Bohannon JK, Cui W, Toliver-Kinsky T. Endogenous Fms-like tyrosine kinase-3 ligand levels are not altered in mice after a severe burn and infection. BMC immunology. 2009 Aug 28;10(10). 47 p. PMID: 19715582 [PubMed] PMCID: PMC2744912
Fms-like tyrosine kinase-3 ligand (Flt3L) is a hemopoietic cytokine and dendritic cell (DC) growth factor that promotes the proliferation and differentiation of progenitor cells into DCs. We have previously found that treatment of severely burned mice with recombinant Flt3L significantly enhances DC production and bacterial clearance from infected burn wounds, and increases global immune cell activation and survival in response to a burn wound infection. These significant benefits of Flt3L treatment after burn injury have prompted the question of whether or not severe burn injury induces deficits in endogenous Flt3L levels that could affect DCs and subsequent responses to infection.