Matthew Stier, MD, PhD

Research Summary:
The Stier lab focuses on defining mechanisms of immune dysfunction in human critical illness, including sepsis and acute respiratory distress syndrome. Using primary biospecimens from ICU patients, the lab integrates high-dimensional cytometry, perturbation studies, metabolic flux analysis, and single-cell transcriptomics to understand how immune cells fail or adapt during severe illness. A central theme is the dynamic nature of immune responses in critical illness, with particular attention to how metabolic stress shapes adaptive versus maladaptive trajectories as patients progress toward recovery, persistent organ failure, or death. In parallel, the lab pursues methods development to expand the scope of mechanistic investigation that can be performed directly in humans. The overarching goal is to leverage these mechanistic insights to identify and prioritize therapeutic targets with the intent of restoring effective immunity in ICU patients.