Recommended Reading

Our special guest-Curator for December's Recommended Reading is Maria Hadjifrangiskou, Ph.D., an Associate Director  of VI4.

1. Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut. Reese AT, David LA, et al in eLife, June 19, 2018

2. Regulated Stochasticity in a Bacterial Signaling Network Permits Tolerance to a Rapid Environmental Change. Carey JN, Goulian M, et al in Cell, March 1, 2018

3. Bacteriophages are more virulent to bacteria with human cells than they are in bacterial culture; insights from HT-29 cells. Shan J, Clokie MRJ, et al in Nature, March 23, 2018

4. Candida albicans biofilm–induced vesicles confer drug resistance through matrix biogenesis. Zarnowski R, Andes DR, et al in PLOS Biology, October 8, 2018

This paper by Zarnowski et al., demonstrates that biofilm-specific extracellular vesicles (EV) produced by Candida albicans serve the community by facilitating the distribution of common goods such as extracellular matrix components. 

Reduced EV production by interfering with the ESCRT machinery reduces exopolysaccharide abundance and induces drug hyper-sensitivity.

5. Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions. Thurley K, Wu LF, Altschuler SJ in Cell, March 28, 2018

Modelling cellular conversations! From microbial cells to complex tissue micro-environments, one thing is common: signaling networks exist to facilitate cell-to-cell communication. Here is a scalable modeling framework that tackles cellular conversation using response-time distributions. 

1. Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins. Koppel N, Balskus EP, et al in eLife, May 15, 2018

2. Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion. Herman-Bausier P, Dufrêne EF, et al in Proceedings of the National Academy of Sciences, May 2018

3. Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Pinho-Ribeiro FA, Chiu IM, et al in Cell, May 10, 2018

4. Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry. Winkels H, Wolf D, et al in Circulation Research, June 8, 2018

5. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Shalapour S, Karin M, et al in Nature , November 16, 2017

1. Identification of a Functionally Unique Family of Penicillin-Binding Proteins. Welsh MA; Taguchi A; et al. in Journal of American Chemical Society, November 28, 2017

2. Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia. Baral P; Umans BD; et al. in Nature Medicine, March 5, 2018

3. Extensive impact of non-antibiotic drugs on human gut bacteria. Maier L; Pruteanu M; et al. in Nature Medicine, March 19, 2018

4. Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients. Gopalakrishnan V; Spencer CN et al. in Science, Jannury 5, 2018

5. Functional interrogation and mining of natively paired human VH:VL antibody repertoires. Wang B; DeKosky BJ et al. in Nature Biotechnology, January 8, 2018

1. Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence. Urbano R; Fang, FC; et al. in Cell Host Microbe, May 9, 2018

2. Dietary trehalose enhances virulence of epidemic Clostridium difficile. Collins, J; Britton, A; et al in Nature, January 18, 2018

3. Comprehensive skin microbiome analysis reveals the uniqueness of human skin and evidence for phylosymbiosis within the class Mammalia. Ross, AA; Neufeld, JD; et al. in  PNAS, June 19, 2018

4. Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells. Ma, C; Gretan, TF; et al. in Science, May 25, 2018

5. In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy. Arlauckas, S; Pittet, MJ; et al. in Science Translational Medicine May 10, 2017