Urinary tract infections (UTIs) are not only a common urologic ailment, but one of the most widespread medical conditions facing women, men and children around the globe. In order for clinicians to better manage UTIs—and scientists to understand them more deeply—our clinical viewpoint must become personalized, as we study in tandem the afflicted patients and offending pathogens. To these ends, the Vanderbilt Urologic Infection Repository will provide a first-in-kind resource for the biomedical community, creating a massive network of patient-level clinical data and banked microbial strains from patients with real-world infections.