Optimization of Optical Parameters for Improved Photodynamic Therapy of Staphylococcus aureus Using Endogenous Coproporphyrin III.

It has recently been shown that endogenous photosensitization of Gram-positive bacteria is achieved through the accumulation of the heme precursor coproporphyrin III and not protoporphyrin IX, as was previously assumed. As previous studies have operated under this assumption, the efficacy of optimal targeting of the absorption peaks of coproporphyrin III has not been explored.