Crabtree Ramírez B, Caro Vega Y, Shepherd BE, Le C, Turner M, Frola C, Grinsztejn B, Cortes C, Padgett D, Sterling TR, McGowan CC, Person A. Outcomes of HIV-positive patients with cryptococcal meningitis in the Americas. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2017 Oct;63(63). 57-63. PMID: 28807740 [PubMed]
Cryptococcal meningitis (CM) is associated with substantial mortality in HIV-infected patients. Optimal timing of antiretroviral therapy (ART) in persons with CM represents a clinical challenge, and the burden of CM in Latin America has not been well described. Studies suggest that early ART initiation is associated with higher mortality, but data from the Americas are scarce.