Memory & Aging Project

Description

The Vanderbilt Memory & Aging Project (MAP) is a longitudinal study investigating vascular health and brain aging. Launched in 2012, the MAP cohort includes 335 community-dwelling participants age 60-92, including 168 individuals with mild cognitive impairment (MCI) and 167 cognitively normal adults. Participants were recruited through postal mailings, clinical referrals, radio advertisements, newsletters, research distribution emails, community events, websites, and word of mouth.

Study procedures

At baseline, participants completed a physical and frailty examination, fasting blood draw, neuropsychological assessment, echocardiogram, cardiac MRI, and brain MRI. A subset underwent 24-hour ambulatory blood pressure monitoring and lumbar puncture for cerebrospinal fluid (CSF) collection.

Relation between vascular health and brain aging

There are several unique features to the Vanderbilt Memory & Aging Project. Detailed baseline assessment of vascular risk factors, systemic vascular health, and cerebrovascular health will present valuable opportunities for longitudinal investigation into the intersection of vascular mechanisms and AD pathology. Baseline storage of DNA, serum, plasma, and CSF samples will facilitate biomarker analyses across the cognitive aging spectrum over time. MAP offers unique opportunities to investigate the emerging intersection of vascular disease and AD on cognitive health.

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Our team

The Memory & Aging Project is run by a multidisciplinary team under the leadership of Angela L. Jefferson, PhD, Director of the Vanderbilt Memory & Alzheimer’s Center and Professor of Neurology at Vanderbilt University. If you are a researcher and you are interested in collaborating with our team, please send us an email with your research interests and ideas for collaboration.

MAP research findings

Acosta LMY, Liu D, Samuels LR, Gifford, KA, Logan LA, Wisniewski K, Wiggins, ME, Libon DJ, Jefferson, AL. (2016, February). Semantic Relatedness in Category Fluency Among Individuals with Mild Cognitive Impairment: The Vanderbilt Memory and Aging Project. Poster presented at the 44th annual meeting of the International Neuropsychological Society in Boston, MA.

Lane EM, Neal J, Liu D, Gifford KA, Hohman TJ, Bell S, Logan LA, Wiggins ME, Wisniewski KM, Niswender KD, Jefferson AL. (2016, February). Insulin Sensitivity, Neuropsychological Performance, and Cognitive Diagnosis: The Vanderbilt Memory & Aging Project. Poster presented at the 44th annual meeting of the International Neuropsychological Society in Boston, MA.

Wiggins ME, Neal J, Liu D, Gifford KA, Hohman TJ, Lane EM, Wisniewski KM, Logan LA, Seabolt C, Martin-Willett R, Dunifon C, Babicz M, Thursby M, Libon DJ, Jefferson AL. (2016, February). Assessing Performance on the Philadelphia (repeatable) Verbal Learning Test in Non-Demented Older Adults: The Vanderbilt Memory & Aging Project. Poster presented at the 44th annual meeting of the International Neuropsychological Society in Boston, MA.

Wisniewski KM, Liu D, Neal JE, Gifford KA, Godfrey M, Logan LA, Samuels LR, Wiggins ME, Libon DJ, Jefferson AL. (2016, February). Psychometric Properties of the Biber Figure Learning Test: The Vanderbilt Memory & Aging Project. Poster presented at the 44th annual meeting of the International Neuropsychological Society in Boston, MA.

Gifford KA, Liu D, Samuels LR, Benson EM, Logan LA, Hohman TJ, Lane EM, Sumner EC, Wisniewski KM, Wiggins ME, Godfrey M, Ruberg FL, Jefferson, AL.  (2015, February). Ambulatory blood pressure variations relate to greater subjective cognitive decline in older adults: The Vanderbilt Memory & Aging Project. Poster presented at the 43rd annual meeting of the International Neuropsychological Society in Denver, CO.

Haj-Hassan S, Liu D, Gifford KA, Libon DJ, Jefferson AJ. (2015, February). Empirically-Derived Subtypes of Mild Cognitive Impairment: The Vanderbilt Memory & Aging Project. Poster presented at the 43rd annual meeting of the International Neuropsychological Society in Denver, CO.

Lane EM, Liu D, Han X, Samuels LR, Benson EM, Logan LA, Gifford KA, Hohman TJ, Sumner EC, Wisniewski KM, Wiggins ME, Godfrey ME, Ruberg FL, Jefferson AL. (2015, February). Abnormal Nocturnal Fluctuations in Ambulatory Blood Pressure Relate to Worse Cognitive Performance in Older Adults: The Vanderbilt Memory & Aging Project. Poster presented at the 43rd annual meeting of the International Neuropsychological Society in Denver, CO.

 

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