Huaman MA, Henson D, Rondan PL, Ticona E, Miranda G, Kryscio RJ, Mugruza R, Aranda E, Ticona C, Abarca S, Heredia P, Aguirre A, Sterling TR, Garvy BA, Fichtenbaum CJ. Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru. PloS one. 13(13). e0202191. PMID: 30212453 [PubMed] PMCID: PMC6136705
We previously reported increased unstimulated blood levels of interferon-gamma in persons with latent tuberculosis infection (LTBI) in the United States, suggesting enhanced immune activation in LTBI. To investigate this further in a TB-endemic setting, we assessed interferon-gamma levels in persons with and without LTBI in Peru.