Esbenshade AJ, Lu L, Friedman DL, Oeffinger KC, Armstrong GT, Krull KR, Neglia JP, Leisenring WM, Howell R, Partin R, Sketch A, Robison LL, Ness KK. Accumulation of Chronic Disease Among Survivors of Childhood Cancer Predicts Early Mortality. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 May 22. JCO2202240. PMID: 37216619 [PubMed]
Cancer survivors develop cancer and treatment-related morbidities at younger than normal ages and are at risk for early mortality, suggestive of an aging phenotype. The Cumulative Illness Rating Scale for Geriatrics (CIRS-G) is specifically designed to describe the accumulation of comorbidities over time with estimates of severity such as total score (TS) which is a sum of possible conditions weighted by severity. These severity scores can then be used to predict future mortality.