Filshtein TJ, Brenowitz WD, Mayeda ER, Hohman TJ, Walter S, Jones RN, Elahi FM, Glymour MM. Reserve and Alzheimer's disease genetic risk: Effects on hospitalization and mortality. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2019 Dec;15(15). 907-916. PMID: 31327391 [PubMed] PMCID: PMC7049165
Cognitive reserve predicts delayed diagnosis of Alzheimer's disease (AD) and faster postdiagnosis decline. The net impact of cognitive reserve, combining both prediagnosis and postdiagnosis risk, on adverse AD-related outcomes is unknown. We adopted a novel approach, using AD genetic risk scores (AD-GRS), to evaluate this.