Vanderbilt Reporter feature on Dr. Angela Jefferson's research linking perivascular spaces & worse cognition

March 27, 2019

Enlarged perivascular spaces, which are commonly seen on brain MRIs in older adults, have important associations with worse cognitive performance, particularly information processing speed and executive function, according to a new study that challenges historical consideration that perivascular spaces are a harmless imaging marker.

Vanderbilt Reporter feature on Dr. Angela Jefferson's research linking aortic stiffness with lower cerebral blood flow

November 28, 2018

Greater aortic stiffness is related to lower cerebral blood flow, especially among individuals with an increased genetic predisposition to Alzheimer’s disease, according to research from Vanderbilt University Medical Center. The study, published recently in Circulation, supports emerging evidence that arterial stiffness, a hypertension-related factor, may play a role in cognitive decline, said Angela Jefferson, PhD, professor of Neurology and director of the Vanderbilt Memory and Alzheimer’s Center.

Study provides robust evidence of sex differences with Alzheimer's gene

May 8, 2018

The APOE gene, the strongest genetic risk factor for Alzheimer’s disease, may play a more prominent role in disease development among women than men, according to new research from the Vanderbilt Memory and Alzheimer’s Center.   The research confirmed recent studies that carrying the APOE ε4 allele has a greater association with Alzheimer’s disease among women compared to men, and went one step further by evaluating its association with amyloid and tau levels.   The study published May 7 in JAMA Neurology adds to mounting evidence that the h

Vanderbilt Reporter feature on Dr. Angela Jefferson's research linking heart function to brain’s memory center

November 9, 2017

Research by a team of Vanderbilt University Medical Center (VUMC) scientists suggests that older people whose hearts pump less blood have blood flow reductions in the temporal lobe regions of the brain, where Alzheimer’s pathology first begins.   The brain, which accounts for only 2 percent of total body weight, typically receives 12 percent of blood flow from the heart — a level maintained by complex,   Angela Jefferson, Ph.D., director of the Vanderbilt Memory and Alzheimer’s Center, and colleagues investigated whether lower cardiac index

Vanderbilt Reporter feature of Dr. Timothy Hohman's research on resilience

November 10, 2016

Vanderbilt researchers have established a new measure of resilience to cognitive impairment in people with asymptomatic Alzheimer’s disease. They essentially flipped the standard approach used by researchers when mining the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database, said Timothy Hohman, Ph.D., the lead author of the study published online Nov. 4 in Neurology. Instead of assessing factors linked to cognitive decline, they sought to identify participants who maintained cognitive performance.

Vanderbilt Reporter feature of Dr. Timothy Hohman's research exploring African ancestry and it's association with increased risk of Alzheimer's disease

May 2, 2016

Higher genomic levels of African ancestry are associated with an increased risk for Alzheimer’s disease, a consortium of investigators reported recently in Alzheimer’s & Dementia.  It was known that African-Americans are at a higher risk for Alzheimer’s disease, said the study’s first author, Timothy Hohman, Ph.D., assistant professor of Neurology.    

Vanderbilt Reporter feature of Dr. Susan Bell's research on health literacy efforts and reduced readmission rates

March 7, 2016

Vanderbilt University Medical Center and Brigham and Women’s Hospital in Boston recently collaborated on a study analysis to determine the effect of a tailored, pharmacist-delivered health literacy intervention on unplanned hospital readmission or emergency department visit following discharge. Reduction in 30-day readmission rates following hospitalization is a goal at Vanderbilt and hospitals across the country. Each is motivated to keep their readmission rates in check or face receiving less money from Medicare.

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