Tables for Allergy NLP Matching

April 15, 2015
The system was developed and tested using a perioperative management system using a training set of 24,599 entries and a test set of 24,857 entries from Vanderbilt University.  Our goal was to develop a high performance, easily-maintained algorithm to identify medication and food allergies and sensitivities from unstructured allergy entries in electronic medical record (EHR) systems.

PheWAS - phenome-wide association studies

April 15, 2015
Methods to identify gene-disease associations primarily rely on clinical trials or observational cohorts and, more recently, Electronic Medical Record-linked DNA Biobanks.  At Vanderbilt, we have used an EMR-linked DNA biobank called BioVU to derive case and controls populations using data within the EMR to define clinical phenotypes.  Genetic data for these EMR-linked association studies are redeposited into BioVU for future EMR-linked studies.  This has opened the possibility of "reverse GWAS" or "Phenome-wide association studies" (PheWAS).&n

PheWAS - phenome-wide association studies

April 8, 2015
Posted in
Genomics/Pharmacogenomics
PheWAS using ICD9 codes Our EMR-based PheWAS uses a custom-developed grouping of International Classification of Disease, 9th edition (ICD9) codes.  These grouping loosely follow the 3-digit (category) and section groupings defined with the ICD9 code system itself, but vary to include, for example, all hypertension codes (401-405) as one grouping.  Each custom PheWAS code group also has an associated control group that excludes other related conditions (e.g., a patient with Graves disease cannot be a control for thyroiditis).    

Phewas - Phenome Wide Association Studies

March 18, 2015
Methods to identify gene-disease associations primarily rely on clinical trials or observational cohorts and, more recently, Electronic Medical Record-linked DNA Biobanks.  At Vanderbilt, we have used an EMR-linked DNA biobank called BioVU to derive case and controls populations using data within the EMR to define clinical phenotypes.  Genetic data for these EMR-linked association studies are redeposited into BioVU for future EMR-linked studies.  This has opened the possibility of "reverse GWAS" or "Phenome-wide association studies" (PheWAS). 

PheWAS - Phenome-Wide Association Studies

May 1, 2013
Posted in
PheWAS, Genomics/Pharmacogenomics
Methods to identify gene-disease associations primarily rely on clinical trials or observational cohorts and, more recently, Electronic Medical Record-linked DNA Biobanks.  At Vanderbilt, we have used an EMR-linked DNA biobank called BioVU to derive case and controls populations using data within the EMR to define clinical phenotypes.  Genetic data for these EMR-linked association studies are redeposited into BioVU for future EMR-linked studies.  This has opened the possibility of "reverse GWAS" or "Phenome-wide association studies" (PheWAS). 

Nature Biotech article on PheWAS

January 30, 2011
Nature Biotech featured PheWAS paper as one of the top computational biology innovations in 2010.http://www.nature.com/nbt/journal/v29/n1/full/nbt0111-46.html
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