Eilertson B, Maruri F, Blackman A, Guo Y, Herrera M, Van der Heijden Y, Shyr Y, Sterling TR. A novel resistance mutation in eccC5 of the ESX-5 secretion system confers ofloxacin resistance in Mycobacterium tuberculosis. The Journal of antimicrobial chemotherapy. 2016 Sep;71(71). 2419-27. PMID: 27261264 [PubMed] PMCID: PMC4992850
Fluoroquinolone resistance in Mycobacterium tuberculosis is often conferred by DNA gyrase mutations. However, a substantial proportion of fluoroquinolone-resistant M. tuberculosis isolates do not have such mutations.