Dr. Narasimhamurthy is an assistant professor of Pathology, Microbiology, and Immunology at Vanderbilt University Medical Center (VUMC). Before joining VUMC, he practiced pathology for ten years in Botswana, where he held various positions, including assistant program director of the pathology residency program at the University of Botswana and the National Health Laboratory (NHL).

During his time in Botswana, he played a key role in developing a pathology residency program, securing laboratory accreditation, expanding diagnostic services through the introduction of immunohistochemistry, and establishing multidisciplinary breast and gynecological tumor board meetings.

In 2017, the Department of Pathology at NHL received the award for the Best Public Health Initiative from the Botswana Ministry of Health and Wellness for its work on rapid pathology evaluations of fine needle aspiration procedures conducted on-site at health clinics led by Dr. Narasimhamurthy.

He has taught medical students, pathology residents, laboratory scientists, Fulbright Scholars, and Master of Philosophy (MPhil) students. His projects and publications primarily focus on human papillomavirus (HPV) genotyping, breast cancer research, and enhancing diagnostic services.