Haruna Takeda, Michael R Dohn, Anne E Powell, Robert H Carnahan, Mary K Washington (OMN), Manish Tripathi, D Michael Payne, Nancy A Jenkins, Neal G Copeland, Robert J Coffey (PC), Albert B Reynolds (PC). p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia. J Clin Invest 127(12):4462-4476, 2017; PMC5707165.
137 PMC5418141 Aaram A Kumar, Alberto G Delgado, M Blanca Piazuelo (GI), Luc Van Kaer (GI), Danyvid Olivares-Villagómez (GI). Innate CD8αα lymphocytes enhance anti-CD40 antibody-mediated colitis in mice. Immun Inflamm Dis 5(2):109-123, 2017; PMC5418141.
138 PMC5595071 Mohammed Soutto, Mohamed Saleh, Mohamed S Arredouani, Blanca Piazuelo (GI), Abbes Belkhiri (PC), Wael El-Rifai (PC). Loss of TFF1 promotes pro-Inflammatory phenotype with increase in the levels of RORγt+ T lymphocytes and IL-17 in mouse gastric neoplasia. J Cancer 8(13):2424-2435, 2017; PMC5595071.
139 PMC5581681 Michael W Pickup, Philip Owens, Agnieszka E Gorska, Anna Chytil, Fei Ye, Chanjuan Shi (OMN), Valerie M Weaver, Raghu Kalluri, Harold L Moses, Sergey V Novitskiy. Development of aggressive pancreatic ductal adenocarcinomas depends on granulocyte colony stimulating factor secretion in carcinoma cells. Cancer Immunol Res 5(9):718-729, 2017; PMC5581681.
140 PMC5659751 Poojitha Matta, Stacy D Sherrod, Christina C Marasco, Daniel J Moore (OMN), John A McLean, Joern-Hendrik Weitkamp (GI). In utero exposure to histological chorioamnionitis primes the exometabolomic profiles of preterm CD4 T lymphocytes. J Immunol 199(9):3074-3085, 2017; PMC5659751.
141 PMC5630609 Yue Ren, Etsuko Sekine-Kondo, Risa Shibata, Megumi Kato-Itoh, Ayumi Umino, Ayaka Yanagida, Masashi Satoh, Komaki Inoue, Tomoyuki Yamaguchi, Keiichi Mochida, Susumu Nakae, Luc Van Kaer (GI), Kazuya Iwabuchi, Hiromitsu Nakauchi, Hiroshi Watarai. A novel mouse model of iNKT cell-deficiency generated by CRISPR/Cas9 reveals a pathogenic role of iNKT cells in metabolic disease. Sci Rep 7(1):12765, 2017; PMC5630609.
142 PMC5762435 John R Koethe (OMN), Wyatt McDonnell, Arion Kennedy, Chike O Abana, Mark Pilkinton, Ian Setliff, Ivelin Georgiev, Louise Barnett, Cindy C Hager, Rita Smith, Spyros A Kalams, Alyssa Hasty (OMN), Simon Mallal. Adipose tissue is enriched for activated and late-differentiated CD8+ T cells, and shows distinct CD8+ receptor usage, compared to blood in HIV-infected persons. J Acquir Immune Defic Syndr 2017; 77(2):e14-e21. PMC5762435.
143 PMC5688132 Amrendra Kumar, Laura E Gordy, Jelena S Bezbradica, Aleksandar K Stanic, Timothy M Hill, Mark R Boothby, Luc Van Kaer (GI), Sebastian Joyce. NF-κB protects NKT cells from tumor necrosis factor receptor 1-induced death. Sci Rep 7(1):15594, 2017; PMC5688132.
144 PMC5250617 Susana Beceiro, Jana N Radin, Rupesh Chatuvedi, M Blanca Piazuelo (GI), David J Horvarth, Hanna Cortado, Yuqing Gu, Beverly Dixon, Chendi Gu, Ingo Lange, Dana-Lynn T Koomoa, Keith T Wilson (GI), Holly M S Algood (GI), Santiago Partida-Sánchez. TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection. Mucosal Immunol 10(2):493-507, 2017; PMC5250617.
145 PMC5256201 Andrew O'Neil, Christine P Petersen, Eunyoung Choi (PC), Amy C Engevik, James R Goldenring (PC). Unique cellular lineage composition of the first gland of the mouse gastric corpus. J Histochem Cytochem 65(1):47-58, 2017; PMC5256201.
146 PMC5589585 Zheng Chen, Tianling Hu, Shoumin Zhu, Kenichi Mukaisho, Wael El-Rifai (PC), Dun-Fa Peng. Glutathione peroxidase 7 suppresses cancer cell growth and is hypermethylated in gastric cancer. Oncotarget 8(33):54345-54356, 2017; PMC5589585.
147 PMC5555225 Bin Li, Darren Orton, Leif R Neitzel, Luisana Astudillo, Chen Shen, Jun Long, Xi Chen, Kellye C Kirkbride, Thomas Doundoulakis, Marcy L Guerra, Julia Zaias, Dennis Liang Fei, Jezabel Rodriguez-Blanco, Curtis Thorne, Zhiqiang Wang, Ke Jin, Dao M Nguyen, Laurence R Sands, Floriano Marchetti, Maria T Abreu, Melanie H Cobb, Anthony J Capobianco, Ethan Lee (PC), David J Robbins. Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors. Sci Signal 10(485), 2017; PMC5555225.
148 PMC5547642 Vrajesh V Parekh, Sudheer K Pabbisetty, Lan Wu, Eric Sebzda, Jennifer Martinez, Jianhua Zhang, Luc Van Kaer (GI). Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α dendritic cells. Proc Natl Acad Sci U S A 114(31):E6371-E6380, 2017; PMC5547642.
149 PMC5577233 Vikas Bhardwaj, Ravindran Caspa Gokulan, Andela Horvat, Liudmila Yermalitskaya, Olga Korolkova, Kay M Washington (OMN), Wael El-Rifai (PC), Sergey I Dikalov, Alexander I Zaika (GI). Activation of NADPH oxidases leads to DNA damage in esophageal cells. Sci Rep 7(1):9956, 2017; PMC5577233.
150 PMC5675767 Bowen Li, Weizhi Wang, Zheng Li, Zheng Chen, Xiaofei Zhi, Jianghao Xu, Qing Li, Lu Wang, Xiaoxu Huang, Linjun Wang, Song Wei, Guangli Sun, Xuan Zhang, Zhongyuan He, Lu Zhang, Diancai Zhang, Hao Xu, Wael El-Rifai (PC), Zekuan Xu. MicroRNA-148a-3p enhances cisplatin cytotoxicity in gastric cancer through mitochondrial fission induction and cyto-protective autophagy suppression. Cancer Lett 410:212-227, 2017; PMC5675767.
151 PMC5733579 Elena Kolobova, Joseph T Roland, Lynne A Lapierre, Janice A Williams, Twila A Mason, James R Goldenring (PC). The C-terminal region of A-kinase anchor protein 350 (AKAP350A) enables formation of microtubule-nucleation centers and interacts with pericentriolar proteins. J Biol Chem 292(50):20394-20409, 2017; PMC5733579.
152 PMC7866066 Hyun Jung Park, Sung Won Lee, Luc Van Kaer (GI), Seokmann Hong. CD1d-dependent iNKT cells control DSS-induced colitis in a mouse model of IFNg-mediated hyperinflammation by increasing IL22-secreting ILC3 cells. Int J Mol Sci; 2021 Jan 27;22(3):1250. doi: 10.3390/ijms22031250. PMID: 33513946; PMCID: PMC7866066.
153 PMC5715752 Allegra T Aron, Marie C Heffern, Zachery R Lonergan, Mark N Vander Wal, Brian R Blank, Benjamin Spangler, Yaofang Zhang, Hyo Min Park, Andreas Stahl, Adam R Renslo, Eric P Skaar (GI), Christopher J Chang. In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection. Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12669-12674. doi: 10.1073/pnas.1708747114. Epub 2017 Nov 14. PMID: 29138321; PMCID: PMC5715752.
154 PMC5985044 W Reid Bolus, Kristin R Peterson, Merla J Hubler, Arion J Kennedy, Marnie L Gruen, Alyssa H Hasty (OMN). Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments. Mol Metab. 2018 Feb;8:86-95. doi: 10.1016/j.molmet.2017.12.004. Epub 2017 Dec 16. PMID: 29306658; PMCID: PMC5985044.
155 PMC8090962 Nicholas O Markham (GI), Sarah C Bloch, John A Shupe, Erin N Laubacher, Audrey K Thomas, Heather K Kroh, Kevin O Childress, F Christopher Peritore-Galve, M Kay Washington (OMN), Robert J Coffey (PC), D Borden Lacy (GI). Murine intrarectal instillation of purified recombinant toxins enables mechanistic studies of pathogenesis. Infect Immun 2021; 89(4):e00543-20. PMC8090962.
156 PMC8091839 Anthony Mannion, JoAnn Dzink-Fox, Zeli Shen, M Blanca Piazuelo (GI), Keith T Wilson (GI), Pelayo Correa, Richard M Peek (GI), M Constanza Camargo, James G Fox. Helicobacter pylori antimicrobial resistance and gene variants in high- and low-gastric-cancer-risk populations. J Clin Microbiol. 2021 Apr 20:59(5):e03203-20. Print 2021 Apr 20. PMID: 33692136. PMCID: PMC8091839.
157  PMC7945590 Rajeev K Tyagi, Justin Jacobse, Jing Li, Margret M Allaman, Kevin L Otipoby, Erik R Sampson, Keith T Wilson (GI), Jeremy A Goettel (PC). HLA-restriction of human Treg cells is not required for therapeutic Efficacy of low-dose IL-2 in humanized mice. Front Immunol. 2021 Feb 24;12:630204,doi: 10.3389/fimmu.2021.630204.eCollection 2021. PMID: 33717161. PMCID: PMC7945590
158 PMC7190987 Manikandan Palrasu, Elena Zaika, Wael El-Rifai, Monica Garcia-Buitrago, Maria Blanca Piazuelo (GI), Keith T Wilson (GI), Richard M Peek (GI), Alexander I Zaika. Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells. 130(5):2422-2434. J Clin Invest 2020; 130(5):2422-2434. PMC7190987.
159 PMC7486240 Reece J Knippel, Aaron G Wexler, Jeanette M Miller, William N Beavers, Andy Weiss, Valérie de Crécy-Lagard, Katherine A Edmonds, David P Giedroc, Eric P Skaar (GI). Clostridioides difficile senses and hijacks host heme for incorporation into an oxidative stress defense system. Cell Host Microbe 2020; PMC7486240.
160 PMC7327173 Aung Soe Lin, Mark S McClain (GI), Amber C Beckett, Rhonda R Caston, M Lorena Harvey, Beverly R E A Dixon, Anne M Campbell, Jennifer H B Shuman, Neha Sawhney, Alberto G Delgado, John T Loh (GI), M Blanca Piazuelo (GI), Holly M Scott Algood (GI), Timothy L Cover (GI). Temporal control of the Helicobacter pylori Cag type IV secretion system in a Mongolian gerbil model of gastric carcinogenesis. mBio 11(3), 2020; PMC7327173.
161 PMC7956231 M Blanca Piazuelo (GI), Luis E Bravo, Robertino M Mera, M Constanza Camargo, Juan C Bravo, Alberto G Delgado, M Kay Washington (OMN), Alicia Rosero, Luz S Garcia, Jose L Realpe, Sandra P Cifuentes, Douglas R Morgan (GI), Richard M Peek (GI), Pelayo Correa, Keith T Wilson (GI). The Colombian chemoprevention trial: Twenty-year follow-up of a cohort of patients with gastric precancerous lesions. Gastroenterology 2020; 160(4):1106-1117.e3. PMC7956231.
162 PMC8035252 Sarah P Short (GI), Jennifer M Pilat, Caitlyn W Barrett, Vishruth K Reddy, Yael Haberman, Jared R Hendren, Benjamin J Marsh, Cody E Keating, Amy K Motley, Kristina E Hill, Anne E Zemper, M Kay Washington (OMN), Chanjuan Shi, Xi Chen, Keith T Wilson (GI), Jeffrey S Hyams, Lee A Denson, Raymond F Burk, Michael J Rosen, Christopher S Williams (GI). Colonic epithelial-derived Selenoprotein P is the source for antioxidant-mediated protection in colitis-associated cancer. Gastroenterology 2020; 160(5):1694-1708. PMC8035252.
163 PMC6925320 David M Anderson, Michael J Sheedlo, Jaime L Jensen, D Borden Lacy (GI). Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore. Nat Microbiol 5(1):102-107, 2020; PMC6925320.
164 PMC7023271 Alejandra Ribera-Fonseca, Danae Jiménez, Pamela Leal, Ismael Riquelme, Juan Carlos Roa, Miren Alberdi, Richard M Peek (GI), Marjorie Reyes-Díaz. The anti-proliferative and anti-Invasive effect of leaf extracts of blueberry plants treated with methyl jasmonate on human gastric cancer in vitro is related to their antioxidant properties. Antioxidants (Basel) 9(1), 2020; PMC7023271.
165 PMC7230009 Melissa A Farrow, Nicole M Chumber, Sarah C Bloch, McKenzie King, Kaycei Moton-Melancon, John Shupe, Mary K Washington (OMN), Benjamin W Spiller (GI), D Borden Lacy (GI). Small molecule inhibitor screen reveals calcium channel signaling as a mechanistic mediator of TcdB-Induced necrosis. ACS Chem Biol 2020; 15(5):1212-1221. PMC7230009.
166 PMC7230019 Andrew T Hale, Rachel E Brown, Zigmund Luka, Benjamin H Hudson, Pranathi Matta, Christopher S Williams (GI), John D York. Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice. Adv Biol Regul :100694, 2020; PMC7230019.
167 PMC7979265 Babak Banan, Jacob A Beckstead, Lauren E Dunavant, Yoojin Sohn, Jamie M Adcock, Sachiyo Nomura, Naji Abumrad (OMN), James R Goldenring (PC), Barbara Fingleton (PC). Development of a novel murine model of lymphatic metastasis. Clin Exp Metastasis 37(2):247-255, 2020; PMC7979265.
168 PMC7193953 Clinton M Hasenour, Arion J Kennedy, Tomasz Bednarski, Irina A Trenary, Brandon J Eudy, Robin P DaSilva, Kelli L Boyd, Jamey D Young (OMN). Vitamin E does not prevent Western diet-induced NASH progression and increases metabolic flux dysregulation in mice.  J Lipid Res 2020; 61(5):707-721. PMC7193953.
169 PMC7474156 Elizabeth H Manning, Lynne A Lapierre, Jason C Mills, James R Goldenring (PC). Tamoxifen acts as a parietal cell protonophore. Cell Mol Gastroenterol Hepatol 10(3):655-657.e1, 2020; PMC7474156.
170 PMC7755565 Mark T Whary, Jose M Restrepo Avenia, Luis E Bravo, Jennifer L Lofgren, Kvin Lertpiriyapong, Robertino Mera-Giler, M Blanca Piazuelo (GI), Pelayo Correa, Richard M Peek (GI), Keith T Wilson (GI), James G Fox. Contrasting serum biomarker profiles in two Colombian populations with different risks for progression of premalignant gastric lesions during chronic Helicobacter pylori infection. Cancer Epidemiol 67:101726, 2020; PMC7755565.
171 NIHMS1647896 Andreana N Holowatyj, Kay M Washington (OMN), Safia N Salaria, Christopher H Lieu, Kamran Idrees, Cathy Eng, Paulette D Chandler, Heather Hampel, Richard L Martin, Mark A Lewis. Early-onset appendiceal cancer survival by race or ethnicity in the United States. Gastroenterology 2020; 159(4):1605-1608. NIHMS1647896.
172 PMC7459361 Douglas K Brubaker, Manu P Kumar, Evan L Chiswick, Cecil Gregg, Alina Starchenko, Paige N Vega, Austin N Southard-Smith, Alan J Simmons, Elizabeth A Scoville (OMN), Lori A Coburn (OMN), Keith T Wilson (GI), Ken S Lau (PC), Douglas A Lauffenburger. An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease. Sci Signal 13(643), 2020; PMC7459361.
173 PMC7818496 Brian T Palmisano, Uche Anozie, Sophia Yu, Joshua C Neuman, Lin Zhu, Emery M Edington, Thao Luu, John M Stafford (OMN). Cholesteryl ester transfer protein impairs triglyceride clearance via androgen receptor in male mice. Lipids 2020; 56(1):17-29. PMC7818496.
174 PMC7755675 Carlo De Salvo, Luca Pastorelli, Christine P Petersen, Ludovica F Buttò, Kristine-Ann Buela, Sara Omenetti, Silviu A Locovei, Shuvra Ray, Hannah R Friedman, Jacob Duijser, Wei Xin, Abdullah Osme, Fabio Cominelli, Ganapati H Mahabeleshwar, Jason C Mills, James R Goldenring (PC), Theresa T Pizarro. Interleukin 33 triggers early eosinophil-dependent events leading to metaplasia in a chronic model of gastritis-prone mice. Gastroenterology 2020; 160(1):302-316.e7. PMC7755675.
175 PMC7682618 Cambrian Y Liu, Sharon S Tam, Ying Huang, Philip E Dubé, Rabea Alhosh, Nandini Girish, Shivesh Punit, Shirin Nataneli, Fan Li, Jeffrey M Bender, M Kay Washington (OMN), D Brent Polk. TNF receptor 1 promotes early-life immunity and protects against colitis in mice. Cell Rep 33(3):108275, 2020; PMC7682618.
176 PMC7856291 Meredith A Jackson, Shrusti S Patel, Fang Yu, Matthew A Cottam, Evan B Glass, Ella N Hoogenboezem, R Brock Fletcher, Bryan R Dollinger, Prarthana Patil, Danielle D Liu, Isom B Kelly, Sean K Bedingfield, Allyson R King, Rachel E Miles, Alyssa M Hasty (OMN), Todd D Giorgio, Craig L Duvall. Kupffer cell release of platelet activating factor drives dose limiting toxicities of nucleic acid nanocarriers. Biomaterials 268:120528, 2020; PMC7856291.
177 PMID:33245103 Samuel D R Dooyema, Uma S Krishna, John T Loh (GI), Giovanni Suarez, Timothy L Cover (GI), Richard M Peek (GI). Helicobacter pylori-induced TLR9 activation and injury are associated with the virulence-associated adhesin HopQ. J Infect Dis 2020; jiaa730. PMID:33245103.
178 PMC7946809 Babak Banan, Yan Wei, Ornella Simo, Patrick Tso, Naji N Abumrad (OMN), Charles Robb Flynn (OMN), Sinju Sundaresan, Vance L Albaugh. Intestinal lymph collection via cannulation of the mesenteric lymphatic duct in mice. J Surg Res 2020; 260:399-408. PMC7946809.
179 PMC7812972 Alain P Gobert, Jordan L Finley, Yvonne L Latour, Mohammad Asim, Thaddeus M Smith, Thomas G Verriere, Daniel P Barry, Margaret M Allaman, Alberto G Delagado, Kristie L Rose, M Wade Calcutt, Kevin L Schey (PC), Johanna C Sierra, M Blanca Piazuelo (GI), Raghavendra G Mirmira, Keith T Wilson (GI). Hypusination orchestrates the antimicrobial response of macrophages. Cell Rep 33(11):108510, 2020; PMC7812972.
180 PMC7802691 Jumpei Kondo, Won Jae Huh (PC), Jeffrey L Franklin (PC), Michael C Heinrich, Brian P Rubin, Robert J Coffey (PC). A smooth muscle-derived, BRAF-driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell-of-origin. J Pathol 2020; 252(4):441-450. PMC7802691.
181 PMC6409186 Vance L Albaugh, Babak Banan, Joseph Antoun, Yanhua Xiong, Yan Guo, Jie Ping, Muhammed Alikhan, Blake Austin Clements, Naji N Abumrad (OMN), Charles Robb Flynn (OMN). Role of bile acids and GLP-1 in mediating the metabolic improvements of bariatric surgery. Gastroenterology 156(4):1041-1051.e4, 2019; PMC6409186.
182 PMC6629246 Jane F Ferguson (OMN), Luul A Aden, Natalia R Barbaro, Justin P Van Beusecum, Liang Xiao, Alan J Simons, Cassandra Warden, Lejla Pasic, Lauren E Himmel, Mary K Washington (OMN), Frank L Revetta, Shilin Zhao, Shivani Kumaresan, Matthew B Scholz, Zhengzheng Tang, Guanhua Chen, Muredach P Reilly, Annet Kirabo. High dietary salt-induced dendritic cell activation underlies microbial dysbiosis-associated hypertension. JCI Insight 5, 2019; PMC6629246.
183 PMC6445772 Giovanni Suarez, Judith Romero-Gallo, Maria B Piazuelo (GI), Johanna C Sierra, Alberto G Delgado, M Kay Washington (OMN), Shailja C Shah (PC), Keith T Wilson (GI), Richard M Peek (GI). NOD1 imprints inflammatory and carcinogenic responses toward the gastric pathogen Helicobacter pylori. Cancer Res 79(7):1600-1611, 2019; PMC6445772.
184 PMC6355059 Linlin Shao, Zheng Chen, Mohammed Soutto, Shoumin Zhu, Heng Lu, Judith Romero-Gallo, Richard Peek (GI), Shutian Zhang, Wael El-Rifai (PC). Helicobacter pylori-induced miR-135b-5p promotes cisplatin resistance in gastric cancer. FASEB J 33(1):264-274, 2019; PMC6355059.
185 PMC6410348 Ravindran Caspa Gokulan, Jamie M Adcock, Irene Zagol-Ikapitte, Raymond Mernaugh, Phillip Williams, Kay M Washington (OMN), Olivier Boutaud, John A Oates, Sergey I Dikalov, Alexander I Zaika (GI). Gastroesophageal reflux induces protein adducts in the esophagus. Cell Mol Gastroenterol Hepatol 7(2):480-482.e7, 2019; PMC6410348.
186 PMC6450535 Raul S Gonzalez, Justin M M Cates, Kay Washington (OMN). Associations among histological characteristics and patient outcomes in colorectal carcinoma with a mucinous component. Histopathology 74(3):406-414, 2019; PMC6450535.
187 PMC6409191 Zheng Chen, Zheng Li, Mohammed Soutto, Weizhi Wang, M Blanca Piazuelo (GI), Shoumin Zhu, Yan Guo, Maria J Maturana, Alejandro H Corvalan, Xi Chen, Zekuan Xu, Wael M El-Rifai (PC). Integrated analysis of mouse and human gastric neoplasms identifies conserved microRNA networks in gastric carcinogenesis. Gastroenterology 156(4):1127-1139.e8, 2019; PMC6409191.
188 PMC6327977 Jing Liu, Amrita Banerjee, Charles A Herring, Jonathan Attalla, Ruiying Hu, Yanwen Xu, Qiujia Shao, Alan J Simmons, Prasanna K Dadi, Sui Wang, David A Jacobson, Bindong Liu, Emily Hodges, Ken S Lau (PC), Guoqiang Gu. Neurog3-independent methylation is the earliest detectable mark distinguishing pancreatic progenitor identity. Dev Cell 48(1):49-63.e7, 2019; PMC6327977.
189 PMC6344515 Linda S May-Zhang, Zhongyi Chen, Noura S Dosoky, Patricia G Yancey, Kelli L Boyd, Alyssa H Hasty (OMN), MacRae F Linton, Sean S Davies (OMN). Administration of N-acyl-phosphatidylethanolamine expressing bacteria to low density lipoprotein receptor mice improves indices of cardiometabolic disease. Sci Rep 9(1):420, 2019; PMC6344515.
190 PMC6417938 Martha Frances Wright, Justin Cates, Raul S Gonzalez, Satya Das, Jordan D Berlin (PC), Chanjuan Shi (OMN). Impact of peritoneal metastasis on survival of patients with small intestinal neuroendocrine tumor. Am J Surg Pathol 43(4):559-563, 2019; PMC6417938.
191 PMC6405515 Kalyan C Vinnakota, Venkat R Pannala, Martha L Wall, Mohsin Rahim, Shanea K Estes, Irina Trenary, Tracy P O'Brien, Richard L Printz, Jaques Reifman, Masakazu Shiota (OMN), Jamey D Young (OMN), Anders Wallqvist. Network modeling of liver metabolism to predict plasma metabolite changes during short-term fasting in the laboratory rat. Front Physiol 10:161, 2019; PMC6405515.
192 PMC6732653 Elijah Trefts, Curtis C Hughey, Louise Lantier, Dan S Lark, Kelli L Boyd, Ambra Pozzi, Roy Zent, David H Wasserman (OMN). Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner. Am J Physiol Endocrinol Metab 316(6):E1118-E1135, 2019; PMC6732653.
193 PMC6426600 Aleksandra Altobelli, Michael Bauer, Karelia Velez, Timothy L Cover (GI), Anne Müller. VacA targets myeloid cells in the gastric lamina propria to promote peripherally induced regulatory T-cell differentiation and persistent infection. mBio 10(2), 2019; PMC6426600.
194 PMC6613866 Girish Hiremath, Meghan H Shilts, Helen H Boone, Hernan Correa, Sari Acra (OMN), Andrey Tovchigrechko, Seesandra V Rajagopala, Suman R Das. The salivary microbiome is altered in children with eosinophilic esophagitis and correlates with disease activity. Clin Transl Gastroenterol 2019; 10(6):e00039. PMC6613866.
195 PMC6619433 Vivian Ortiz, Dagoberto Estevez-Ordonez, Eleazar Montalvan-Sanchez, Samuel Urrutia-Argueta, Dawn Israel (GI), Uma S Krishna, Judith Romero-Gallo, Keith T Wilson (GI), Richard M Peek (GI), Ricardo Dominguez, Douglas R Morgan (GI). Helicobacter pylori antimicrobial resistance and antibiotic consumption in the low-resource Central America setting. Helicobacter 24(4):e12595, 2019; PMC6619433.
196 PMC6538789 Jennifer M Noto, Joseph P Zackular, Matthew G Varga, Alberto Delgado, Judith Romero-Gallo, Matthew B Scholz, M Blanca Piazuelo (GI), Eric P Skaar (GI), Richard M Peek (GI). Modification of the gastric mucosal microbiota by a strain-specific Helicobacter pylori oncoprotein and carcinogenic histologic phenotype. mBio 10(3), 2019; PMC6538789.
197 PMC6541464 Shigao Yang, Alfred T Harding, Catherine Sweeney, David Miao, Gregory Swan, Connie Zhou, Zhaozhao Jiang, Katherine A Fitzgerald, Gianna Hammer, Martin O Bergo, Heather K Kroh, D Borden Lacy (GI), Chunxiang Sun, Michael Glogauer, Loretta G Que, Nicholas S Heaton, Donghai Wang. Control of antiviral innate immune response by protein geranylgeranylation. Sci Adv 5(5):eaav7999, 2019; PMC6541464.
198 PMC6669412 Jordan Roberts, Safia N Salaria, Justin Cates, Yang Wang, Cindy Vnencak-Jones, Jordan Berlin (PC), Chanjuan Shi (OMN). PD-L1 expression patterns in microsatellite instability-high intestinal adenocarcinoma subtypes. Am J Clin Pathol 152(3):384-391, 2019; PMC6669412.
199 PMC6554991 Ricardo L Dominguez, Charlotte B Cherry, Dago Estevez-Ordonez, Robertino Mera, Veronica Escamilla, Michael Pawlita, Tim Waterboer, Keith T Wilson (GI), Richard M Peek (GI), Gloria Tavera, Scott M Williams, Margaret L Gulley, Michael Emch, Douglas R Morgan (GI). Geospatial analyses identify regional hot spots of diffuse gastric cancer in rural Central America. BMC Cancer 19(1):545, 2019; PMC6554991.
200 PMC7066869 Noura S Dosoky, Zhongyi Chen, Yan Guo, Clara McMillan, C Robb Flynn (OMN), Sean S Davies (OMN). Two-week administration of engineered Escherichia coli establishes persistent resistance to diet-induced obesity even without antibiotic pre-treatment. Appl Microbiol Biotechnol 103(16):6711-6723, 2019; PMC7066869.
201 PMC6697607 Joseph P Zackular, Leslie Kirk, Bruno C Trindade, Eric P Skaar (GI), David M Aronoff (GI). Misoprostol protects mice against severe Clostridium difficile infection and promotes recovery of the gut microbiota after antibiotic perturbation. Anaerobe 2019; PMC6697607.
202 PMC6726494 Luca D'Agostino, Yingchao Nie, Sayantani Goswami, Kevin Tong, Shiyan Yu, Sheila Bandyopadhyay, Juan Flores, Xiao Zhang, Iyshwarya Balasubramanian, Ivor Joseph, Ryotaro Sakamori, Victoria Farrell, Qi Li, Chung S Yang, Bin Gao, Ronaldo P Ferraris, Ghassan Yehia, Edward M Bonder, James R Goldenring (PC), Michael P Verzi, Lanjing Zhang, Y Tony Ip, Nan Gao. Recycling endosomes in mature epithelia restrain tumorigenic signaling. Cancer Res 79(16):4099-4112, 2019; PMC6726494.
203 PMC7175957 Satya Das, Chanjuan Shi (OMN), Tatsuki Koyama, Yi Huang, Raul Gonzalez, Kamran Idrees, Christina Edwards Bailey, Jordan Berlin (PC). Peritoneal carcinomatosis in well-differentiated small-intestinal neuroendocrine tumors with mesenteric tumor deposits. J Med Surg Pathol 4(1):1-10, 2019; PMC7175957.
204 PMC6781011 Wenhan Zhu (GI), Naoteru Miyata, Maria G Winter, Alexandre Arenales, Elizabeth R Hughes, Luisella Spiga, Jiwoong Kim, Luis Sifuentes-Dominguez, Petro Starokadomskyy, Purva Gopal, Mariana X Byndloss (GI), Renato L Santos, Ezra Burstein, Sebastian E Winter. Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer. J Exp Med 2019; 216(10):2378-2393. PMC6781011.
205 PMC6657322 Moh'd Khushman, Girijesh Kumar Patel, Javier Ariel Laurini, Arun Bhardwaj, Kelly Roveda, Robert Donnell, Kelley Sherling, Brittany Case, Arthur E Frankel, Sachin Pai, William Taylor, Marcus Tan (GI), Meir Mizrahi, Cindy Nelson, Mary Wyatt, Mary Patton, Steven McClellan, Seema Singh, Bin Wang, Ajay P Singh. Exosomal markers (CD63 and CD9) expression and their prognostic significance using immunohistochemistry in patients with pancreatic ductal adenocarcinoma. J Gastrointest Oncol 10(4):695-702, 2019; PMC6657322.
206 PMC8019324 Yash Choksi (GI), Jasmne Chaparro, Michael Blanco, Rohit Sharda, Shabnam Sarker, Sarah Ferguson, Tina Higginbotham, Girish Hiremath, Frank Revetta, M Kay Washington (OMN), Christopher S Williams (GI), Michael F Vaezi. Impedance and histologic characteristics of the sub-laryngeal esophagus distinguish eosinophilic esophagitis from other esophageal disorders. Clin Gastroenterol Hepatol 2019; 18(8):1727-1735. PMC8019324.
207 PMC7948212 Mikiko Watanabe, Garima Singhal, Ffolliott M Fisher, Thomas C Beck, Donald A Morgan, Fabio Socciarelli, Marie L Mather, Renata Risi, Jared Bourke, Kamal Rahmouni, Owen P McGuinness (OMN), Jeffrey S Flier, Eleftheria Maratos-Flier. Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis. Endocrine 2019; 67(1):95-108. PMC7948212.
208 PMC6876593 Mercedes Dávalos-Salas, Magdalene K Montgomery, Camilla M Reehorst, Rebecca Nightingale, Irvin Ng, Holly Anderton, Sheren Al-Obaidi, Analia Lesmana, Cameron M Scott, Paul Ioannidis, Hina Kalra, Shivakumar Keerthikumar, Lars Tögel, Angela Rigopoulos, Sylvia J Gong, David S Williams, Prusoth Yoganantharaja, Kim Bell-Anderson, Suresh Mathivanan, Yann Gibert, Scott Hiebert (GI), Andrew M Scott, Matthew J Watt, John M Mariadason. Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity. Nat Commun 10(1):5291, 2019; PMC6876593.
209 PMC6597297 Saiprasad Gowrikumar, Rizwan Ahmad, Srijayaprakash Babu Uppada, Mary K Washington (OMN), Chanjuan Shi (OMN), Amar B Singh, Punita Dhawan. Upregulated Claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner. Oncogene 38(26):5321-5337, 2019; PMC6597297.
210 PMC6722301 Evans Quilichini, Mélanie Fabre, Thassadite Dirami, Aline Stedman, Matias De Vas, Ozge Ozguc, Raymond C Pasek, Silvia Cereghini, Lucie Morillon, Carmen Guerra, Anne Couvelard, Maureen Gannon (PC), Cécile Haumaitre. Pancreatic ductal deletion of HNF1B disrupts exocrine homeostasis, leads to pancreatitis, and facilitates tumorigenesis. Cell Mol Gastroenterol Hepatol 8(3):487-511, 2019; PMC6722301.
211 PMC5799016 Charles A Herring, Amrita Banerjee, Eliot T McKinley, Alan J Simmons, Jie Ping, Joseph T Roland, Jeffrey L Franklin (PC), Qi Liu, Michael J Gerdes, Robert J Coffey (PC), Ken S Lau (PC). Unsupervised trajectory analysis of single-cell RNA-seq and imaging data reveals alternative tuft cell origins in the gut. Cell Syst 6(1):37-51.e9, 2018; PMC5799016.
212 PMC6619599 Ali Nazmi, Kristen L Hoek, Michael J Greer, Maria B Piazuelo (GI), Nagahiro Minato, Danyvid Olivares-Villagómez (GI). Innate CD8αα+ cells promote ILC1-like intraepithelial lymphocyte homeostasis and intestinal inflammation. PLoS One 14(7):e0215883, 2019; PMC6619599.
213 PMC6803323 Sharia Yasmin, Beverly R E A Dixon, Danyvid Olivares-Villagómez (GI), Holly M Scott Algood (GI). IL-21 down-regulates dendritic cell cytokine responses to and modulates T lymphocyte IL-17A expression in the Peyer's patches during infection. Infect Immun 2019; 87(11):e00237-19. PMC6803323.
214 PMC6305842 Eunyoung Choi (PC), Anna L Means (PC), Robert J Coffey (PC), James R Goldenring (PC). Active Kras expression in gastric isthmal progenitor cells induces foveolar hyperplasia but not metaplasia. Cell Mol Gastroenterol Hepatol 7(1):251-253.e1, 2019; PMC6305842.
215 PMC6586520 Sarah P Short (GI), Caitlyn W Barrett, Kristy R Stengel, Frank L Revetta, Yash A Choksi (GI), Lori A Coburn (OMN), Mary K Lintel, Elizabeth M McDonough, M Kay Washington (OMN), Keith T Wilson (GI), Egor Prokhortchouk, Xi Chen, Scott W Hiebert (GI), Albert B Reynolds (PC), Christopher S Williams (GI). Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma. Oncogene 38(25):5091-5106, 2019; PMC6586520.
216 PMC5919882 Amrita Banerjee, Eliot T McKinley, Jakob von Moltke, Robert J Coffey (PC), Ken S Lau (PC). Interpreting heterogeneity in intestinal tuft cell structure and function. J Clin Invest 128(5):1711-1719, 2018; PMC5919882.
217 PMC6083016 Anna L Means (PC), Tanner J Freeman, Jing Zhu, Luke G Woodbury, Paula Marincola-Smith, Chao Wu, Anne R Meyer, Connie J Weaver, Chandrasekhar Padmanabhan, Hanbing An, Jinghuan Zi, Bronson C Wessinger, Rupesh Chaturvedi, Tasia D Brown, Natasha G Deane, Robert J Coffey (PC), Keith T Wilson (GI), J Joshua Smith, Charles L Sawyers, James R Goldenring (PC), Sergey V Novitskiy, M Kay Washington (OMN), Chanjuan Shi (OMN), R Daniel Beauchamp (PC). Epithelial SMAD4 deletion up-regulates inflammation and promotes inflammation-associated cancer. Cell Mol Gastroenterol Hepatol 6(3):257-276, 2018; PMC6083016.
218 PMC6162166 Yash A Choksi (GI), Vishruth K Reddy, Kshipra Singh, Caitlyn W Barrett, Sarah P Short (GI), Bobak Parang, Cody E Keating, Joshua J Thompson, Thomas G Verriere, Rachel E Brown, M Blanca Piazuelo (GI), David M Bader, M Kay Washington (OMN), Mukul K Mittal, Thomas Brand, Alain P Gobert, Lori A Coburn (OMN), Keith T Wilson (GI), Christopher S Williams (GI). BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Mucosal Immunol 11(5):1363-1374, 2018; PMC6162166.
219 PMC5742304 Robertino M Mera, Luis E Bravo, M Constanza Camargo, Juan C Bravo, Alberto G Delgado, Judith Romero-Gallo, Maria C Yepez, José L Realpe, Barbara G Schneider (GI), Douglas R Morgan (GI), Richard M Peek (GI), Pelayo Correa (GI), Keith T Wilson (GI), M Blanca Piazuelo (GI). Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Gut 67(7):1239-1246, 2018; PMC5742304.
220 PMC5857411 Jennifer M Noto, Abha Chopra, John T Loh (GI), Judith Romero-Gallo, M Blanca Piazuelo (GI), Mark Watson, Shay Leary, Amber C Beckett, Keith T Wilson (GI), Timothy L Cover (GI), Simon Mallal, Dawn A Israel (GI), Richard M Peek (GI). Pan-genomic analyses identify key Helicobacter pylori pathogenic loci modified by carcinogenic host microenvironments. Gut 67(10):1793-1804, 2018; PMC5857411.
221 PMC5985047 Lin Zhu, Jeanne Shi, Thao N Luu, Joshua C Neuman, Elijah Trefts, Sophia Yu, Brian T Palmisano, David H Wasserman (OMN), MacRae F Linton, John M Stafford (OMN). Hepatocyte estrogen receptor alpha mediates estrogen action to promote reverse cholesterol transport during Western-type diet feeding. Mol Metab 8:106-116, 2018; PMC5985047.
222 PMC5966712 Yang Wang, Cindy L Vnencak-Jones, Justin M Cates, Chanjuan Shi (OMN). Deciphering elevated microsatellite alterations at selected Tetra/Pentanucleotide repeats, microsatellite instability, and loss of heterozygosity in colorectal cancers. J Mol Diagn 20(3):366-372, 2018; PMC5966712.
223 PMC5841359 Roshonda B Jones, Xiangzhu Zhu, Emili Moan, Harvey J Murff (OMN), Reid M Ness, Douglas L Seidner, Shan Sun, Chang Yu, Qi Dai (OMN), Anthony A Fodor, M Andrea Azcarate-Peril, Martha J Shrubsole (OMN). Inter-niche and inter-individual variation in gut microbial community assessment using stool, rectal swab, and mucosal samples. Sci Rep 8(1):4139, 2018; PMC5841359.
224 PMC5980194 Masami Yamamoto, Sachiyo Nomura, Akihiro Hosoi, Koji Nagaoka, Tamaki Iino, Tomohiko Yasuda, Tomoko Saito, Hirokazu Matsushita, Eiji Uchida, Yasuyuki Seto, James R Goldenring (PC), Kazuhiko Kakimi, Masae Tatematsu, Tetsuya Tsukamoto. Established gastric cancer cell lines transplantable into C57BL/6 mice show fibroblast growth factor receptor 4 promotion of tumor growth. Cancer Sci 109(5):1480-1492, 2018; PMC5980194.
225 PMC5919534 Robert L Barry, Nellie E Byun, Jason M Williams, Michael A Siuta, Mohammed N Tantawy, Nicole K Speed, Christine Saunders, Aurelio Galli, Kevin D Niswender (OMN), Malcolm J Avison. Brief exposure to obesogenic diet disrupts brain dopamine networks. PLoS One 13(4):e0191299, 2018; PMC5919534.
226 PMC5957394 Keith A Martinez, Joann Romano-Keeler, Joseph P Zackular, Daniel J Moore (OMN), Robert M Brucker, Christopher Hooper, Shufang Meng, Naoko Brown, Simon Mallal, Jeff Reese, David M Aronoff (GI), Hakdong Shin, Maria Gloria Dominguez-Bello, Jörn-Hendrik Weitkamp (GI). Bacterial DNA is present in the fetal intestine and overlaps with that in the placenta in mice. PLoS One 13(5):e0197439, 2018; PMC5957394.
227 PMC5961626 Amber C Beckett, John T Loh (GI), Abha Chopra, Shay Leary, Aung Soe Lin, Wyatt J McDonnell, Beverly R E A Dixon, Jennifer M Noto, Dawn A Israel (GI), Richard M Peek (GI), Simon Mallal, Holly M Scott Algood (GI), Timothy L Cover (GI). Helicobacter pylori genetic diversification in the Mongolian gerbil model. PeerJ 6:e4803, 2018; PMC5961626.
228 PMC6692915 Matthew E Bechard, Anna E Word, Amanda V Tran, Xiaojing Liu, Jason W Locasale, Oliver G McDonald (PC). Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases. Oncogene 37(38):5248-5256, 2018; PMC6692915.
229 PMC6042974 Aaron A May-Zhang, Karen K Deal, E Michelle Southard-Smith (PC). Optimization of laser-capture microdissection for the isolation of enteric ganglia from fresh-frozen human tissue. J Vis Exp (136), 2018; PMC6042974.
230 PMC6002410 Philip E Dubé, Cambrian Y Liu, Nandini Girish, M Kay Washington (OMN), D Brent Polk. Pharmacological activation of epidermal growth factor receptor signaling inhibits colitis-associated cancer in mice. Sci Rep 8(1):9119, 2018; PMC6002410.
231 PMC6421579 Mariano J Alvarez, Prem S Subramaniam, Laura H Tang, Adina Grunn, Mahalaxmi Aburi, Gabrielle Rieckhof, Elena V Komissarova, Elizabeth A Hagan, Lisa Bodei, Paul A Clemons, Filemon S Dela Cruz, Deepti Dhall, Daniel Diolaiti, Douglas A Fraker, Afshin Ghavami, Daniel Kaemmerer, Charles Karan, Mark Kidd, Kyoung M Kim, Hee C Kim, Lakshmi P Kunju, Ülo Langel, Zhong Li, Jeeyun Lee, Hai Li, Virginia LiVolsi, Roswitha Pfragner, Allison R Rainey, Ronald B Realubit, Helen Remotti, Jakob Regberg, Robert Roses, Anil Rustgi, Antonia R Sepulveda, Stefano Serra, Chanjuan Shi (OMN), Xiaopu Yuan, Massimo Barberis, Roberto Bergamaschi, Arul M Chinnaiyan, Tony Detre, Shereen Ezzat, Andrea Frilling, Merten Hommann, Dirk Jaeger, Michelle K Kim, Beatrice S Knudsen, Andrew L Kung, Emer Leahy, David C Metz, Jeffrey W Milsom, Young S Park, Diane Reidy-Lagunes, Stuart Schreiber, Kay Washington (OMN), Bertram Wiedenmann, Irvin Modlin, Andrea Califano. A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors. Nat Genet 50(7):979-989, 2018; PMC6421579.
232 PMC6499718 Satya Das, Chanjuan Shi (OMN), Liping Du, Kamran Idrees, Jordan Berlin (PC). Adenocarcinoma ex-goblet cell: a retrospective experience. J Gastrointest Cancer 2018; PMC6499718.
233 PMC6197921 Jordan Roberts, Raul S Gonzalez, Frank Revetta, Chanjuan Shi (OMN). Mesenteric tumour deposits arising from small-intestine neuroendocrine tumours are frequently associated with fibrosis and IgG4-expressing plasma cells. Histopathology 73(5):795-800, 2018; PMC6197921.
234 PMC6245220 Lin Zhu, Thao Luu, Christopher H Emfinger, Bryan A Parks, Jeanne Shi, Elijah Trefts, Fenghua Zeng, Zsuzsanna Kuklenyik, Raymond C Harris, David H Wasserman (OMN), Sergio Fazio, John M Stafford (OMN). CETP inhibition improves HDL function but leads to fatty liver and insulin resistance in CETP-expressing transgenic mice on a high-fat diet. Diabetes 2018; PMC6245220.
235 PMC6203398 Joann Romano-Keeler, Meghan H Shilts, Andrey Tovchigrechko, Chunlin Wang, Robert M Brucker, Daniel J Moore (OMN), Christopher Fonnesbeck, Shufang Meng, Hernan Correa, Harold N Lovvorn, Yi-Wei Tang, Lora Hooper, Seth R Bordenstein (GI), Suman R Das, Jörn-Hendrik Weitkamp (GI). Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure. PLoS One 13(10):e0206366, 2018; PMC6203398.
236 PMC6331005 Sho Morioka, Justin S A Perry, Michael H Raymond, Christopher B Medina, Yunlu Zhu, Liyang Zhao, Vlad Serbulea, Suna Onengut-Gumuscu, Norbert Leitinger, Sarah Kucenas, Jeffrey C Rathmell (OMN), Liza Makowski, Kodi S Ravichandran. Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. Nature 563(7733):714-718, 2018; PMC6331005.
237  PMC5923068 Judy J Brown, Sarah P Short (GI), Jennifer Stencel-Baerenwald, Kelly Urbanek, Andrea J Pruijssers, Nicole McAllister, Mine Ikizler, Gwen Taylor, Pavithra Aravamudhan, Solomiia Khomandiak, Bana Jabri, Christopher S Williams (GI), Terence S Dermody. Reovirus-induced apoptosis in the intestine limits establishment of enteric infection. J Virol 92(10), 2018; PMC5923068.
238 PMC5413443 Giovanni Suarez, Judith Romero-Gallo, Johanna C Sierra, M Blanca Piazuelo (GI), Uma S Krishna, Martin A Gomez, Keith T Wilson (GI), Richard M Peek (GI). Genetic manipulation of Helicobacter pylori virulence function by host carcinogenic phenotypes. Cancer Res 77(9):2401-2412, 2017; PMC5413443.
239 PMC5541935 Timothy Su, M Kay Washington (OMN), Reid M Ness, Douglas K Rex, Walter E Smalley, Thomas M Ulbright, Qiuyin Cai, Wei Zheng (OMN), Martha J Shrubsole (OMN). Comparison of biomarker expression between proximal and distal colorectal adenomas: The Tennessee-Indiana Adenoma Recurrence Study. Mol Carcinog 56(2):761-773, 2017; PMC5541935.
240 PMC5334457 Shoumin Zhu, Mohammed Soutto, Zheng Chen, DunFa Peng, Judith Romero-Gallo, Uma S Krishna, Abbes Belkhiri (PC), M Kay Washington (OMN), Richard Peek (GI), Wael El-Rifai (PC). Helicobacter pylori-induced cell death is counteracted by NF-κB-mediated transcription of DARPP-32. Gut 66(5):761-762, 2017; PMC5334457.
241 PMC5159256 Cynthia R Fata, Raul S Gonzalez, Eric Liu, Justin M Cates, Chanjuan Shi (OMN). Mesenteric tumor deposits in midgut small intestinal neuroendocrine tumors are a stronger indicator than lymph node metastasis for liver metastasis and poor prognosis. Am J Surg Pathol 41(1):128-133, 2017; PMC5159256.
242 PMC6420777 Raul S Gonzalez, Michael A Gilger, Won Jae Huh (PC), Mary Kay Washington (OMN). The spectrum of histologic findings in hepatic outflow obstruction. Arch Pathol Lab Med 141(1):98-103, 2017; PMC6420777.
243 PMC6476310 Michael L Schulte, Matthew R Hight, Gregory D Ayers, Qi Liu, Yu Shyr, M Kay Washington (OMN), H Charles Manning (PC). Non-invasive glutamine PET reflects pharmacological inhibition of BRAF in vivo. Mol Imaging Biol 19(3):421-428, 2017; PMC6476310.
244 PMC5225298 Yang Wang, Chanjuan Shi (OMN), Rosana Eisenberg, Cindy L Vnencak-Jones. Differences in microsatellite instability profiles between endometrioid and colorectal cancers: a potential cause for false-negative results? J Mol Diagn 19(1):57-64, 2017; PMC5225298.
245 PMC5391042 Joseph Burclaff, Luciana H Osaki, Dengqun Liu, James R Goldenring (PC), Jason C Mills. Targeted apoptosis of parietal cells is insufficient to induce metaplasia in stomach. Gastroenterology 152(4):762-766.e7, 2017; PMC5391042.
246 PMC5503809 Ahmed Katsha, Lihong Wang, Janet Arras, Omar M Omar, Jeffrey Ecsedy, Abbes Belkhiri (PC), Wael El-Rifai (PC). Activation of EIF4E by Aurora kinase A depicts a novel druggable axis in everolimus-resistant cancer cells. Clin Cancer Res 23(14):3756-3768, 2017; PMC5503809.
247 PMC5244375 DunFa Peng, Yan Guo, Heidi Chen, Shilin Zhao, Kay Washington (OMN), TianLing Hu, Yu Shyr, Wael El-Rifai (PC). Integrated molecular analysis reveals complex interactions between genomic and epigenomic alterations in esophageal adenocarcinomas. Sci Rep 7:40729, 2017; PMC5244375.
248 PMC5406257 Michael J Rosen, Rebekah Karns, Jefferson E Vallance, Ramona Bezold, Amanda Waddell, Margaret H Collins, Yael Haberman, Phillip Minar, Robert N Baldassano, Jeffrey S Hyams, Susan S Baker, Richard Kellermayer, Joshua D Noe, Anne M Griffiths, Joel R Rosh, Wallace V Crandall, Melvin B Heyman, David R Mack, Michael D Kappelman, James Markowitz, Dedrick E Moulton, Neal S Leleiko, Thomas D Walters, Subra Kugathasan, Keith T Wilson (GI), Simon P Hogan, Lee A Denson. Mucosal expression of type 2 and type 17 immune response genes distinguishes ulcerative colitis from colon-only Crohn's disease in treatment-naive pediatric patients. Gastroenterology 152(6):1345-1357.e7, 2017; PMC5406257.
249 PMC5340240 Hiroshi Nakase, Shinji Sakuma, Takumi Fukuchi, Takuya Yoshino, Kohta Mohri, Kohei Miyata, Hironori Kumagai, Ken-Ichiro Hiwatari, Kazufumi Tsubaki, Tetsuya Ikejima, Etsuo Tobita, Meiying Zhu, Kevin J Wilson, Kay Washington (OMN), John C Gore, Wellington Pham. Evaluation of a novel fluorescent nanobeacon for targeted imaging of Thomsen-Friedenreich associated colorectal cancer. Int J Nanomedicine 12:1747-1755, 2017; PMC5340240.
250 PMC5564545 Jone Garay, M Blanca Piazuelo (GI), Lizbeth Lopez-Carrillo, Yelda A Leal, Sumana Majumdar, Li Li, Nataly Cruz-Rodriguez, Silvia J Serrano-Gomez, Carlos S Busso, Barbara G Schneider (GI), Alberto G Delgado, Luis E Bravo, Angela M Crist, Stryder M Meadows, M Constanza Camargo, Keith T Wilson (GI), Pelayo Correa (GI), Jovanny Zabaleta. Increased expression of deleted in malignant brain tumors (DMBT1) gene in precancerous gastric lesions: Findings from human and animal studies. Oncotarget 8(29):47076-47089, 2017; PMC5564545.
251 PMC5524517 Zheng Chen, Mohammed Soutto, Bushra Rahman, Muhammad W Fazili, DunFa Peng, Maria Blanca Piazuelo, Heidi Chen, M Kay Washington (OMN), Yu Shyr, Wael El-Rifai (PC). Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia. Genes Chromosomes Cancer 56(7):535-547, 2017; PMC5524517.
252 PMC5391403 Alvaro Pazos, Nuri Kodaman, M Blanca Piazuelo (GI), Judith Romero-Gallo, Rafal S Sobota, Dawn A Israel (GI), Luis E Bravo, Douglas R Morgan (GI), Keith T Wilson (GI), Pelayo Correa (PC), Richard M Peek (GI), Scott M Williams, Barbara G Schneider (GI). Draft genome sequences of 13 Colombian Helicobacter strains isolated from Pacific coast and Andean residents. Genome Announc 5(15), 2017; PMC5391403.
253 PMC5591948 Nina Bertaux-Skeirik, Mark Wunderlich, Emma Teal, Jayati Chakrabarti, Jacek Biesiada, Maxime Mahe, Nambirajan Sundaram, Joel Gabre, Jennifer Hawkins, Gao Jian, Amy C Engevik, Li Yang, Jiang Wang, James R Goldenring (PC), Joseph E Qualls, Mario Medvedovic, Michael A Helmrath, Tayyab Diwan, James C Mulloy, Yana Zavros. CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium. J Pathol 242(4):463-475, 2017; PMC5591948.
254 PMC5537695 Lihong Wang, Janet Arras, Ahmed Katsha, Saif Hamdan, Abbes Belkhiri (PC), Jeffrey Ecsedy, Wael El-Rifai (PC). Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib. Mol Oncol 11(8):981-995, 2017; PMC5537695.
255 PMC5559000 Matthew C Surdel, Dennis J Horvath, Lisa J Lojek, Audra R Fullen, Jocelyn Simpson, Brendan F Dutter, Kenneth J Salleng, Jeremy B Ford, J Logan Jenkins, Raju Nagarajan, Pedro L Teixeira, Matthew Albertolle, Ivelin S Georgiev, E Duco Jansen, Gary A Sulikowski, D Borden Lacy (GI), Harry A Dailey, Eric P Skaar (GI). Antibacterial photosensitization through activation of coproporphyrinogen oxidase. Proc Natl Acad Sci U S A 114(32):E6652-E6659, 2017; PMC5559000.
256 PMC6512312 Rizwan Ahmad, Balawant Kumar, Z Chen, X Chen, D Müller, S M Lele, M Kay Washington (OMN), S K Batra, Punita Dhawan, Amar B Singh. Loss of Claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling. Oncogene 36(47):6592-6604, 2017; PMC6512312.
257 PMC5560519 Amanda D Williams, Olga Y Korolkova, Amos M Sakwe, Timothy M Geiger, Samuel D James, Roberta L Muldoon, Alan J Herline, J Shawn Goodwin, Michael G Izban, Mary K Washington (OMN), Duane T Smoot, Billy R Ballard, Maria Gazouli, Amosy E M'Koma. Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One 12(8):e0179710, 2017; PMC5560519.
258 PMC5745271 Jordan A Roberts, Raul S Gonzalez, Satya Das, Jordan Berlin (PC), Chanjuan Shi (OMN). Expression of PD-1 and PD-L1 in poorly differentiated neuroendocrine carcinomas of the digestive system: A potential target for anti-PD-1/PD-L1 therapy. Hum Pathol 70:49-54, 2017; PMC5745271.
259  PMC6543885 Raul S Gonzalez, Justin M M Cates, Frank Revetta, Loralee A McMahon, Kay Washington (OMN). Gastric carcinomas with lymphoid stroma: Categorization and comparison with solid-type colonic carcinomas. Am J Clin Pathol 148(6):477-484, 2017; PMC6543885.
260 PMID:29248733 Yash Choksi (GI), Pooja Lal, James C Slaughter, Rohit Sharda, Jacob Parnell, Tina Higginbotham, Michael F Vaezi. Esophageal mucosal impedance patterns discriminate patients with eosinophilic esophagitis from patients with GERD. Clin Gastroenterol Hepatol 2017; PMID:29248733.
261 PMC5549975 Larry L Swift, Joseph D Love, Carla M Harris, Benny H Chang, W Gray Jerome. Microsomal triglyceride transfer protein contributes to lipid droplet maturation in adipocytes. PLoS One. 2017 Aug 9;12(8):e0181046. doi: 10.1371/journal.pone.0181046. PMID: 28793320; PMCID: PMC5549975.
262 PMC8090972 John T Loh (GI), Miranda V Shum, Scott D R Jossart, Anne M Campbell, Neha Sawhney, W Hayes McDonald, Matthew B Scholz, Mark S McClain (GI), Mark H Forsyth, Timothy L Cover (GI). Delineation of the pH-responsive regulon controlled by the ArsRS two-component system. Infect Immun 2021; PMC8090972.
263 PMC7282982 Amy C Engevik, Alexander W Coutts, Izumi Kaji, Paula Rodriguez, Felipe Ongaratto, Milena Saqui-Salces, Ramya Lekha Medida, Anne R Meyer, Elena Kolobova, Melinda A Engevik, Janice A Williams, Mitchell D Shub, Daniel F Carlson, Tamene Melkamu, James R Goldenring (PC). Editing myosin VB gene to create porcine model of microvillus inclusion disease, with microvillus-lined inclusions and alterations in sodium transporters. Gastroenterology 158(8):2236-2249.e9, 2020; PMC7282982.
264 PMC7956217 Alain P Gobert, Olivier Boutaud, Mohammad Asim, Irene A Zagol-Ikapitte, Alberto G Delgado, Yvonne L Latour, Jordan L Finley, Kshipra Singh, Thomas G Verriere, Margaret M Allaman, Daniel P Barry, Kara M McNamara, Johanna C Sierra, Venkataraman Amarnath, Mohammed N Tantawy, Diane Bimczok, M Blanca Piazuelo (GI), M Kay Washington (OMN), Shilin Zhao, Lori A Coburn (OMN), Keith T Wilson (GI). Dicarbonyl electrophiles mediate inflammation-induced gastrointestinal carcinogenesis. Gastroenterology 2020; 160(4):1256-1268.e9. PMC7956217.
265 PMC7260102 Johanna C Sierra, M Blanca Piazuelo (GI)