Title: PO Versus IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation
Funded by Department of Defense ( ), PI: Obremskey, Vanderbilt University Medical Center
Funded by Department of Defense (W81XWH-21-1-0273), PI: Noehren, University of KY, Site PI: Archer, Vanderbilt University Medical Center
Lower extremity traumatic fractures are one of the largest medical burdens in the United States military, costing almost $2 billion annually and resulting in the highest percentage of days on limited duty. These injuries result in long-term limitations in physical function which directly contribute to reduced Department of Defense (DoD) operational readiness. Consequently, there is an unmet need to optimize post-operative rehabilitation strategies, in order to more effectively and efficiently restore the injured service members physical function. To address this unmet clinical need, this pilot clinical trial will assess a novel high intensity interval training (HIIT) neurorehabilitative speed walking program during the early period of recovery to improve return to work, functional abilities, and psychosocial recovery following a long bone fracture. Results will be a clinically deployable treatment for patients after lower extremity trauma to maximize recovery and their physical ability to reintegrate to operational readiness.
Title: Improving Recovery after Orthopaedic Trauma: Cognitive-Behavioral Based Physical Therapy (CBPT)
Funded by Department of Defense (W81XWH-16-2-0060), PI: Archer, Vanderbilt University Medical Center
Each year, millions survive traumatic injuries and as a result are faced with life altering outcomes. Over 2.5 million individuals are hospitalized each year due to traumatic injuries. In addition, an analysis of over 16 million traumatic injury discharges from US hospitals between 2000 and 2011 revealed that majority were due to extremity fractures. The financial burden on the US health care system due to trauma is substantial accounting for over $55 billion in lifetime direct and indirect costs for civilians. Physical and psychological impairments resulting from traumatic injuries are often significant and impact employment and functional independence for the 40 to 50 years of remaining life.
This multi-center randomized controlled trial is a collaboration between Vanderbilt University Medical Center and the Major Extremity Trauma Rehabilitation Research Consortium to determine the efficacy of a psychologically informed rehabilitation program in service members and civilians following traumatic lower-extremity injury. This study aims to improve physical function outcomes and help patients return to normal activities. (https://clinicaltrials.gov/ct2/show/NCT03335657)
Funded by Department of Defense (W81XWH-16-2-0061), PI: Archer, Vanderbilt University Medical Center
Resiliency (i.e., the process of negotiating, managing, and adapting to a traumatic event) is an important concept that has received little attention in both the civilian and military orthopaedic trauma literature. Individuals with high resiliency are more likely to positively adapt when recovering from trauma. Therefore, it is critical that rehabilitation specialists identify individuals with low resiliency in order to improve outcomes after lower-extremity injury.
This prospective cohort study aims to develop and test a resiliency instrument that is relevant to active duty Service Members. This instrument has the potential to help physical therapists and other health care providers identify Service Members who could benefit from additional skills associated with resiliency (social skills, problem-solving, relaxation, positive coping).
Title: Improving Outcomes after Traumatic Injury: A Goal Management Approach (GMT)
Funded by National Institute on Disability, Independent Living, and Rehabilitation Research (H133G120052), PI: Archer, Vanderbilt University Medical Center
The Center for Disease Control and Prevention (CDC) estimates that traumatic brain injury (TBI) accounts for over 2.5 million emergency room visits, hospitalizations, and deaths. Cognitive rehabilitation, and more specifically Goal Management Training (GMT), has proven effective for patients with TBI. However, many patients with mild TBI go unidentified and experience prolonged and profound physical and psychosocial disability.
This three group randomized controlled trial examined the effect of a telephone-based GMT program in trauma survivors with mild TBI. Patients were followed for 7 months after hospital discharge to assess cognitive functioning, functional status, and psychological health. (https://clinicaltrials.gov/ct2/show/NCT01714531)
Funded by Department Of Defense (W81XWH-18-1-0810), PI: Obremskey, Vanderbilt University Medical Center
Ankle fractures are common in the military's adult population and there is no consensus regarding the optimal time to weight bear after surgery. This two group randomized controlled trial (RCT) is comparing the effect of early and delayed weight bearing in patients with operatively treated ankle fractures. A smaller pilot RCT will be conducted alongside the larger definitive trial to determine the impact of early and delayed weight bearing in patients surgically treated for unicondylar plateau fractures. Patients will be followed for 12 months following definitive fracture fixation. The study will be conducted in collaboration with the Major Extremity Trauma and Rehabilitation Consortium (METRC) and its Coordinating Center at Johns Hopkins. Participants will be recruited from up to 16 civilian Level I trauma centers across the United States. (https://clinicaltrials.gov/ct2/show/NCT04028414)