Mark E. Frisse, MD, MS, MBA, FACMI

Professor Emeritus
Department of Biomedical Informatics
Office Address
2525 West End Avenue
Room / Suite


Mark Frisse, MD, MS, is Professor Emeritus of Biomedical Informatics in the School of Medicine at Vanderbilt University. His work focuses on the intersection between health care informatics, economics, policy, and health care transformation. His primary research is directed toward an understanding of economic sustainability and toward the development of technical and administrative measures to enable effective care coordination and to ensure the integrity of security and privacy efforts. 

In Tennessee, Dr. Frisse led the development and oversight of a six-year federal- and state-sponsored effort to create and operate a health information exchange for the greater Memphis area. This exchange currently has over 7 million records covering the care of over 1.2 million individuals and is now managed completely by a Memphis-based board and a commercial vendor. He has also worked with other states and communities to develop their HIT programs. He also directed the the executive-level Masters of Management in Health Care program at the Vanderbilt Owen Graduate School of Management.

A board certified internist, Dr. Frisse was a Professor of Medicine and Associate Dean at Washington University School of Medicine and he served as academic director of the Health Services Executive MBA program at the John M. Olin School of Business. In his capacity as Associate Dean, he served as the Director of the Bernard Becker Medical Library and established the School's first common technology infrastructure supporting networks, email, educational computing, and digital library services. He founded the Medical Informatics Laboratory within the Department of Medicine and served as a Director of a National Library of Medicine Training Program in Biomedical Informatics. In collaboration with the BJC System, he and his colleagues developed several innovative applications for adverse drug event prevention. He also developed early hypertext systems and directed an IAIMS Planning Grant. 

Prior to assuming his position at Vanderbilt, Dr. Frisse was Vice President in First Consulting Group’s Clinical Transformation Practice working to advance quality and safety through the application of technology, process redesign, evaluation techniques, and evidence-based practice. His experience includes quality and financial analysis, key metrics assessment, clinical visioning, strategy, vendor selection, pre-implementation planning, and clinical quality program alignment. In addition to participating in numerous short-term planning and evaluation engagements, Dr. Frisse served as an operational Vice President overseeing two large-scale transformation and clinical systems implementation efforts.

Prior to joining First Consulting Group, Dr. Frisse was Chief Medical Officer and Vice President, Clinical Information Services at Express Scripts, one of the Nation's largest independent pharmaceutical benefits management concerns. He served as general manager for their Practice Patterns Science subsidiary - a firm applying integrated medical and pharmaceutical claims data to reduce practice variation to a client list that included Blue Cross / Blue Shield of Missouri and Humana. He participated in the formation of RxHub - a new approach to electronic transmission of prescriptions from physicians to pharmacies. He was also responsible for the Express Scripts' DrugDigest consumer Web site and was active in the development of Express Scripts' consumer e-business strategy.

Dr. Frisse received his MD and MBA from Washington University and received a master’s degree in Medical Information Science from Stanford University. Active in medical informatics for 20 years, he is the author of approximately 60 scientific papers, reviews, and book chapters on medical informatics. He served as a consultant for numerous government agencies and health care concerns. He was a member of the National Research Council’s Committee on Enhancing the Internet for Health Applications and more recently was an author of a national report on ePrescribing prepared by the eHealth Initiative. He also has authored works on laboratory data exchange interoperability and the financial impact of e-prescribing.  He serves on the Board of the NCPDP Foundation. Previously, he served on the boards of the eHealth Initiative and SureScripts, LLC. He is a member of the National Academy of Medicine.


Research Information