José Antonio Diaz, MD, FAHA
Jose Antonio Diaz, MD
Research Associate Professor of Surgery
Director, Division of Surgical Research
Section of Surgical Sciences
José Antonio Diaz, MD, Research Associate Professor of Surgery and Director of the Division of Surgical Research, previously served as a Research Assistant Professor of Vascular Surgery in the Conrad Jobst Vascular Research Laboratories in the Section of Vascular Surgery at the University of Michigan, Ann Arbor, MI. Dr. Diaz is a Vascular Surgeon trained in Cardiovascular and General Surgery with additional specialization in ultrasonography and phlebology. Following his career as a surgeon in Argentina, Dr. Diaz moved to the United States to be trained in basic science research under an NIH T32 training program in Vascular Biology at the University of Michigan.
Dr. Diaz is internationally recognized for his contributions to surgical preclinical model development and vascular disease research. He is interested in surgical research, vascular biology, and immunology, with expertise in deep vein thrombosis, aneurysm, pre-clinical models, and thrombosis. Dr. Diaz is a Board member of the American Venous Forum and the International Society on Thrombosis and Haemostasis. He is also a member of the American Heart Association, the Argentinian College of Venous and Lymphatic Surgery and is an American Venous Forum Distinguished Fellow. He garnered the PVD/ATVB Robert W. Hobson, II, MD Early Career Investigator Award, and became a Fellow of the American Heart Association.
Research
Dr. Diaz’s research interests include surgical research, cardiovascular research, deep vein thrombosis, and transnational pre-clinical models of diseases. He has published articles in Journal of Thrombosis and Haemostasis, Research and Practice in Thrombosis and Haemostasis, Journal of Thrombosis and Haemostasis and Arteriosclerosis, and "Choosing a Mouse Model of Venous Thrombosis", a simultaneous publication in the Journal Thrombosis, and Vascular Biology. This paper is the first consensus in pre-clinical models of venous thrombosis that provided information on model standardization, discussed advantages and disadvantages of each model and included a model selection algorithm that allows investigators and grant reviewers to choose the most appropriate pre-clinical model based on the research question.
Certifications
- Medical Doctor, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina 1992
- General Surgery Specialist, Ministerio de Salud y Acción Social, Buenos Aires, Argentina, 1997
- Phlebology and Lymphology Specialist, Facultad de Posgrado en Ciencias de la Salud, Pontificia Universidad Católica Argentina “Santa María de los Buenos Aires”, Buenos Aires, Argentina, 1998
- Cardiovascular Surgery Specialist, Colegio Argentino de Cirujanos Cardiovasculares, 2002
CONTACT
José Antonio Diaz, MD
Director, Division of Surgical Research
Section of Surgical Sciences
Vanderbilt University Medical Center
CC-2307 Medical Center North
1161 21st Ave. S.
Nashville, TN 37232-2730
Phone (615) 322-3639
EMAIL: jose.a.diaz@vumc.org
Jose Antonio Diaz, MD
Research Associate Professor of Surgery
Director, Division of Surgical Research
Section of Surgical Sciences
El Dr. José Antonio Diaz, Profesor Asociado de Investigación en Cirugía, es el Director de la División de Investigaciones Quirúrgicas de la Universidad de Vanderbilt. Previamente fue Profesor Asistente de Investigación en el Laboratorio de Investigaciones Vasculares de la Universidad de Michigan en Ann Arbor, Michigan. Dr. Diaz es Cirujano Vascular entrenado en Cirugía General y Cirugía Vascular con formación en Ecografía Doppler Vascular Periférica y especialización en Flebolinfología egresado de la Universidad Católica Argentina. Tras finalizar su formación en Cirugía General, Cirugía Vascular y Patología Venosa en Argentina, el Dr. Diaz completó un Fellowship en Biología Vascular en la Universidad de Michigan.
Actualmente, el Dr. Diaz es reconocido internacionalmente por sus contribuciones en el desarrollo y aplicación estratégica de modelos preclínicos para el estudio de enfermedades cardiovasculares, así como por sus investigaciones en biología vascular and inmunología, focalizando su mayor interés en Trombosis Venosa Profunda. Dr. Diaz es miembro del Board of Directors del American Venous Forum y de la Sociedad Internacional de trombosis y Hemostasia. También es miembro del American Heart Association del Colegio Argentino de Cirugía Venosa y Linfática. El Dr. Diaz fue distinguido como Fellow del American Venous Forum y Fellow del American Heart Association y ha sido galardonado con el premio PVD/ATVB Robert W. Hobson, II, MD Early Career Investigator Award del American Heart Association.
Investigación
El Dr. Diaz se ha interesado en Investigaciones Quirúrgicas particularmente Investigaciones Vasculares en el área de Trombosis Venosa Profunda y ha desarrollado un particular interés por el desarrollo de modelos preclínicos. Dr. Diaz tiene publicaciones científicas en Ingles y español incluyendo las guías de selección de modelos preclínicos para estudiar la trombosis venosa profunda en forma experimental. Esta publicación es el primer consensus escrito en el tema y en su contenido versa en ventajas, desventajas y aplicación de cada modelo e incluye un algoritmo que permite elegir el modelo mas apropiado dependiendo del objetivo de la investigación.
Certificación
- Médico, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina 1992
- Especialista en Cirugía General, Ministerio de Salud y Acción Social, Buenos Aires, Argentina, 1997
- Especialista en Frenología y Limnología, Facultad de Posgrado en Ciencias de la Salud, Pontificia Universidad Católica Argentina “Santa María de los Buenos Aires”, Buenos Aires, Argentina, 1998
- Especialista en Cirugía Cardiovascular, Colegio Argentino de Cirujanos Cardiovasculares, 2002
CONTACTO
José Antonio Diaz, MD
Director, Division of Surgical Research
Section of Surgical Sciences
Vanderbilt University Medical Center
CC-2307 Medical Center North
1161 21st Ave. S.
Nashville, TN 37232-2730
Phone (615) 322-3639
EMAIL: jose.a.diaz@vumc.org
Research Information
| SELECTED PUBLICATIONS | |||
| All publications are in English, except for *in Spanish and ** in German. | |||
|
|
|||
| (Venous Disease Research) Invited Article. | |||
| Back To Basics: Theory of Thrombus Formation and Potential Implications for Therapies? | |||
| Tech Vasc Interv Radiol. 2023 Jun;26(2): 100894. PMID: 37865449. | |||
| (Pre-clinical Models) Invited Article. | |||
| Anatomical and Hemodynamic considerations are critical for preclinical models of deep vein thrombosis. | |||
| J Thromb Haemost. 2023 Jul;21(7):1744-1746. PMID: 37330262. | |||
| (Research Priorities) Invited Article. | |||
| Research Priority Documents Leading the Way in Venous Diseases. | |||
| Endovascular Today. Jul 2022. Online. | |||
| (AVF – Meeting Report) Editorial. | |||
| Science Gaps and Future Directions in Venous and Lymphatic Disorders. | |||
| J Vasc Surg Vasc Sci. 2022 Jun 4;3:257-258. PMID: 35846724. | |||
| **(Venous Disease Research) | |||
| The basic scientists are leading the way in understanding, prevention, and treatment of venous and lymphatic diseases. | |||
| Phlebologie. 2022; 51(04): 177-182. | |||
| (AVF – Research Committee - Anticoagulation) | |||
| Extended Anticoagulation for Venous Thromboembolism A Survey of the American Venous Forum and the European Venous Forum. | |||
| J Vasc Surg Venous Lymphat Disord. 2022 May 10:S2213-333X(22)00192-5. PMID: 35561974 | |||
| (Pre-clinical Models) | |||
| Endovascular Today: One Step Forward in Modelling Venous Thrombosis. | |||
| Eur J Vasc Endovasc Surg. 2022 Apr;63(4):631. PMID: 35120816. | |||
| (AVF – Research Committee - Vein Ulcers) | |||
| Review of the current evidence for topical treatment for venous leg ulcers. | |||
| J Vasc Surg - Vasc Science. 2022 Jan;10(1):241-247. PMID: 34171531. | |||
| (DEI -Editorial team, JVS-Vascular Science) Editorial. | |||
| Diversity, equity, and inclusion in JVS-Vascular Science. | |||
| JVS Vasc Sci. 2021 Aug 28;2:179-180. PMID: 34755123. | |||
| (AVF – Meeting Report) Editorial. | |||
| The 2021 American Venous Forum Day of Innovation and Science (Virtual) "Education and scientific writing in venous and lymphatic disease." | |||
| J Vasc Surg – Vasc. Sci. 2021 May 14; 2:70-71. PMID: 34617059. | |||
| (Human Venous Characterization) | |||
| The First - Targeted Gene Expression Analysis of Human Deep Veins. | |||
| J Vasc Surg - Venous Lymphat Disord. 2021 May 9;(3):770-780. PMID: 32860957. | |||
| (Venous Thrombosis) | |||
| Venous Thrombosis Duets: Inflammation/Coagulation, Wall/Flow. | |||
| Blood. 2021 Apr 22;137(16):2137-2138. PMID: 33885707. | |||
| (Venous Diseases) | |||
| Basic Science leading the way for prevention and treatment of varicose veins. | |||
| J Vasc Surg Venous Lymphat Disord. 2021 Jan 9;(1):252-253. PMID: 33339550. | |||
| (Scientific Statement) | |||
| Venous Thrombosis Research Priorities – AHA-ISTH Scientific Statement. | |||
| Circulation. 2020;142(6):e85-e94. PMID: 32776842. | |||
| (Scientific Statement) | |||
| Venous Thrombosis Research Priorities – AHA-ISTH Scientific Statement. | |||
| Res Pract Thromb Haemost. 2020 Jul 8;4(5):714-721. PMID: 32685877. | |||
| (Vascular Surgery) | |||
| Neurological Symptoms of Congenital Portosystemic Shunt Reversed by Venous Endovascular Intervention: A Six Years Follow-Up Study. | |||
| Neuro India. 2020. Jul-Aug 68(4):930-933. PMID: 32859847. | |||
| (Interdisciplinary Team in the Vascular Arena) | |||
| Vascular Surgery and the Multidisciplinary Vascular Research Team. | |||
| J Vasc Surg. 2020 May;8(3):470-471. PMID: 32305117. | |||
| (Vascular Surgery) – Editorial. | |||
| Flexions of the popliteal artery and the culture could challenge the outcomes of the endovascular procedures. | |||
| Ann Vasc Dis. 2020 Mar 25;13(1):1-3.- PMID: 32273915. | |||
| (Preclinical Models) | |||
| Collateral vein dynamics in mouse models of venous thrombosis: Pathways consistent with humans. | |||
| Thromb Res. 2019 Aug 23;182:116-123. PMID: 31476485. | |||
| (Guidelines) | |||
| Global guidelines trends and controversies in lower limb venous and lymphatic disease | |||
| Phlebology. 2019 Sep;34(1_suppl):4-66. PMID: 31495256. | |||
| (Deep Vein Thrombosis) | |||
| Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome. | |||
| Nat Commun. 2019 Apr 23;10(1):1916. PMID: 31015489. | |||
| (Preclinical Models - Guidelines) | |||
| Choosing a Mouse Model of Venous Thrombosis, A consensus assessment of utility and application. | |||
| J Thromb Haemost. 2019 Apr;17(4):699-707. PMID: 30927321. | |||
| -Approved by the American Venous Forum, endorsed by the ISTH and ATVB Council, AHA- | |||
| (Deep Vein Thrombosis-Fibrinolytic System) | |||
| Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate. | |||
| J Biol Chem. 2019 Feb 1;294(5):1464-147. PMID: 30510136. | |||
| (Preclinical Models - Guidelines) | |||
| Choosing a Mouse Model of Venous Thrombosis. | |||
| Arterioscler Thromb Vasc Biol: 2019 Mar;39(3):311-318. PMID: 30786739. | |||
| -Approved by the American Venous Forum, endorsed by the ISTH and ATVB Council, AHA- | |||
| (Deep Vein Thrombosis - Invited commentary) | |||
| Lower limb volume in healthy individuals after walking with compression stockings. | |||
| J Vasc Surg Venous Lymphat Disord. 2019 Jul;7(4):557-561. PMID: 30922985. | |||
| (Preclinical Models) | |||
| Update on the electrolytic IVC model for preclinical studies of Venous Thrombosis. | |||
| Res Pract Thromb Haemost. 2018 Jan 31;2(2):266-273. PMID: 30046728. | |||
| (Deep Vein Thrombosis - Invited commentary) | |||
| Give me a Narrowing in the Venous System, and I Shall Stent it. | |||
| Eur J Vasc Endovasc Surg: 2018 Aug:56(2):255. PMID: 30100018. | |||
| (Recurrent Deep Vein Thrombosis) | |||
| Pre-clinical Model to Study Recurrent Venous Thrombosis in the Inferior Vena Cava. | |||
| Thromb Haemost. 2018 Apr 25. [Epub ahead of print]. PMID: 29695021. | |||
| (Preclinical Models – Deep Vein Thrombosis) | |||
| Statins in Venous Thrombosis: More Evidence, More Basic Science Findings. | |||
| J Investig Med. 2018 Feb;66(2):e3. PMID: 29018049 | |||
| (Deep Vein Thrombosis - Proteomics) | |||
| Deep vein thrombosis exhibits characteristic serum and vein Wall metabolic phenotypes in the inferior vena cava ligation mouse model. | |||
| Eur J Vasc Endovasc Surg. 2018 May;55(5):703-713. PMID: 29526653. | |||
| (Vein Flow: Physics) | |||
| Hemodynamics of venous valve pairing and implications on helical flow. | |||
| J Vasc Surg Venous Lymphat Disord. 2018 Jul;6(4):517-522. PMID: 29909857. | |||
| (Cancer-Associated Thrombosis) | |||
| Galectin-3 In Venous Thrombosis: A Possible New Target for Improved Patient Care. | |||
| Res Pract Thromb Haemost. 2018;2(2),399-400. PMID 30046744. | |||
| (Biomarkers and Deep Vein Thrombosis) | |||
| Venous Thrombosis and Post-Thrombotic Syndrome: From Novel Biomarkers to Biology. | |||
| Methodist Debakey Cardiovasc. J. 2018 Jul-Sep;14(3):173- 181. PMID: 30410646. | |||
| (Deep Vein Thrombosis) | |||
| Statins in Venous Thrombosis: More Evidence, More Basic Science Findings. | |||
| J Investig Med. 2017 Oct 9. [Epub ahead of print]. PMID: 29018049. | |||
| (Vascular Biology - Invited commentary) | |||
| Uncovering the genesis of varicose veins should consider both vein wall biology and flow dynamics for a complete picture. | |||
| J Vasc Surg: Venous and Lym Dis. 2017 Sep;5(5)734. PMID: 28818229. | |||
| (Vascular Surgery) | |||
| Dynamic Classification of the Popliteal Artery. | |||
| RE: "Endovascular treatment of the atherosclerotic popliteal artery disease based on dynamic angiography findings". | |||
| J Vasc Surg 2017, Mar;65(3):932-933. PMID: 28236937. | |||
| (Deep Vein Thrombosis) | |||
| Effectiveness of Infrared Thermography in the Diagnosis of Deep Vein Thrombosis: An Evidence-based review. | |||
| J Vasc Diag Int. 2017 Feb;5:7-14. (Invited Manuscript). | |||
| (Preclinical Models - Invited commentary) | |||
| Animal Models of Venous Thrombosis: To change or not to change? | |||
| Blood. 2015, Nov 5, 126: 2177-2178. PMID: 26542254. | |||
| *(Vascular Surgery) | |||
| *Changes in popliteal artery during flexion of the knee. Diagnosis and therapeutic value. | |||
| Revista Argentina de Cardioangiología Intervencionista (Journal of the Argentinian College of interventional Cardiologist), 2015;6(3):135-141; ISSN2313-9307. | |||
| *(Vascular Surgery) | |||
| *Pulmonary artery embolization for treatment of massive hemoptysis. | |||
| Revista Argentina de Cardioangiología Intervencionista (Journal of the Argentinian College of interventional Cardiologist), 2015;6(1):33-41; ISSN2313-9307. Commentaries. | |||
| (Vascular Biology and Deep Vein Thrombosis) | |||
| Inferior Vena Cava (IVC) Branch Variations in C57BL/6 Mice Impact Thrombus Size in IVC Ligation (Stasis) Model. | |||
| J Thromb Haemost. 2015 Apr;13(4):660-45. PMID: 25683196. | |||
| (Vascular Biology and Deep Vein Thrombosis) | |||
| P-Selectin Inhibition Therapeutically Promotes Thrombus Resolution and Prevents Vein Wall Fibrosis Better Than Enoxaparin and an Inhibitor to von Willebrand Factor. | |||
| Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):829-37. PMID: 25657307. | |||
| (Vascular Biology and Deep Vein Thrombosis) | |||
| The role of galectin-3 and galectin-3-binding protein in venous thrombosis. | |||
| Blood. 2015 Mar 12;125(11):1813-21. pii: blood-2014-04-569939. [Epub ahead of print]. PMID: 25428218. | |||
| (Preclinical Models) | |||
| The Electrolytic Inferior Vena Cava Model (EIM) to study thrombogenesis and thrombus resolution with continuous blood flow in the mouse. | |||
| Thromb Haemost. 2013 Jun;109(6):1158-69. PMID: 23571406. | |||
| (Biomarkers and Deep Vein Thrombosis) | |||
| Plasma DNA is Elevated in Patients with Deep Vein Thrombosis. | |||
| J Vasc Surg: Venous and Lym Dis 2013;1(4):341-8. PMID: 24187669. | |||
| *(Vascular Surgery) | |||
| *Percutaneous treatment of hemoptisis: Anatomy, pathophisiology, new techniques, prevention of complications. | |||
| Revista Argentina de Cardioangiología Intervensionista (Journal of the Argentinian College of interventional Cardiologist), 2013 Mar;4(1):40-48. ISSN 2313-9307 | |||
| (Vascular Biology and Deep Vein Thrombosis) | |||
| Rosuvastatin reduced deep vein thrombosis in ApoE gene deleted mice with hyperlipidemia through non-lipid lowering effects. | |||
| Thromb Res. 2013 Mar;131(3):268-76 PMID: 23276528. | |||
| (Vascular Surgery) | |||
| Endovascular Treatment of an Aortoiliac Tuberculous Pseudo-aneurysm. | |||
| Cardiovasc Intervent Radiol. 2012 May 24. PMID 22623144. | |||
| (Preclinical Models) | |||
| A Critical Review of Mouse Models of Venous Thrombosis. | |||
| Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):556-62. PMID: 22345593. | |||
| (Vascular Biology and Deep Vein Thrombosis) | |||
| Statins, Inflammation and Deep Vein Thrombosis: A Systematic Review. | |||
| J Thromb Thrombolysis. 2012 May;33(4):371-82. PMID: 22278047. Invited review article. | |||
| (Vascular Biology and Deep Vein Thrombosis) | |||
| Impaired fibrinolytic system in ApoE null mice with hyperlipidemia augments deep vein thrombosis. | |||
| J Vasc Surg. 2012 Mar;55(3):815-22. Epub 2011 Nov 25. PMID: 22119245. | |||
| (Vascular Biology and Deep Vein Thrombosis) | |||
| Physical Characterization of Mouse Deep Vein Thrombosis Derived Microparticles by Differential Filtration with Nanopore Filters. | |||
| Membranes (Basel). 2011 Dec;27(1):1-15. PMID: 24957960. | |||
| (Vascular Surgery) | |||
| Flexions of the Popliteal Artery: Technical considerations of the femoropopliteal stenting. | |||
| J Invasive Cardiol. 2011 Oct;23(10):431-3. PMID: 21972163. | |||
| (Preclinical Models) | |||
| Electrolytic Inferior Vena Cava Model (EIM) of Venous Thrombosis. | |||
| J Vis Exp. 2011 Jul 12;(53):e2737. doi: 10.3791/2737. PMID: 21775963. | |||
| (Vascular Biology and Deep Vein Thrombosis) | |||
| Interleukin-6: A Potential Target for Post-thrombotic Syndrome. | |||
| Ann Vasc Surg. 2011 Feb;25(2):229-39. Epub 2010 Dec 4. PMID: 21131172. | |||
| (Immunology) | |||
| Emerging Fungal Infections. Invited Article. | |||
| Lancet Infect Dis, 2011 Feb;11(2):142-51. PMID: 21272794. | |||
| (Vascular Biology and Deep Vein Thrombosis) | |||
| Inflammation and acute vein thrombosis. | |||
| US Oncology & Hematology 2011;7(1):68–71. Invited review article. | |||
| (Preclinical Models) | |||
| Thrombogenesis with continuous blood flow in the inferior vena cava: a novel mouse model. | |||
| Thromb Haemost. 2010 Aug;104(2):366-75. Epub 2010 Jun 29. PMID: 20589322, PMCID: PMC3065022. | |||
| (Vascular Biology and Deep Vein Thrombosis) | |||
| Do Galectins Play a Role in Venous Thrombosis? A Review. | |||
| Thromb Res. 2010 May;125(5):373-6. Epub 2009 Dec 2. Invited Article. PMID: 19959209, PMCID: PMC2860062. | |||
| (Immunology and Cardiac Transplantation) | |||
| Critical role of IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection. | |||
| Am J Transplant. 2009. Aug;9(8):1773-83. PMID: 19538487, PMCID: PMC2756490. | |||
| (Vascular Surgery) | |||
| Pulmonary artery access embolization in patients with massive hemoptysis in whom bronchial and/or non-bronchial systemic artery embolization is contraindicated. | |||
| Cardiovasc Intervent Radiol. 2008 May-Jun;31(3):633-7. PMID: 18175175. | |||
| (Vascular Surgery) | |||
| Delayed manifestation of abdominal aortic stenosis in a child presenting 10 years after blunt abdominal trauma. | |||
| J Vasc Surg. 2006 Nov;44(5):1104-6. PMID: 17098550. | |||
| (Vascular Surgery) | |||
| Retrograde Rotablator in Limb Salvage: A new technique using a distal open approach. | |||
| Cardiovasc Intervent Radiol. 2006 Sep-Oct;29(5):854-6. PMID: 16802076. | |||
| (Vascular Surgery) | |||
| Dynamic Anatomy of the Popliteal Artery: Might Culture Affect the Outcome of Endovascular Therapy? | |||
| J Endovasc Ther. 2005 Oct;12(5):623-5. PMID: 16212467. | |||
| (Vascular Surgery) | |||
| Endovascular Treatment of a Stenosed Anomalous Left Gastric Artery: Unique Open Artery of the Gastrointestinal Tract. | |||
| J Invasive Cardiol. 2005 Mar;17(3):197-8. PMID: 15867460. | |||
| (Cancer and Deep Vein Thrombosis) | |||
| Diagnosis of Deep Septic Thrombophlebitis in cancer patients by Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography Scanning: a Preliminary Report. | |||
| J Clin Oncol. 2004 May 15; 22(10):1949-56. PMID: 15143089. | |||
| (Vascular Surgery) | |||
| Flexions of the Popliteal Artery: Dynamic Angiography. | |||
| J Invasive Cardiol, 2004 Dec;16(12):712-5. PMID: 15596876. | |||
| NDM |