Jacklyn N. Hellwege, PhD
Bachelor of Science in Biology: Pre-Professional, Appalachian State University
Doctor of Philosophy in Molecular Genetics and Genomics, Wake Forest University
My projects focus on genetic association analyses of exome- and genome-wide array data, as well as large-scale sequencing data, for a wide variety of phenotypes, particularly those derived from electronic health records. Phenotypes of particular interest include uterine fibroids, keloid scars, and other fibroproliferative traits, in addition to several collaborative association studies encompassing the broad spectrum of cardiometabolic phenotypes.
My previous work was focused on the integration of two-point linkage analysis with contemporary large-scale genotype information and association analysis to identify high-impact functional variants. Additional methods I employ include gene-based association for low-frequency variants, meta-analysis, interaction analysis (epistasis), and construction of polygenic genetic risk scores. I am particularly interested in genetic research of diseases which disproportionally impact minority health.
Keywords and Content Areas
genetic epidemiology, genomics, uterine fibroids, fibroproliferative, SNP analysis, cardiometabolic, health disparities