The IRBshare System is a new shared IRB review model for multi-site studies comprised of Participating Institutions utilizing Shared Review Documents and a Shared Review Process, supported by a centralized, secure web portal and the IRBshare Master Agreement ('IMA'). IRBshare aims to optimize human research protections through building trust, enhancing communication, and sharing best practices between IRBs nationwide. (www.iirbshare.org)