Laboratory Summary: Research in the Karijolich lab is focused on the molecular biology of oncogenic viruses, in particular the human gammaherpesviruses Kaposi’s sarcoma-associated herpesvirus and Epstein-Barr Virus. Our work is directed at the intersection of host-virus interactions and nucleic acid biology. Current areas of investigation are: 1) Defining the regulation of nucleic acid sensing during infection and oncogenesis, 2) Transcriptional regulation on viral genomes and the immune responses to them, and 3) Structural genomics and epigenomics of viral genome maintenance. Our work is multidisciplinary and combines virology, immunology, RNA biochemistry, and high-throughput sequencing and proteomic approaches.
The lab is within the Division of Molecular Pathogenesis in the Department of Pathology, Microbiology, and Immunology at Vanderbilt University School of Medicine. We are also affiliated with the Vanderbilt-Ingram Cancer Center.