Translational research in acute lung injury and sepsis focusing on molecular mechanisms, tissue factor, coagulation cascade, cell-free hemoglobin and gender
The goal of my research program is to understand the pathophysiology of acute respiratory distress syndrome (ARDS) and sepsis and to uncover novel approaches to prevention and treatment of these devastating conditions. As a physician-scientist, my aim is to uncover novel mechanisms that contribute to the development of sepsis and ARDS with the ultimate goal of identifying new biologic targets and unique therapeutic approaches that can be translated to clinical practice.
My lab has two major focus areas: the role of cell free-hemoglobin in modulating endothelial and lung epithelial permeability in sepsis and ARDS and the role of tissue factor, the initiator of the extrinsic coagulation cascade, in mediating lung epithelial injury and repair. I have experience with mouse models of acute lung injury as well as with modeling the epithelial barrier for in vitro study. I have developed several novel murine and cell culture model systems to study the function of TF in ALI. My research is translational and combines studies in cell culture, human and mouse experimental models, and human samples from patients with sepsis and ARDS.