Functional Overlap of Inborn Errors of Immunity and Metabolism Genes Define T Cell Immunometabolic Vulnerabilities

Patterson, Andrew R., et al. "Functional Overlap of Inborn Errors of Immunity and Metabolism Genes Define T Cell Immunometabolic Vulnerabilities." bioRxiv (2023): 2023-01. (View)

 

IEM IEI Fig 2

 

IEM IEI Fig 4

In vitro and in vivo CRISPR screens used to assay functional drivers of inborn errors of immunity and metabolism identified multiple metabolic mechanisms responsible for defects.