Electronic Medical Records (EMR) systems show promise for facilitating health care improvement in quality patient care, patient safety and cost reduction. Nevertheless, their adoption requires careful planning and execution for successful implementation and optimal benefits. The main objective of this review was to identify, analyse and categorize facilitators and barriers to the implementation of EMRs in resource constrained settings in order to gain insight for successful EMR implementation. A literature review on papers from 2007 to 2017 concerning facilitators and barriers to EMRs implementation was conducted. The study included 18 articles that met selection criteria. Four categories of facilitators and barriers including a total of 28 sub-categories were identified from content analysis. These are technical, human, processes and organizational. EMR implementers should pay attention to these issues and adopt a change management strategy for sustainable EMR use in resource-constrained settings.