Tuberculosis

Active Grant List by Core Faculty

Timothy R. Sterling M.D.
Professor of Medicine
Division of Infectious Diseases
Vanderbilt Tuberculosis Center

Predictors of Treatment Toxicity, Failure, and Relapse in HIV-related Tuberculosis NIH/NIAID
The aim of this project is to optimize the treatment of HIV-related tuberculosis in a large, genetically diverse cohort in Brazil. These results will lay the groundwork for drug dosing and regimens that improve outcomes and treatment effectiveness of HIV-related tuberculosis.

 

Regional Prospective Observational Research for TB (RePORT)-Brazil NIH/NIAID Supplement to Caribbean, Central and South America network for HIV epidemiology (CCASAnet)
With joint funding from the NIH and the Brazilian Ministry of Health, this is a prospective, multi-center cohort of TB cases and close contacts in Rio de Janeiro, Salvador, and Manaus, Brazil. There is a biorepository of M. tuberculosis isolates, cells, DNA, and RNA. Studies will be performed of host and pathogen determinants of TB treatment response, recurrence, acquiring M. tuberculosis infection, and progressing to TB disease.
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Regional Prospective Observational Research (RePORT) South Africa
U.S. Civilian Research and Development Foundation
In partnership with the Africa Health Research Institute in Durban, South Africa, we are assessing novel biomarkers of tuberculosis treatment response.
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TB Trials Consortium CDC Universidad Cayetano Heredia, Lima, Peru
This consortium conducts programmatically relevant studies of tuberculosis treatment and prevention.