1. Denton, J., Boahene, D., Moran, W.M. Luminal L-alanine stimulates exocytosis at the K+-conductive apical membrane of Aplysia enterocytes.  Am J Physiol – Cell Physiol. 275: C1300-12, 1998 PMID: 9814979

2. Chalfant, M.L., Denton, J., Langloh, A.L., Karlson, K.H., Loffing, J., Benos, D.J., Stanton, B.A.  The NH2 terminus of the epithelial sodium channel contains an endocytic motif.  J Biol Chem. 274: 32889-96, 1999 PMID: 10551853

3. Chalfant, M.L., Denton, J., Berdiev, B.K., Ismailov, I.I., Benos, D.J., and Stanton, B.A. Intracellular H+ regulates the -subunit of ENaC, the epithelial Na+ channel.  Am J Physiol - Cell Physiol. 276:C477-86, 1999 PMID: 9950776

4. Moyer, B.D., Denton, J., Karlson, K.H., Reynolds, D., Wang, S., Mickle, J.E., Milewski, M., Cutting, G.R., Guggino, W.B., Li, M., Stanton, B.A.  A PDZ-interacting domain in CFTR is an apical membrane polarization signal.  J Clin Invest. 104:1353-61, 1999 PMID: 10562297

5. Moran, W.M., Denton, J., Wison, K., Williams, M., Runge, S.W.  A simple, inexpensive method for teaching how membrane potentials are generated.  Am J Physiol - Education. 277, S51-59, 1999 PMID: 10644260

6. Moyer, B.D., Duhaime, M., Shaw, C., Denton, J., Reynolds, D., Karlson, K.H., Pfeiffer, J., Wang, S., Mickle, J.E., Milewski, M., Cutting, G.R., Guggino, W.B., Li, M., Stanton, B.A.  The PDZ-interacting domain of cystic fibrosis transmembrane conductance regulator Is required for functional expression in the apical plasma membrane.  J Biol Chem. 275:  27069-74, 2000 PMID: 10852925

7. Denton, J. and Leiter, J. C. Anomalous effects of external TEA on permeation and gating of the transient A-type potassium current in Helix aspersa neuronal somata. J Mem Biol. 190: 17-28, 2002 PMID: 12422269

8. Rutledge, E., Denton, J., and Strange, K.  Cell cycle- and swelling-induced activation of a C. elegans ClC channel is mediated by CeGlC-7a/b phosphatases.  J Cell Biol. 158: 435-44, 2002 PMID: 12163466

9. Denton, J., Nehrke, K. Rutledge, E., Morrison, R., Strange, K.  Alternative splicing of N- and C-termini of a C. elegans ClC channel alters gating and sensitivity to extracellular Cl- and H+. J Physiol.  555, 97-114, 2004 PMID: 14565992

10. Denton, J., Nehrke, K., Yin, X., Morrison, R., and Strange, K.  GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel.  J Gen Physiol. 125: 113-25, 2005 PMID: 15684092 *Cover article,   **Selected for “Highlights from the Literature”, Physiology. 

11. Strange, K., Denton, J., Nehrke.  Ste20-type kinases: evolutionarily conserved regulators of ion transport and cell volume. Physiol. 21, 61-68, 2006 PMID: 16443823

12. Denton, J., Nehrke, K., Yin, X., Beld, A.M., Strange, K.  Altered gating and regulation of a carboxy-terminus ClC channel mutant expressed in the C. elegans oocyte. Am J Physiol – Cell Physiol.  290: C1109-18, 2006 PMID: 16306126

13. He, L., Denton, J., Nehrke, K., Strange, K.  Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity.  Biophys. J.  90: 3570-81, 2006 PMID: 16500974

14. Yin, X., Denton, J., Yan, X., Strange, K.  Characterization of a novel voltage-dependent outwardly rectifying anion current in C. elegans oocytes.  Am J Physiol – Cell Physiol.  292:  C269-77, 2007 PMID: 16899547

15. Chernow M.M., Daubenspeck J.A., Denton J., Pfeiffer J.R., Putnam R.W., Leiter J.C.  A computational analysis of central CO2 chemosensitivity in Helix aspersa.  Am J Physiol. – Cell Physiol.  292: C278-91, 2007 PMID: 16928773

16. Denton, J., McCann, F.V., Leiter, J.C.  CO2 chemosensitivity in Helix aspersa: Three potassium currents mediate pH-sensitive neuronal spike timing.  Am J Physiol – Cell Physiol.  292:  C292-04, 2007 PMID: 16928774

17. Nehrke, K., Denton, J., Mowry, W., Intestinal Ca2+ wave dynamics in freely moving C. elegans coordinate a rhythmic motor program, Am J Physiol – Cell Physiol. 294:  C333-44, 2008 PMID: 17942636

18. Fallen, K., Banerjee, S., Sheehan, J., Addison, D. Lewis, L.M., Meiler, J., Denton, J.S. The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating.  Channels, 3(1): 57-68, 2009 PMID: 19221509

19. Lewis, L.M., Bhave, G., Chauder, B.A., Banerjee, S., Lornsen, K.A., Redha, R., Fallen, K., Lindsley, C.W., Weaver, C.D., Denton, J.S.  High-throughput screening reveals a novel antagonist of ROMK and Kir7.1.  Mol Pharm. 76(5): 1094-1103, 2009 PMID: 19706730     

20. Bhave, G., Lonergan, D., Chauder, B.A. and Denton, J.S.  Small-molecule modulators of inward rectifying potassium channels:  recent advances and future possibilities.  Future Med Chem. 2(5), 757-774, 2010 PMID: 20543968

21. Bhave, G., Chauder, B.A, Kadakia, R., Liu, W., Dawson, E.S., Nguyen, T.T., Meiler, J., Weaver, C.D., Satlin, L.M., Lindsley, C.W., Denton, J.S., Development of a Selective Small-Molecule Inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel,  Mol Pharm. 79:42–50, 2011 PMID: 20926757      

22. Raphemot R, Lonergan D.F, Nguyen T.T., Utley T., Lewis L.M., Kadakia R., Weaver C.D., Gogliotti R., Hopkins C., Lindsley C.W., Denton J.S. Discovery, characterization, and structure-activity relationships of a small-molecule inhibitor of inward rectifier potassium channels with preference for Kir2.3, Kir3.X and Kir7.1.

Front Pharm., 2:75 2011 PMID: 22275899      **Selected for Commentary in Frontiers in Pharmacology

23. Denton, J.S. and Jacobson, D.A. Channeling dysglycemia: ion channel polymorphisms perturbing glucose homeostasis. Trends in Endocrinology and Metabolism, 23:41-488, 2012. PMID: 22134088

24. Raphemot, R., Weaver, C.D., Denton, J.S. High-throughput screening for small-molecule modulators of inward rectifier potassium channels. J Vis Exp, 71, 2013.

25. Raphemot, R., Rouhier M.F., Hopkins, C.R., Gogliotti, R.D., Lovell, K.M.,. Hine, R.M., Ghosalkar, D., Longo, A., Beyenbach,K.W., Denton, J.S., Piermarini, P.M.  Eliciting renal failure in mosquitoes with a small-molecule inhibitor of inward-rectifier potassium channels. PLoS One, 8:5, 2013, PMID: 23734226

26. Kaufmann, K., Romaine, I.; Days, E., Pascual, C., Malik, A., Yang, L., Zou, B., Du,Y., Sliwoski, G., Morrison, R., Denton, J.S., Niswender, C., Daniels, J.S., Sulikowski, G., Xie, X.; Lindsley, C., Weaver, C. D. VU0456810 (ML297), the first potent and selective activator of the GIRK potassium channel, displays anti-epileptic properties in mice. ACS Chem Neurosci., 18;4(9):1278-86, 2013. PMID: 23730969

27. Denton, J.S., Pao, A., Madduke, M. Invited Review: Novel diuretic targets. Am J Physiol – Renal Physiol. 305(7): F931-942, 2013, PMID: 23863472

28. Bruehl, S., Denton, J.S.., Lonergan, D., Koran, M.E., Chont, M., Sobey, C., Fernando, S., Bush, W.S., Mishra, P., and Thornton-Wells, T.A, Polymorphisms in GIRK1 and GIRK2 genes may impact on chronic pain risk, intensity, and disability, Pain, 154(12), 2853-28539, 2013, PMID 23994450

29. Raphemot, R., Kadakia, R.J., Olsen, M., Banerjee, S., Days, E., Smith, S.S., Weaver, C.D., Denton, J.S. Development and validation of fluorescence- and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1. Assay and Drug Development Technologies 11, 532-543, 2013 *Cover article PMID: 24266659

30. Swale, D., Kharade, S., Denton, J.S. Inward rectifier potassium channels in renal and cardiovascular diseases. Current Opinion in Pharmacology, 15:7-15 2014, PMID 24721648

31. Denton, J.S. Druggability of the inward rectifier family: Hope for rare channelopathies? Invited editorial, Future Med Chem, 6(9): 971-973, 2014. PMID: 24547691

32. Raphemot, R., Swale, D.R., Dadi, P.K., Jacobson, D.A., Cooper, P., Banerjee, S., Nichols, C., Denton, J.S. Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol Pharm. 85:858-65, 2014, PMID: 24646456

33. Raphemot, R.., Estévez-Lao, T.Y., Rouhier, M.F., Piermarini, P.M., Denton, J.S., Hillyer, J.F. Molecular and functional characterization of Anopheles gambiae inward rectifier potassium (Kir1) channels: A novel role in egg production. Insect Biochem and Mol Biol. 51:10-9 PMID: 24855023

34. Rouhier, M, Raphemot, R, Denton, J.S., Piermarini, P.M., Pharmacological validation of an inward-rectifier potassium (Kir) channel as an insecticide target in the yellow fever mosquito Aedes aegypti. PLoS One 24;9(6) PMID: 24959745

35. Rouhier, M., Hine, R., Raphemot, R., Denton, J.S., Piermarini, P., Beyenbach, K. The excretion of NaCl and KCl loads in mosquitoes: 2. Effects of the small molecule Kir channel inhibitor VU573 and its inactive analog VU342. Am J Physiol. – Regulatory and Integrative Physiol. 307(7): 850-861, 2014. PMID: 25056106

36. McCloskey, C. Rada, C., Bailey, E., McCavera, S., van den Berg, H.A., Atia, J., Rand, D.A., Shmygol, A., Chan, Y.-W., Quenby, S., Brosens, J.J., Vatish, M., Zhang, J., Denton, J.S., Taggart, M.J., Kettleborough, C., Tickle, D., Jerman, J., Wright, P., Dale, T., Kanumilli, S., Trezise, D.J., Thornton, S., Brown, P., Catalano, R., Lin, N., England, S.K., Blanks, S.K. The inwardly rectifying K+ channel Kir7.1 controls uterine excitability throughout pregnancy. EMBO Mol Med 23(6): 1161-74, 2014, PMID: 25056913

37. Raphemot, R., Royhier, M.F., Swale, D.R., Days, E., Weaver, C.D., Lovell, K.M., Konkel, L.C., Enger, D.W., Bollinger, S.F., Hopkins, C., Piermarini, P.M., Denton, J.S. Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels. PLoS One. 9(11), 2014. PMID: 25375326

38. Ghamari-Langroudi, M., Digby, G.J., Sebag, J.A., Millhauser, G.L., Palomino, R., Matthews, R., Gillyard, T., Tough, I.R., Cox, H.M., Denton, J.S., Cone, R.D. -MSD and AgRP are G-protein independent diametric agonists of Kir channel function in hypothalamic neurons. Nature 520: 94-8. 2015. PMID: 25600267

39. Swale, D.R., Sheehan, J.H., Banerjee, S., Husni, A.S., Nguyen, T.T., Meiler, J., Denton, J.S. Computational and functional analyses of a small-molecule binding site in ROMK. Biophys J. 108(5), 2015. PMID: 25762321

40. Kharade, S.V., Swale, D.R., Denton, J.S. ROMK (Kir1.1) pharmacology comes of age. Channels, 2015.  PMID: 25941772

41. Piermarini, P.M., Raphemot, R.R., Denton, J.S., Hine, R., Beyenbach, K. Localization and role of inward rectifier K+ channels in Malpighian tubules of the yellow fever mosquito Aedes aegypti. Insect Biochemistry and Molecular Biology, 2015 PMID: 26079629

42. Beyenbach, K., Yu, Y., Piermarini, P.M., Denton, J.S. Targeting renal epithelial channels for the control of insects. Tissue Barriers. 3(4), 2015. PMID: 26716074.

43. Herington, J.L., Swale, D.R., Brown, N., Williams, C.H., Hong, C.C., Paria, B.C., Denton, J.S., Reese, J. High-throughput screening of myometrial calcium-mobilization to identify modulators of uterine contraction. PLoS One. 10(11), 2015. PMID: 266000013

44. Kharade, S.V., Flores, D., Byers, F.W., Morrison, R.D., Daniels, S., Lindsley, C.W., Satlin, L.M., Denton, J.S. ROMK Inhibitor Actions in the Kidney Probed with Diuretics. Am J Physiol – Renal Physiol. Epub Dec. 9th, 2015. PMCID: PMC4835929. 

45. Kharade, S.V., Nichols, C., Denton, J.S. The shifting landscape of KATP channelopathies and need for sharper therapeutics. Future Med Chem. 8(7): 789-802, 2016 PMID: 27161588

46. Daniel R. Swale, Haruto Kurata, Sujay V. Kharade, Jonathan Sheehan, Rene R. Raphemot, Karl R. Voigtritter, Eric Figueroa, Jens Meiler, Anna L. Blobaum, Craig W. Lindsley, Corey R. Hopkins, Jerod S. Denton. ML418: The first selective, sub-micromolar pore blocker of Kir7.1 potassium channels. ACS Chem Neurosci. 7(7): 1013-23, 2016. PMID: 27184474

47. Gregory M. Martin, Emily Rex, Prasanna Devaraneni, Jerod S. Denton, Kara E. Boodhansingh, Diva DeLeon, Charles A. Stanley, Show-Ling Shyng, Pharmacological Correction of Trafficking Defects in ATP-Sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations. J Biol Chem. 291(42): 21971-21983, 2016. PMID: 27573238

48. Swale, D.R., Rouhier, M.F., Gross, A., Days, E., Bloomquist, J.R., Hopkins, C., Piermarini, P.M., Denton, J.S. Discovery of a small-molecule inhibitor of inward rectifier potassium channels with resistance-breaking, mosquitocidal activity. Scientific Reports. 6:36954, 2016. PMID: 27849039

49. Zhongxia Yang, Bethanie-Michelle Statler, Travis L. Calkins, Edna Alfaro, Carlos J. Esquivel, Matthew F. Rouhier, Jerod S. Denton, and Peter M. Piermarini. Dynamic expression of genes encoding subunits of inward rectifier potassium (Kir) channels in the yellow fever mosquito Aedes aegypti. Comparative Biochemistry and Physiology: part B. 204: 35-44, 2017. PMID: 27836744

50. Piermarini, PM, Esquivel, CJ, Denton, JS. Malpighian tubules as novel targets for mosquito control. Int J Environ Res Public Health. 14(2), 2017. PMID: 28125032

51. Kharade, SV, Figueroa, E, Sheehan, J, Meiler, J, Denton, JS. Pore polarity and charge determine differential block of Kir1.1 and Kir7.1 potassium channels by the small-molecule inhibitor VU590. Mol Pharm, 92(3): 338-346, 2017. PMID 28619748

52. Denton, JS and Kharade, SV. Plight of the pore polar bar(rier). Channels. 2017. PMID: 28806132. 

53. Shahi, P., Liu, X, Aul, B., Moyer, A., Pattnaik, A., Denton, JS, Pillers, DA, Pattnaik, B. Abnormal Electroretinogram after Kir7.1 Channel Suppression Suggests Role in Retinal Electrophysiology. Sci Reports. 7(1): 10651, 2017. PMID: 28878288

54. Sammons MF, Kharade SV, Filipski KJ, Boehm M, Smith AC, Shavnya A, Fernando DP, Dowling MS, Carpino PA, Castle NA, Zellmer SG, Antonio BM, Gosset JR, Carlo A, Denton JS. Discovery and in vitro optimization of 3-sulfamoylbenzamides as ROMK inhibitors. ACS Med Chem Lett. 19; 9(2): 125-130, 2018. PMID: 29456800

55. Kharade, SV, Kurata, H., Bender, AM, Blobaum, AL, Figueroa, E, Duran, A, Kramer, M, Days, E, Paige, P, Flores, D, Satlin, LM, Meiler, J, Weaver, CD, Lindsley, CW, Hopkins, CR, Denton, JS. Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992. Mol Pharmacol, 94(2): 926-937, 2018. PMID: 29895592.

Book Chapter

Kharade, S.V. and Denton, J.S. Small-molecule pharmacology of epithelial inward rectifier potassium channels. Ion channels and transporters of epithelia in health and disease. American Physiological Society/Springer, 2016. 

Shelton, E.L. and Denton, J.S. Molecular, genetic, and pharmacological modulation of the ductus arteriosus: KATP channels as novel drug targets. In: Etiology and Morphogenesis of Congenital Heart Disease. Springer. 2018