Pulmonary Hypertension/Right Heart Failure
Ukita R, Wu W, Liang J, Talackine JR, Patel Y, Francois SA, Cardwell NL, Flynn CR, Shingina A, Washington MK, Trinh VQ, Bacchetta M, Alexopoulos SP. Pulmonary artery banding in sheep: A novel large animal model for congestive hepatopathy. J Appl Physiol. 2023 Apr 1;134(4):840-845. Link: https://pubmed.ncbi.nlm.nih.gov/36759164/
Ukita R, Stokes JW, Wu WK, Patel Y, Talackine JR, Cardwell N, Benson C, Lefevre RJ, Eagle S, Demarest C, Simonds E, Tipograf Y, Cortelli M, Skoog DJ, Cook K, Rosenzweig EB, Bacchetta M. Large animal preclinical investigation into the optimal extracorporeal life support configuration for pulmonary hypertension and right ventricular failure. J Heart Lung Transplant. 2023 Jul; 42(7):859-867. Link: https://pubmed.ncbi.nlm.nih.gov/36435685/
Ukita R, Patel YJ, Wu WK, Francois SA, Cortelli M, Johnson CA, Cardwell N, Talackine JR, Stokes JW, Grogan W, Mentz M, Tracy KM, Harris TR, Tucker W, Simonds E, Demarest CT, Cook KE, Skoog DJ, Rosenzwieg EB, Bacchetta M. Ambulatory 7-day mechanical circulatory support in a sheep model of pulmonary hypertension and right heart failure. J Heart Lung Transplant. 2024 Feb;43(2):293-302. Link: https://pubmed.ncbi.nlm.nih.gov/37907183/
Bulard BA, Kumpfbeck AR, Woo Y, Simonds E, Adesanya T, Glomp G, Schanz B, Said B, Kane S, Cagnolatti C, Petrovic M, Bapatla S, Adjei E, Austin E, Stokes J, Demarest CT, Ukita R, Bacchetta M. Structured Exercise Regimen in Pulmonary Hypertension-Right Ventricular Failure in an Ovine Model. Journal of Visualized Experiments (JoVE). 2026(231). doi: 10.3791/70664. Link: https://pubmed.ncbi.nlm.nih.gov/42184261/
Ukita, R. et al. Left Pulmonary Artery Ligation and Chronic Pulmonary Artery Banding Model for Inducing Right Ventricular - Pulmonary Hypertension in Large Pre-Clinical Model. ASAIO Journal E44–E48 (2021) doi:10.1097/MAT.0000000000001197. Link: https://pubmed.ncbi.nlm.nih.gov/33346995/
Ukita, R. et al. A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Large Pre-Clinical Model. Journal of visualized experiments : JoVE (2021). Link: https://pubmed.ncbi.nlm.nih.gov/34338672/
Ukita, R. et al. Progression Toward Decompensated Right Ventricular Failure in the Large Pulmonary Hypertension Model. ASAIO Journal 68, E29–E33 (2022). Link: https://pubmed.ncbi.nlm.nih.gov/33883506/
Cross Circulation
Wu WK, O’Neill JD, Guenthart BA, Hozain AE, Stokes JW, Ukita R, Patel YJ, Pinezich MP, Talackine JR, Cardwell NL, Fung K, Vunjak-Novakovic G, Bacchetta M. Technique for xenogeneic cross-circulation to support human donor lungs ex vivo. J Heart Lung Transplant. 2023 Mar; 42(3):335-344. Link: https://pubmed.ncbi.nlm.nih.gov/36456408/
Wu WK, Stier MT, Stokes JW, Ukita R, Patel Y, Cortelli M, Patel Y, Landstreet LR, Talackine JR, Cardwell NL, Simonds EM, Mentz M, Lowe C, Benson C, Demarest CT, Alexopoulos SP, Shaver CM, Bacchetta M. Immune characterization of a xenogeneic human lung cross-circulation support system. Sci Adv. 2023 Mar 31;9(13): eade7647. Link: https://pubmed.ncbi.nlm.nih.gov/37000867/
Shaver C, Bacchetta M. Immune recognition of porcine organs transplanted into humans. Lancet. 2023 Sep 30;402(10408):1112-1113. PMID: 37598689. Link: https://pubmed.ncbi.nlm.nih.gov/37598689/
Wu WK, Ukita R, Cortelli M, Patel Y, Trinh V, Ziogas I, Francois S, Mentz M, Cardwell N, Talackine J, Grogan W, Stokes JW, Lee Y, Kim J, Alexopoulos S, Bacchetta M. Xenogeneic cross-circulation for physiologic support and recovery of ex vivo human livers. Hepatology. 2023 Sep 1;78(3):820-834. PMID: 36988383 | PMCID: PMC10440302. Link: https://pubmed.ncbi.nlm.nih.gov/36988383/
Shaver CM, Reese PP, Griesemer A, Zuckermann A, Bacchetta M. Scientific advances in the assessment, modification, and generation of transplantable organs for patients with end-stage organ diseases. Lancet. 2025 Jun 30:S0140-6736(25)00239-9. Link: https://pubmed.ncbi.nlm.nih.gov/40614745/
Tracy KM, Harris TR, Petrovic M, Cortelli M, Tucker W, François S, Shishido Y, Victoria Simon V, Petree B, Johnson, Jr. CA, Wu WK, Cardwell NL, Simonds E, Adesanya TT, Fortier AK, Raietparvar K, Landstreet SR, Wickersham N, O’Neill JD, Poland J, Shah AS, DeVries S, Crannell C, Marboe CC, Ukita R, Demarest CT, Shaver CM, Bacchetta M. Lung rehabilitation using xenogeneic cross-circulation does not lead to hyperacute rejection in a human lung transplantation model. J Heart Lung Transplant. 2025 Jul;44(7):1122-1134. Link: https://pubmed.ncbi.nlm.nih.gov/40120998/
Hozain A, E. et al. Multiday maintenance of extracorporeal lungs using cross-circulation with conscious pre-clinical model. Journal of Thoracic and Cardiovascular Surgery, vol. 159 1640-1653.e18 (Mosby Inc., 2020). Link: https://pubmed.ncbi.nlm.nih.gov/31761338/
Hozain A, E. et al. Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs. Nature Medicine 26, 1102–1113 (2020). Link: https://pubmed.ncbi.nlm.nih.gov/32661401/
Wu WK, Ukita R, Stokes JW, Hozain A, et al. Cross-Circulation for Extracorporeal Liver Support in a Large Pre-Clinical Model. ASAIO Journal (2021) doi:10.1097/MAT.0000000000001543. Link: https://pubmed.ncbi.nlm.nih.gov/34352819/
Guenthart, B. A. et al. Regeneration of severely damaged lungs using an interventional cross-circulation platform. Nature Communications 10, (2019). Link: https://pubmed.ncbi.nlm.nih.gov/31064987/
ECMO
Tipograf Y, et al. Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation. Annals of Thoracic Surgery 107, 1456–1463 (2019). Link: https://pubmed.ncbi.nlm.nih.gov/30790550/
Tipograf Y, et al. A Dual-Lumen Bicaval Cannula for Venovenous Extracorporeal Membrane Oxygenation. Annals of Thoracic Surgery 109, 1047–1053 (2020). Link: https://pubmed.ncbi.nlm.nih.gov/31863760/
Stokes, J. W. et al. Bleeding, Thromboembolism, and Clinical Outcomes in Venovenous Extracorporeal Membrane Oxygenation. Critical Care Explorations 2, e0267 (2020). Link: https://pubmed.ncbi.nlm.nih.gov/33196049/
Stokes, J. W., Gannon, W. D. & Bacchetta, M. Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplant. Seminars in Respiratory and Critical Care Medicine 42, 380–391 (2021). Link: https://pubmed.ncbi.nlm.nih.gov/34030201/
Gannon, W. D. et al. Association Between Availability of ECMO and Mortality in COVID-19 Patients Eligible for ECMO: A Natural Experiment. American Journal of Respiratory and Critical Care Medicine (2022) doi:10.1164/rccm.202110-2399LE. Link: https://pubmed.ncbi.nlm.nih.gov/35212255/
Novel Techniques for Organ Procurement, Recovery, and Storage
Williams AM, Bommareddi S, McGann KC, Ahmad A, Trahanas J, Lima B, Ruth T, Bearl DW, Harris RE, Byrne RD, West C, Lepore JA, Aycock P, Michaud N, Burrell S, Stripling SA, Dereshgi AT, Coyan G, Bichell D, Kalsi A, Babb AM, Kuntz M, Clark J, Scholl S, Bacchetta M, Shah AS, Orr Y, Mery CM, Beckerman Z. Pediatric Heart Transplantation with Donation after Circulatory Death. New England Journal of Medicine. 2026;395(14). doi: 10.1056/NEJMc2607437. Link: https://pubmed.ncbi.nlm.nih.gov/42842911/
Williams AM, Trahanas JM, Bommareddi S, Lima B, DeVries SA, Lowman J, Ahmad A, Quintana E, Scholl SR, Tsai S, Pedrotty D, Warhoover M, Moneypenny H, Tapia-Ruano S, Bacchetta M, Schlendorf K, Shah AS. Rapid Recovery of Donor Hearts for Transplantation after Circulatory Death. New England Journal of Medicine. 2025;393(3). doi: 10.1056/NEJMoa2500456. Link: https://pubmed.ncbi.nlm.nih.gov/40673585/
Shishido Y, Tracy KM, Petrovic M, Adesanya T, Fortier AK, Raietparvar K, Glomp GA, Simonds E, Harris TR, Simon V, Tucker WD, Petree B, Cortelli M, Cardwell NL, Crannell C, Liang J, Murphy AC, Fields BL, McReynolds M, Demarest CT, Ukita R, Rizzari M, Montenovo M, Magliocca JF, Karp SJ, Rauf MA, Shah AS, Bacchetta M. Novel Dynamic Organ Storage System Enhances Liver Graft Function in a Porcine Donation After Circulatory Death Model. ASAIO J. 2025 Jul 1; 71(7):560-570. Link: https://pubmed.ncbi.nlm.nih.gov/39693205/
Shishido Y, Tracy KM, Cortelli M, Simon V, Raietparvar K, Adesanya T, Petrovic M, Simonds E, Kumpfbeck A, Woo Y, Petree B, Adjei E, Peters JK, Crannell WC, Demarest CT, Ukita R, Liang J, Rizzarri MD, Montenovo MI, Magliocca JF, Karp SJ, Rauf MA, Bacchetta M. Comparison of Cellular and Acellular Perfusate in the Dynamic Organ Storage System Using a Porcine Donation After Circulatory Death Model. ASAIO J. 2026;72(2):e21-e3. Epub 20250825. doi: 10.1097/MAT.0000000000002538. Link: https://pubmed.ncbi.nlm.nih.gov/40853322/
Automation of Extracorporeal Membrane Oxygenation
Glomp G, Cortelli M, Bernicker B, Bacchetta M, Ukita R. Open-access smart blood pump platform for controlling extracorporeal membrane oxygenation. HardwareX. 2025;22. doi: 10.1016/j.ohx.2025.e00644. Link: https://pubmed.ncbi.nlm.nih.gov/40230885/
Glomp G, Bapatla S, Li L, Burke C, Martel A, Woo Y, Kumpfbeck A, Petrovic M, Ukita R. Smart Blood Pump Version 2 for Programmable Extracorporeal Flow with Improved Cross-Compatibility and Ease of Assembly. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC); Toronto, Canada 2026.
Computational Physiological Modeling
Ukita R, Webb JB, Bapatla S, Woo Y, Kumpfbeck AR, Bray A, Bacchetta M, Clipp RB, Keller SP. Patient-specific, computational model of venovenous extracorporeal membrane oxygenation based on pulse physiology engine. Scientific Reports. 2026;16. doi: 10.1038/s41598-026-64133-3.
Roberts KG, Nasim U, Hong Y, Cook KE, Ukita R. Semi-Empirical Model to Predict Blood Flow in an Extracorporeal Respiratory Support Circuit Driven by Ventricular Assist Devices. ASAIO J. 2026;72(11):921-8. Epub 20260319. doi: 10.1097/MAT.0000000000002685. PubMed PMID: 41856012. Link: https://pubmed.ncbi.nlm.nih.gov/41856012/