Post-transcriptional gene regulation in innate immunity and cellular stress
The Ascano laboratory is broadly interested in two areas of cellular stress:
- The roles and coordination of RNA-binding proteins in regulating gene expression during cellular stress.
- The cytosolic DNA-sensing pathway involving the sensor cGAS, its second messenger product cGAMP, and the endoplasmic reticulum-bound receptor STING.
Our lab integrates novel biochemical, molecular and cell biological tools with high-throughput transcriptomic and proteomic technologies in an effort to elucidate the gene regulatory networks at play during cellular stress – and how such mechanisms might be manipulated for therapeutic intervention. The lab is affiliated with the Department of Biochemistry at the Vanderbilt University School of Medicine and is also part of the Immunology and Microbial Pathogenesis Programs within the Department of Pathology, Microbiology, and Immunology at VUMC.