PLoS Genetics: High-Throughput Framework for Genetic Analyses of Adverse Drug RXNs Using EHRs

On June 1, 2021, faculty and staff from Vanderbilt University Medical Center and the Tennessee Valley Healthcare System published a new study titled "High-Throughput Framework for Genetic Analyses of Adverse Drug Reactions Using Electronic Health Records." The study was published in PLoS Genetics

The researchers presented a high-throughput framework to efficiently identify eligible patients for genetic studies of adverse drug reactions (ADRs) using “drug allergy” labels from electronic health records (EHRs).

Their results demonstrated the potential of utilizing EHRs and their framework to efficiently generate pharmacogenomic findings, which can provide insights for optimizing drug therapy with maximal efficacy and minimal adverse effects.

Faculty and staff from VUMC's Department of Biomedical Informatics include Neil Zheng, Wei-Qi Wei, Eric Vern Kerchberger, Dan Roden and Joshua Denny

Read the study here