Nyman Publications

Selected Publications (since 2016)

  1.  Creecy A, Brown KL, Rose KL, Voziyan P, and JS Nyman. Post-translational modifications in collagen type I of bone in a mouse model of aging. Bone. Online ahead of print.

  2.  Dubrovsky A.M.K, Nyman J.S., Uppuganti S., Chmiel K., Kimmel D.B., and N.E Lane. Bone strength/bone mass discrepancy in glucocorticoid-treated adult mice. JBMR Plus. Online ahead of print.

  3. Thrailkill K.M., Bunn R.C., Uppuganti S., Ray P., Popescu I., Kalaitzoglou E., Fowlkes J.L.,and J.S. Nyman. Canagliflozin, an SGLT2-inhibitor, corrects glycemic dysregulation in TallyHO model of T2D but only partially prevents bone deficits. Bone. 141: 115625, 2020.

  4. Harris D., Garrett K., Uppuganti S., Creecy A., and J.S. Nyman. The BALB/c Mouse as a Preclinical Model of the Age-Related Deterioration in the Lumbar Vertebra. Bone. 137:115438, 2020.

  5. Thrailkill K.M., Bunn R.C., Uppuganti S., Ray P., Garrett K., Popescu I., Pennings J., Fowlkes J.L., and J.S. Nyman. Genetic ablation of SGLT2 function in mice impairs tissue mineral density but does not affect fracture resistance of bone. Bone. 133: 115254, 2020.

  6. Fowlkes J.L., Bunn R.C., Ray P.D., Kalaitzoglou E., Uppuganti S., Unal M., Nyman J.S., and K.M. Thrailkill. Constitutive activation of MEK1 in osteoprogenitors increases strength of bone despite impairing mineralization. Bone. 130: 115106, 2020.

  7. Creecy A., Uppuganti S., Girard M.R., Schlunk S.G., Amah C., Granke M., Unal M., Does M.D., and J.S. Nyman. The Age-Related Decrease in Material Properties of BALB/c Mouse Long Bones Involves Alterations to the Extracellular Matrix. Bone. 130:115126, 2020.

  8. McGough M.A.P., Boller L.A., Groff, D.M., Schoenecker J.G., Nyman J.S., Wenke J.C., Rhodes C., Shimko D., Duvall C.L., and S.A. Guelcher. Nanocrystalline hydroxyapatite-poly(thioketal  urethane) nanocomposites stimulate a combined intramembranous and endochondral ossification response in rabbits. ACS Biomaterials Science & Engineering. 6:564-574, 2020.

  9. Unal M., Uppuganti S., Timur S., Mahadevan-Jansen A., Akkus O., and J.S. Nyman. Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone under review. Scientific Reports. 9:7195, 2019.

  10. Lane N.E., Nyman J.S., Uppuganti S., Chaudhari A.J., Aguirre J.I., Shidara K., Liu X.P., Yao W., and D.B. Kimmel. Inhibition of vascular endothelial growth factor in young adult mice causes low bone blood flow and bone strength with no effect on bone mass in trabecular regions. Bone Reports. In press, 2019.

  11. Yuasa M., Saito M., Blum D.M., Hysong A.A., Egawa S., Uppuganti S., Yoshii T., Okawa A., Schwartz H.S., Moore-Lotridge S.N., Nyman J.S. and J.G. Schoenecker. The Size of Intramedullary Fixation Affects Endochondral Mediated Angiogenesis During Fracture Repair. The Journal of Orthopaedic Trauma. 33:e385-e393, 2019.

  12. Salazar V.S., Capelo L.P., Cantù C., Zimmerli D., Gosalia N., Pregizer S., Cox K., Ohte S., Feigenson M., Gamer L., Nyman J.S., Carey D.J., Economides A., Basler K., Rosen V. Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the periosteal niche in the murine skeleton. eLife. 8:e42386, 2019.

  13. Nyman J.S., Uppuganti S., Unal M., Leverant C.J., Adabala S, Granke M., Voziyan P., and M.D. Does. Manipulating the amount and structure of the organic matrix affects the water compartments of human cortical bone. JBMR Plus. 3(6):e10135, 2019.

  14. Willett, T.L., Dapaah, D.Y., Uppuganti, S. Granke, M. and J.S. Nyman. Bone collagen network integrity and transverse fracture toughness of human cortical bone. Bone. 120:187-193, 2019.

  15. Baker C.E., Moore-Lotridge S.N., Hysong A.A., Posey S.L., Robinette J.P., Blum D., Benvenuti M.A., Cole H.A., Egawa S., Okawa A., Saito M., McCarthy J., Nyman J.S., Yuasa M., and J.G. Schoenecker. Bone fracture acute phase response - A unifying theory of fracture repair: clinical and scientific implications. Clinical Reviews in Bone and Mineral Metabolism. 16:142-158, 2018.

  16. Unal M., Uppuganti S., Leverant C.L., Creecy A., Granke M., Voziyan P., and J.S. Nyman. Assessing glycation-mediated changes in human cortical bone with Raman spectroscopy. Journal of Biophotonics. 11:e201700352 , 2018.

  17. Unal M., Creecy A., and J.S. Nyman. The role of matrix composition in the mechanical behavior of bone. Current Osteoporosis Reports. 16:205-15, 2018.

  18. Creecy A., Uppuganti S., Unal M., Bunn R.C., Voziyan P., and J.S. Nyman. Low bone toughness in the TallyHO model of juvenile type 2 diabetes does not worsen with age. Bone. 110:204-14, 2018.

  19. J.S. Nyman. “Age-Related Changes to Bone Structure and Quality in Rodent Models”. Section V. Organ Systems, Chapter 68, pp. 919-936. In: Conn’s Handbook of Models for Human Aging, 2nd Edition. Eds. J.L. Ram and P.M. Conn. Academic Press. Elsevier. London, UK. 2018.

  20. Sielatycki J.A., Saito M., Yuasa M., Moore-Lotridge S.N., Uppuganti S., Colazo J.M., Hysong A.A., Robinette J.P., Okawa A., Yoshii T., Schwartz H.S., Nyman J.S., and J.G. Schoenecker. Autologous chondrocyte grafting as an alternative to iliac crest in posterolateral spinal fusion. JOR Spine. 1:e1001, 2018.

  21. Makowski A.J., Granke M., Ayala O., Uppuganti S., Mahadevan-Jansen A. and J.S. Nyman. Applying full spectrum analysis in the Raman spectroscopic assessment of fracture toughness of human cortical bone. Applied Spectroscopy. 71:2385-94, 2017

  22. Nyman J.S., Kalaitzoglou E., Bunn R.C., Uppuganti S., Thrailkill K.M., and J.L. Fowlkes. Preserving and restoring bone with continuous insulin infusion therapy in a mouse model of type 1 diabetes. Bone Reports. 7:1-8, 2017.

  23. Thrailkill K.M., Nyman J.S., Bunn R.C., Uppuganti S., Thompson K.L., Lumpkin C.K., Jr., Kalaitzoglou E., and J.L. Fowlkes. The impact of SGLT2 Inhibitors, compared with Insulin, on Diabetic Bone Disease in a mouse model of Type 1 Diabetes. Bone. 94:141-151, 2017.

  24. Manhard M-K., Harkins K.D., Gochberg, D.F., Nyman J.S., and M.D. Does. 30-second bound and pore water concentration mapping of cortical bone using 2D UTE with optimized half-pulses. Magnetic Resonance in Medicine. 77:945-950, 2017.

  25. Manhard M-K., Nyman J.S., and M.D. Does. Advances in imaging approaches to fracture risk evaluation. Translational Research. 181:1-14, 2017.