Sugiura, Ayaka, et al. "MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function." Immunity 55.1 (2022): 65-81. (View)
An unbiased in vivo CRISPR screening in primary murine T cells identified MTHFD2 as a hit that was also upregulated consistently in individuals with inflammatory disorders. MTHFD2 deficiency impaired Teff cell proliferation and function.