Shaw C, Hayes-Larson E, Glymour MM, Dufouil C, Hohman TJ, Whitmer RA, Kobayashi LC, Brookmeyer R, Mayeda ER. Evaluation of Selective Survival and Sex/Gender Differences in Dementia Incidence Using a Simulation Model. JAMA network open. 2021 Dec 1;4(4). e211001. PMID: 33687445 [PubMed] PMCID: PMC7944377
Dementia research is susceptible to bias arising from selective survival, a process that results in individuals with certain characteristics disproportionately surviving to old age. Spurious associations between risk factors and dementia may be induced when factors associated with longer survival also influence dementia incidence.